Publikasi Scopus FKUI 2021 per tanggal 31 Oktober 2021 (739 artikel)

Estiasari R., Diwyacitta A., Sidik M., Rida Ariarini N.N., Sitorus F., Marwadhani S.S., Maharani K., Imran D., Arpandy R.A., Pangeran D., Hakim M.
55240204000;57225009324;56252760000;57225009527;57208331594;57203760168;57189235094;57203976849;49361070700;57203764449;57216861859;
Evaluation of Retinal Structure and Optic Nerve Function Changes in Multiple Sclerosis: Longitudinal Study with 1-Year Follow-Up
2021
Neurology Research International
2021
5573839
Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Ophtalmology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia
Estiasari, R., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Diwyacitta, A., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Sidik, M., Department of Ophtalmology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Rida Ariarini, N.N., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Sitorus, F., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Marwadhani, S.S., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Maharani, K., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Imran, D., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Arpandy, R.A., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Pangeran, D., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Hakim, M., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia
Background. Multiple sclerosis (MS) is an autoimmune disease characterized by inflammation and demyelination of the central nervous system which often involves the optic nerve even though only 20% of the patients experience optic neuritis (ON). Objective. This study aims to compare the retinal structure and optic nerve function between patients with MS and healthy controls (HCs), evaluate optic nerve alterations in MS over 1-year follow-up, and analyze its correlations with disease duration, number of relapses, degree of disability, and different subtypes. Methods. This is a prospective cohort study involving 58 eyes of MS patients. Optic nerve function was evaluated with best-corrected visual acuity (BCVA), contrast sensitivity, and P100 latency, while the retinal structure was evaluated from the GCIPL and RNFL thickness measured with optical coherence tomography (OCT) and fundus photography. Results. The MS group had lower BCVA (p=0.001), contrast sensitivity (p<0.001), mean GCIPL thickness (p<0.001), and mean RNFL thickness (p<0.001) than HC. At 6 and 12 months of observations, GCIPL and RNFL (nasal quadrant) of MS patients decreased significantly (p=0.007 and p=0.004, respectively). Disease duration and the number of relapses correlated with delayed P100 latency (r = -0.61, p<0.001 and r = -0.46, p=0.02). GCIPL and RNFL in the SPMS subtype were thinner than in RRMS. Conclusions. The retinal structure and optic nerve function of MS patients are worse than those of normal individuals. GCIPL and RNFL thinning occurs at 6 and 12 months but do not correlate with disease duration, the number of relapses, and degree of disability. ? 2021 Riwanti Estiasari et al.
Hindawi Limited
20901852
Article
Q3
365
12980