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Publikasi Scopus Covid-19 Per 14 Agustus 2024 (559 artikel)
Publikasi Scopus Covid-19 Per 14 Agustus 2024 (559 artikel)
Rachman, Andhika (15056701600); Iriani, Anggraini (57192888893); Sukrisman, Lugyanti (8661764000); Rajabto, Wulyo (36519576100); Mulansari, Nadia Ayu (36519326000); Lubis, Anna Mira (56702707800); Cahyanur, Rahmat (37066991400); Prasetyawati, Findy (57195934843); Priantono, Dimas (57219443427); Rumondor, Bayu Bijaksana (57210794551); Betsy, Rachelle (58035832700); Juanputra, Samuel (58035300800)
A comparative study of the COVID-19 vaccine efficacy among cancer patients: mRNA versus non-mRNA
2023
PLoS ONE
18
3 March
e0281907
2
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85149427457&doi=10.1371%2fjournal.pone.0281907&partnerID=40&md5=495448357a275caa5168ebceab50f141
Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pathology, Yarsi University, Jakarta, Indonesia; Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia
Background Cancer patients have an increased risk of a severe COVID-19 infection with higher mortality rate. This study aimed to analyze the levels of anti-SARS-CoV-2 S-RBD IgG and NAB among cancer patients who were vaccinated with COVID-19 vaccines, either with BNT162b2, mRNA-1273, AZD1222/ChAdOx1nCoV-19, or Coronavac/BBIBP-CorV vaccines. Method A cross-sectional study was conducted among subjects with either solid or hematological cancers who had received two doses of either mRNA or non-mRNA vaccines within 6 months. The levels of anti-SARS-CoV-2 S-RBD IgG and NAb were analyzed using the Mindray Immunoassay Analyzer CL-900i. Statistical analysis was conducted using mean comparison and regression analysis. Result The mRNA-1273 vaccine had the highest median levels of S-RBD IgG and NAb, followed by BNT162b, ChAdOx1nCoV-19, and BBIBP-CorV/Coronavac. The levels of S-RBD IgG and NAb in subjects vaccinated with mRNA vaccines were significantly higher than those of non-mRNA vaccines when grouped based on their characteristics, including age, type of cancer, chemotherapy regimen, and comorbidity (p<0.05). Furthermore, the S-RBD IgG and NAb levels between the subjects vaccinated with non-mRNA vaccines and the subjects vaccinated with mRNA vaccines were significantly different (p<0.05). However, there was no significant difference between the same types of vaccines. This study demonstrated a very strong correlation between the level of S-RBD IgG and the level of NAb (R = 0.962; p<0.001). The level of anti-SARS-CoV-2 S-RBD IgG was consistently higher compared to the level of NAb. Conclusions Generally, mRNA vaccines produced significantly higher anti-SARS-CoV-2 S-RBD IgG and NAb levels than non-mRNA vaccines in cancer subjects. Copyright: © 2023 Rachman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
2019-nCoV Vaccine mRNA-1273; BNT162 Vaccine; ChAdOx1 nCoV-19; COVID-19; COVID-19 Vaccines; Cross-Sectional Studies; Humans; Immunoglobulin G; Neoplasms; RNA, Messenger; SARS-CoV-2; coronavac; elasomeran; immunoglobulin G; neutralizing antibody; SARS-CoV-2 vaccine; tozinameran; vaxzevria; BIBP COVID-19 vaccine; immunoglobulin G; messenger RNA; adult; age; Article; cancer chemotherapy; cancer patient; comorbidity; comparative effectiveness; cross-sectional study; female; human; major clinical study; male; middle aged; multicenter study; risk factor; vaccination; neoplasm
Ethics Committee of The Faculty of Medicine, Universitas Indonesia, (F1/ETIK/PPM.00.02/2021)
This research was funded by Dr. Cipto Mangunkusumo National Central General Hospital’s grant program “Hibah Riset Operasional RSCM” (grant number: LB.01.02/2.6/0668/2021). Ethical approval for this study was granted by The Ethics Committee of The Faculty of Medicine, Universitas Indonesia (ethical approval number: KET–999/UN2.F1/ETIK/PPM.00.02/2021). the funders had no role in study design, data c
Public Library of Science
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