Publikasi Scopus Covid-19 Per 14 Agustus 2024 (559 artikel)

Aditianingsih D.; Soenarto R.F.; Puiantana A.M.; Pranata R.; Lim M.A.; Raharja P.A.R.; Birowo P.; Meyer M.
Aditianingsih, Dita (56312263600); Soenarto, Ratna Farida (57205249108); Puiantana, Artheta Mutiara (59004066300); Pranata, Raymond (57201973901); Lim, Michael Anthonius (57216039756); Raharja, Putu Angga Risky (57201013616); Birowo, Ponco (6504153311); Meyer, Markus (57217373886)
56312263600; 57205249108; 59004066300; 57201973901; 57216039756; 57201013616; 6504153311; 57217373886
Dose response relationship between D-dimer level and mortality in critically ill COVID-19 patients: a retrospective observational study
2022
F1000Research
11
269
1
Division of Critical Care, Universitas Indonesia Hospita, Depok, Jawa Barat, Indonesia; Department of Anesthesia and Intensive Care, Dr. Cipto Mangunkusumo Hospital - Universitas Indonesia Hospital, DKI Jakarta, Jakarta, Indonesia; Faculty of Medicine, Pelita Harapan University, Tangerang, Banten, Indonesia; Department of Urology, Dr. Cipto Mangunkusumo Hospital - Universitas Indonesia Hospital, DKI Jakarta, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Jakarta, Indonesia
Aditianingsih D., Division of Critical Care, Universitas Indonesia Hospita, Depok, Jawa Barat, Indonesia, Department of Anesthesia and Intensive Care, Dr. Cipto Mangunkusumo Hospital - Universitas Indonesia Hospital, DKI Jakarta, Jakarta, Indonesia; Soenarto R.F., Department of Anesthesia and Intensive Care, Dr. Cipto Mangunkusumo Hospital - Universitas Indonesia Hospital, DKI Jakarta, Jakarta, Indonesia; Puiantana A.M., Department of Anesthesia and Intensive Care, Dr. Cipto Mangunkusumo Hospital - Universitas Indonesia Hospital, DKI Jakarta, Jakarta, Indonesia; Pranata R., Faculty of Medicine, Pelita Harapan University, Tangerang, Banten, Indonesia; Lim M.A., Faculty of Medicine, Pelita Harapan University, Tangerang, Banten, Indonesia; Raharja P.A.R., Department of Urology, Dr. Cipto Mangunkusumo Hospital - Universitas Indonesia Hospital, DKI Jakarta, Jakarta, Indonesia; Birowo P., Department of Urology, Dr. Cipto Mangunkusumo Hospital - Universitas Indonesia Hospital, DKI Jakarta, Jakarta, Indonesia; Meyer M., Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Jakarta, Indonesia
BACKGROUND: Coronavirus disease 2019 (COVID-19) is a global pandemic. Coagulopathy is one of the most common complications characterized by increased D-dimer level. We aimed to investigate the dose-response relationship between elevated D-dimer level and mortality in critically ill COVID-19 patients. METHODS: This was a retrospective observational study in 259 critically ill COVID-19 patients requiring intensive care unit admission between March and December 2020. We compared the mortality rate between patients with and without elevated D-dimer. Receiver operating characteristic (ROC) curve analysis, Fagan's nomogram, and dose-response relationship were performed to determine the association between D-dimer level and mortality. RESULTS: Overall mortality rate was 40.9% (106 patients). Median D-dimer level was higher in non-survivor group (10,170 ng/mL vs 4,050 ng/mL, p=0.028). The association remained significant after multivariate logistic regression analysis (p=0.046). The optimal cut-off for D-dimer level to predict mortality from ROC curve analysis was 9,020 ng/mL (OR (odds ratio) 3.73 [95% CI (confidence interval) 1.91 - 7.28], p<0.001). D-dimer level >9,020 ng/mL confers 67% posterior probability of mortality and D-dimer level <9,020 ng/mL had 35% probability of mortality. CONCLUSIONS: There was a non-linear dose-response relationship between D-dimer level and mortality with P nonlinearity of 0.004. D-dimer level was associated with mortality in critically ill COVID-19 patients in the non-linear dose-response relationship. Copyright: © 2023 Aditianingsih D et al.
COVID-19; critically ill; D-dimer; dose-response relationship; mortality
Adult; Aged; COVID-19; Critical Illness; Female; Fibrin Fibrinogen Degradation Products; Humans; Intensive Care Units; Male; Middle Aged; Retrospective Studies; ROC Curve; SARS-CoV-2; fibrin degradation product; fibrin fragment D; adult; aged; blood; coronavirus disease 2019; critical illness; female; human; intensive care unit; male; metabolism; middle aged; mortality; receiver operating characteristic; retrospective study; Severe acute respiratory syndrome coronavirus 2
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