Publikasi Scopus FKUI 2021 per tanggal 31 Oktober 2021 (739 artikel)

Autologous platelet-rich plasma (PRP) was reported as having potent antimicrobial properties. However, the literature showed conflicting results. Therefore, we aim to investigate the effectiveness of topical autologous PRP as prophylaxis to prevent wound infection. We searched major electronic databases such as MEDLINE, EMBASE, CENTRAL, and Web of Science to identify RCT studies regarding this topic. The selection of included studies followed the PRISMA guidelines. We included ten RCTs comprising 1257 participants. In general, PRP showed no effect in reducing the risk of wound infection (RR: 0.84; 95% CI: 0.66?1.06; p=0.14). However, subgroup analysis based on wound characteristic showed that PRP significantly reduced wound infection risks in acute wounds (RR: 0.76; 95% CI: 0.58?0.99; p=0.04). Meanwhile, activation of PRP had no effect in reducing wound infection risks (p=0.77). In conclusion, we suggest routine autologous topical PRP application in acute wound care due to PRP antimicrobial properties and regenerative potential. ? 2021 UPM Press. All rights reserved.