Riset dan Pengabdian Masyarakat
Do Research Sosial Service and Innovation
Publikasi Scopus FKUI 2021 per tanggal 31 Oktober 2021 (739 artikel)
Publikasi Scopus FKUI 2021 per tanggal 31 Oktober 2021 (739 artikel)
Xanthine oxidase inhibition in sars-cov-2 infection: The mechanism and potency of allopurinol and febuxostat in covid-19 management
2021
Medical Journal of Indonesia
30
1
75
80
2
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104949199&doi=10.13181%2fmji.rev.204641&partnerID=40&md5=689e842e1dfa9cde24da9c6f8f7bbee1
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia; Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunksumo Hospital, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas IPB, Bogor, Indonesia; Tropical Biopharmaca Research Center, Universitas IPB, Bogor, Indonesia
The number of coronavirus disease 2019 (COVID-19) infection cases has been increasing globally, including in Indonesia. Definitive therapy for COVID-19 has not yet been found; hence, repurposed drugs for COVID-19 have been considered and have been practiced by several researchers in the world. This literature review investigates the action of xanthine oxidase as a component of the biomolecular pathway against severe acute respiratory syndrome-related coronavirus-2, the cause of COVID-19, and describes the mechanism and potential of uric acid drugs (allopurinol and febuxostat) as prophylaxis and curative therapy for COVID-19. ? 2020 Authors.
allopurinol; C reactive protein; febuxostat; free radical; gamma interferon; interleukin 2; interleukin 6; reactive oxygen metabolite; uric acid; xanthine oxidase; animal model; coronavirus disease 2019; cytokine production; cytokine storm; drug potency; epithelium; influenza; mouse; neutrophil; nonhuman; oxidative stress; pathogenesis; poultry; respiratory virus; Review; Severe acute respiratory syndrome coronavirus 2; virus infection
Faculty of Medicine, Universitas Indonesia
8531773
Review
Q4
164
21905