Publikasi Scopus Covid-19 Per 14 Agustus 2024 (559 artikel)

D-dimer level on admission is a promising biomarker to predict mortality in patients with COVID-19. In this study, we reviewed the association between on-admission D-dimer levels and all-cause mortality risk in COVID-19 patients. Peer-reviewed studies and preprints reporting categorized D-dimer levels on admission and all-cause mortality until 24 May 2020 were searched for using the following keywords: “COVID-19”, “D-dimer”, and “Mortality”. A meta-analysis was performed to determine the pooled risk ratio (RR) for all-cause mortality. 2911 COVID-19 patients from nine studies were included in this meta-analysis. Regardless of the different D-dimer cut-off values used, the pooled RR for all-cause mortality in patients with elevated vs normal on-admission D-dimer level was 4.77 (95%CI 3.02-7.54). Sensitivity analysis did not significantly affect the overall mortality risk. Analysis restricted to studies with 0.5 µg/mL as the cut-off value resulted in a pooled RR for mortality of 4.60 (95%CI 2.72-7.79). Subgroup analysis showed that the pooled all-cause mortality risk was higher in Chinese vs non-Chinese studies (RR 5.87; 95%CI: 2.67-12.89 and RR 3.35; 95%CI: 1.66-6.73; p=0.29). On-admission D-dimer levels showed a promising prognostic role for predicting all-cause mortality in COVID-19 patients, elevated D-dimer levels were associated with increased risk of mortality. © 2020 Society of Exploration Geophysicists. All rights reserved.