Publikasi Scopus 2023 per tanggal 31 Januari 2023 (41 artikel)

Han W.M., Avihingsanon A., Rajasuriar R., Tanuma J., Mundhe S., Lee M.-P., Choi J.Y., Pujari S., Chan Y.-J., Somia A., Zhang F., Kumarasamy N., Tek Ng O., Gani Y., Chaiwarith R., Pham T.N., Do C.D., Ditangco R., Kiertiburanakul S., Khol V., Ross J., Jiamsakul A., Ly P.S., Zhao H.X., Han N., Li P.C.K., Lam W., Chan Y.T., Ezhilarasi C., Joshi K., Gaikwad S., Chitalikar A., Sangle S., Mave V., Marbaniang I., Nimkar S., Merati T.P., Wirawan D.N., Yuliana F., Yunihastuti E., Widhani A., Maria S., Karjadi T.H., Oka S., Nishijima T., Na S., Kim J.M., Rudi N.B., Azwa I., Kamarulzaman A., Syed Omar S.F., Ponnampalavanar S., Pasayan M.K., Mationg M.L., Ku W.W., Wu P.C., Ke E., Lim P.L., Lee L.S., Liang D., Gatechompol S., Phanuphak P., Phadungphon C., Phuphuakrat A., Chumla L., Sanmeema N., Sirisanthana T., Praparattanapan J., Nuket K., Khusuwan S., Kantipong P., Kambua P., Nguyen K.V., Bui H.V., Nguyen D.T.H., Nguyen D.T., Ngo A.V., Nguyen L.T., Sohn A.H., Ross J.L., Petersen B., Law M.G., Jiamsakul A., Bijker R., Rupasinghe D.
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CD4/CD8 Ratio Recovery among People Living with HIV Starting with First-Line Integrase Strand Transfer Inhibitors: A Prospective Regional Cohort Analysis
2023
Journal of Acquired Immune Deficiency Syndromes
92
2
180
188
The Kirby Institute, UNSW SydneyNSW, Australia; HIV-NAT/Thai Red Cross AIDS Research Centre, Centre of Excellence in Tuberculosis, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia; National Center for Global Health and Medicine, Tokyo, Japan; BJ Government Medical College, Sassoon General Hospital, Pune, India; Queen Elizabeth Hospital, Hong Kong, Hong Kong; Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Institute of Infectious Diseases, Pune, India; Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine Udayana University, Sanglah Hospital, Bali, Indonesia; Beijing Ditan Hospital, Capital Medical University, Beijing, China; CART CRS, Voluntary Health Services, Chennai, India; Tan Tock Seng Hospital, National Centre for Infectious Diseases, Singapore, Singapore; Hospital Sungai Buloh, Sungai Buloh, Malaysia; Chiang Mai University, Research Institute for Health Sciences, Chiang Mai, Thailand; National Hospital for Tropical Diseases, Hanoi, Viet Nam; Bach Mai Hospital, Hanoi, Viet Nam; Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; National Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia; TREAT Asia, AmfAR-the Foundation for AIDS Research, Bangkok, Thailand; Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHSInfectious Diseases Medical Centre, VHS, Chennai, India; Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; University Malaya Medical Centre, Kuala Lumpur, Malaysia; Tan Tock Seng Hospital, Singapore, Singapore; HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Research Institute for Health Sciences, Chiang Mai, Thailand; Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand
Han, W.M., The Kirby Institute, UNSW SydneyNSW, Australia, HIV-NAT/Thai Red Cross AIDS Research Centre, Centre of Excellence in Tuberculosis, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Avihingsanon, A., HIV-NAT/Thai Red Cross AIDS Research Centre, Centre of Excellence in Tuberculosis, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Rajasuriar, R., Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Tanuma, J., National Center for Global Health and Medicine, Tokyo, Japan; Mundhe, S., BJ Government Medical College, Sassoon General Hospital, Pune, India; Lee, M.-P., Queen Elizabeth Hospital, Hong Kong, Hong Kong; Choi, J.Y., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Pujari, S., Institute of Infectious Diseases, Pune, India; Chan, Y.-J., Taipei Veterans General Hospital, Taipei, Taiwan; Somia, A., Faculty of Medicine Udayana University, Sanglah Hospital, Bali, Indonesia; Zhang, F., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Kumarasamy, N., CART CRS, Voluntary Health Services, Chennai, India; Tek Ng, O., Tan Tock Seng Hospital, National Centre for Infectious Diseases, Singapore, Singapore; Gani, Y., Hospital Sungai Buloh, Sungai Buloh, Malaysia; Chaiwarith, R., Chiang Mai University, Research Institute for Health Sciences, Chiang Mai, Thailand; Pham, T.N., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Do, C.D., Bach Mai Hospital, Hanoi, Viet Nam; Ditangco, R., Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Kiertiburanakul, S., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Khol, V., National Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia; Ross, J., TREAT Asia, AmfAR-the Foundation for AIDS Research, Bangkok, Thailand; Jiamsakul, A., The Kirby Institute, UNSW SydneyNSW, Australia; Ly, P.S., National Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia; Zhao, H.X., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Han, N., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Li, P.C.K., Queen Elizabeth Hospital, Hong Kong, Hong Kong; Lam, W., Queen Elizabeth Hospital, Hong Kong, Hong Kong; Chan, Y.T., Queen Elizabeth Hospital, Hong Kong, Hong Kong; Ezhilarasi, C., Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHSInfectious Diseases Medical Centre, VHS, Chennai, India; Joshi, K., Institute of Infectious Diseases, Pune, India; Gaikwad, S., Institute of Infectious Diseases, Pune, India; Chitalikar, A., Institute of Infectious Diseases, Pune, India; Sangle, S., BJ Government Medical College, Sassoon General Hospital, Pune, India; Mave, V., BJ Government Medical College, Sassoon General Hospital, Pune, India; Marbaniang, I., BJ Government Medical College, Sassoon General Hospital, Pune, India; Nimkar, S., BJ Government Medical College, Sassoon General Hospital, Pune, India; Merati, T.P., Faculty of Medicine Udayana University, Sanglah Hospital, Bali, Indonesia; Wirawan, D.N., Faculty of Medicine Udayana University, Sanglah Hospital, Bali, Indonesia; Yuliana, F., Faculty of Medicine Udayana University, Sanglah Hospital, Bali, Indonesia; Yunihastuti, E., Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Widhani, A., Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Maria, S., Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Karjadi, T.H., Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Oka, S., National Center for Global Health and Medicine, Tokyo, Japan; Nishijima, T., National Center for Global Health and Medicine, Tokyo, Japan; Na, S., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Kim, J.M., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Rudi, N.B., Hospital Sungai Buloh, Sungai Buloh, Malaysia; Azwa, I., University Malaya Medical Centre, Kuala Lumpur, Malaysia; Kamarulzaman, A., University Malaya Medical Centre, Kuala Lumpur, Malaysia; Syed Omar, S.F., University Malaya Medical Centre, Kuala Lumpur, Malaysia; Ponnampalavanar, S., University Malaya Medical Centre, Kuala Lumpur, Malaysia; Pasayan, M.K., Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Mationg, M.L., Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Ku, W.W., Taipei Veterans General Hospital, Taipei, Taiwan; Wu, P.C., Taipei Veterans General Hospital, Taipei, Taiwan; Ke, E., Taipei Veterans General Hospital, Taipei, Taiwan; Lim, P.L., Tan Tock Seng Hospital, Singapore, Singapore; Lee, L.S., Tan Tock Seng Hospital, Singapore, Singapore; Liang, D., Tan Tock Seng Hospital, Singapore, Singapore; Gatechompol, S., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Phanuphak, P., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Phadungphon, C., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Phuphuakrat, A., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Chumla, L., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Sanmeema, N., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Sirisanthana, T., Research Institute for Health Sciences, Chiang Mai, Thailand; Praparattanapan, J., Research Institute for Health Sciences, Chiang Mai, Thailand; Nuket, K., Research Institute for Health Sciences, Chiang Mai, Thailand; Khusuwan, S., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Kantipong, P., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Kambua, P., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Nguyen, K.V., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Bui, H.V., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Nguyen, D.T.H., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Nguyen, D.T., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Ngo, A.V., Bach Mai Hospital, Hanoi, Viet Nam; Nguyen, L.T., Bach Mai Hospital, Hanoi, Viet Nam; Sohn, A.H., TREAT Asia, AmfAR-the Foundation for AIDS Research, Bangkok, Thailand; Ross, J.L., TREAT Asia, AmfAR-the Foundation for AIDS Research, Bangkok, Thailand; Petersen, B., TREAT Asia, AmfAR-the Foundation for AIDS Research, Bangkok, Thailand; Law, M.G., The Kirby Institute, UNSW SydneyNSW, Australia; Jiamsakul, A., The Kirby Institute, UNSW SydneyNSW, Australia; Bijker, R., The Kirby Institute, UNSW SydneyNSW, Australia; Rupasinghe, D., The Kirby Institute, UNSW SydneyNSW, Australia
Background:We evaluated trends in CD4/CD8 ratio among people living with HIV (PLWH) starting antiretroviral therapy (ART) with first-line integrase strand transfer inhibitors (INSTI) compared with non-INSTI-based ART, and the incidence of CD4/CD8 ratio normalization.Methods:All PLWH enrolled in adult HIV cohorts of IeDEA Asia-Pacific who started with triple-ART with at least 1 CD4, CD8 (3-month window), and HIV-1 RNA measurement post-ART were included. CD4/CD8 ratio normalization was defined as a ratio ≥1. Longitudinal changes in CD4/CD8 ratio were analyzed by linear mixed model, the incidence of the normalization by Cox regression, and the differences in ratio recovery by group-based trajectory modeling.Results:A total of 5529 PLWH were included; 80% male, median age 35 years (interquartile range [IQR], 29-43). First-line regimens were comprised of 65% NNRTI, 19% PI, and 16% INSTI. The baseline CD4/CD8 ratio was 0.19 (IQR, 0.09-0.33). PLWH starting with NNRTI-(P = 0.005) or PI-based ART (P = 0.030) had lower CD4/CD8 recovery over 5 years compared with INSTI. During 24,304 person-years of follow-up, 32% had CD4/CD8 ratio normalization. After adjusting for age, sex, baseline CD4, HIV-1 RNA, HCV, and year of ART initiation, PLWH started with INSTI had higher odds of achieving CD4/CD8 ratio normalization than NNRTI-(P < 0.001) or PI-based ART (P = 0.015). In group-based trajectory modeling analysis, INSTI was associated with greater odds of being in the higher ratio trajectory.Conclusions:INSTI use was associated with higher rates of CD4/CD8 ratio recovery and normalization in our cohort. These results emphasize the relative benefits of INSTI-based ART for immune restoration. © 2023 Lippincott Williams and Wilkins. All rights reserved.
antiretroviral treatment; Asia-Pacific; CD4/CD8 ratio; immune dysfunction; INSTI
integrase; integrase inhibitor; RNA; adult; CD4 CD8 ratio; CD8+ T lymphocyte; cohort analysis; female; human; Human immunodeficiency virus infection; male; prospective study; Adult; CD4-CD8 Ratio; CD8-Positive T-Lymphocytes; Cohort Studies; Female; HIV Infections; HIV Integrase Inhibitors; Humans; Integrases; Male; Prospective Studies; RNA
U01AI069907; National Institutes of Health, NIH; National Institute of Mental Health, NIMH; National Institute on Drug Abuse, NIDA; National Institute on Alcohol Abuse and Alcoholism, NIAAA; National Heart, Lung, and Blood Institute, NHLBI; National Cancer Institute, NCI; National Institute of Allergy and Infectious Diseases, NIAID; National Institute of Diabetes and Digestive and Kidney Diseases, NIDDK; Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD; Depa
Supported by the US National Institutes of Health's National Institute of Allergy and Infectious Diseases, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Cancer Institute, the National Institute of Mental Health, the National Institute on Drug Abuse, the National Heart, Lung, and Blood Institute, the National Institute on Alcohol Abuse and Alcohol
Wolters Kluwer Health
15254135
36625858
Article
Q1
1469
2172