Publikasi Scopus FKUI 2021 per tanggal 31 Oktober 2021 (739 artikel)

Authors_(Last_Name)

Nurhayati R.W., Cahyo R.D., Pratama G., Anggraini D., Mubarok W., Kobayashi M., Antarianto R.D.

Author S Id

55748436600;57212460506;57195959221;57221606578;57208440063;20835016200;57190862806;

Title

Alginate-chitosan microencapsulated cells for improving cd34+ progenitor maintenance and expansion

Year

2021

Source Title

Applied Sciences (Switzerland)

Volume

Issue

Art No

7887

Page Start

Page End

Page Count

Cited By

Link

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114106674&doi=10.3390%2fapp11177887&partnerID=40&md5=8aa18a5d52c69e6eb72dcb38252f4489

Affiliations

Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Prof. Soemantri Brojonegoro, Kampus UI, Depok, 16424, Indonesia; Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia; Department of Biotechnology, Faculty of Engineering, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan; Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia?Dr. Cipto Mangunkusumo General Hospital, Jl. Diponegoro No. 71, Central Jakarta, 10430, Indonesia; Integrated Service Unit of Stem Cell Medical Technology (IPT TK Sel Punca), Dr. Cipto Mangunkusumo General Hospital (RSCM), Jl. Diponegoro No. 71, Salemba, Central Jakarta, 10430, Indonesia; Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan; Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka, 560-8531, Japan; Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia

Authors With Affiliations

Nurhayati, R.W., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Prof. Soemantri Brojonegoro, Kampus UI, Depok, 16424, Indonesia, Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia; Cahyo, R.D., Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia, Department of Biotechnology, Faculty of Engineering, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan; Pratama, G., Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia?Dr. Cipto Mangunkusumo General Hospital, Jl. Diponegoro No. 71, Central Jakarta, 10430, Indonesia, Integrated Service Unit of Stem Cell Medical Technology (IPT TK Sel Punca), Dr. Cipto Mangunkusumo General Hospital (RSCM), Jl. Diponegoro No. 71, Salemba, Central Jakarta, 10430, Indonesia; Anggraini, D., Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia, Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan; Mubarok, W., Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia, Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka, 560-8531, Japan; Kobayashi, M., Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan; Antarianto, R.D., Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia, Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia

Abstract

Protocols for isolation, characterization, and transplantation of hematopoietic stem cells (HSCs) have been well established. However, difficulty in finding human leucocyte antigens (HLA)-matched donors and scarcity of HSCs are still the major obstacles of allogeneic transplanta-tion. In this study, we developed a double-layered microcapsule to deliver paracrine factors from non-matched or low-matched HSCs to other cells. The umbilical cord blood-derived hematopoietic progenitor cells, identified as CD34+ cells, were entrapped in alginate polymer and further protected by chitosan coating. The microcapsules showed no toxicity for surrounding CD34+ cells. When CD34+ cells-loaded microcapsules were co-cultured with bare CD34+ cells that have been collected from unrelated donors, the microcapsules affected surrounding cells and increased the percentage of CD34+ cell population. This study is the first to report the potency of alginate-chitosan microcap-sules containing non-HLA-matched cells for improving proliferation and progenitor maintenance of CD34+ cells. ? 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Author Keywords

Alginate; CD34; Chitosan; Hematopoietic; Megakaryocyte; Microencapsulation; Progenitor; Proliferation; Stem cells

Index Keywords

Publisher

MDPI

Issn

20763417

Isbn

Pubmed Id

Document Type

Article

Sjr Best Quartile

Sjr

435

Sjr Rank

11324