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Publikasi Scopus Covid-19 Per 14 Agustus 2024 (559 artikel)
Publikasi Scopus Covid-19 Per 14 Agustus 2024 (559 artikel)
Setiati, Siti (14325991900); Harimurti, Kuntjoro (23473513200); Safitri, Eka D. (57195934356); Ranakusuma, Respati W. (57189729404); Saldi, Siti Rizny F. (55201904000); Azwar, Muhammad K. (57202798959); Marsigit, Jessica (57218912589); Pitoyo, Yupitri (57189729239); Widyaningsih (57216351473)
Risk Factors and Laboratory Test Results Associated with Severe Illness and Mortality in COVID-19 Patients: A systematic review
2020
Acta Medica Indonesiana
52
3
227
245
18
19
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092620928&partnerID=40&md5=ed3a4ab803c3515162a1164c36f94c59
Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Background: we aimed to systematically review all relevant studies related to the risk factors and laboratory test results associated with severe illness and mortality in COVID-19 patients. Methods: we utilised PubMed, Scopus, ProQuest, Wiley Online Library, ScienceDirect and MedRxiv to search for studies, with additional hand-searched journals. We included systematic reviews/meta-analyses, cohort and case control studies of suspected and/or confirmed COVID-19 cases with severe illness and/or mortality as outcomes. We included laboratory test results and risk factors. We assessed risk of bias using ROBIS-I and Newcastle-Ottawa Scale assessment tool. Type of study, risk of bias, and precision of results determined evidence sufficiency. Results: of 26 records included, sufficient evidence suggested the association between age >60 years, hypertension, coronary heart disease, DM, serum LDH 250-500 U/L, LDH >500 U/L, and lymphopenia (lymphocyte count ≤1.0 x 109 /L) and severe illness of COVID-19. CD3+CD8+ cell count ≤ 75 cell/μl, D-dimer > 1 mg/L, AKI stage 2 and 3, proteinuria ≥1+, hematuria ≥1+, and peak serum creatinine > 13.26 μmol/L are associated with mortality. Conclusion: age >60 years, hypertension, DM, and coronary heart disease are the risk factors for severe illness of COVID-19. Laboratory test results associated with severe illness are serum LDH 250-500 U/L, LDH >500 U/L, and lymphopenia, whereas test results associated with mortality are CD3+CD8+ cell count ≤ 75 cell/μl, AKI stage 2 and 3, proteinuria ≥1+, hematuria ≥1+, D-dimer > 1 mg/L, peak serum creatinine > 13.26 μmol/L. © 2020, Indonesian Society of Internal Medicine. All rights reserved.
Betacoronavirus; Clinical Laboratory Techniques; Coronavirus Infections; Critical Illness; Global Health; Humans; Pandemics; Pneumonia, Viral; Risk Factors; Survival Rate; Betacoronavirus; Coronavirus infection; critical illness; global health; human; laboratory technique; meta analysis; pandemic; procedures; risk factor; survival rate; virus pneumonia
Dean and Research Manager of Faculty of Medicine Universitas Indonesia; Direktorat Riset and Pengembangan, Universitas Indonesia, DRPM UI
Funding text 1: We thank the Dean and Research Manager of Faculty of Medicine Universitas Indonesia, as well as the directors of Cipto Mangunkusumo Hospital.; Funding text 2: We declare that this study was supported by grant from the Directorate of Research and Development, Universitas Indonesia on Internationally Indexed Publication (PUTI)
Indonesian Society of Internal Medicine
01259326
33020334
Article
Q3