Publikasi Scopus 2024 per tanggal 29 Februari 2024 (130 artikel)

Margiana R.
Margiana, Ria (56685900600)
56685900600
Mesenchymal stem cell-derived exosomes in preeclampsia: A next-generation therapeutic tool
2024
Cell Biochemistry and Function
42
1
e3908
0
Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Andrology Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Margiana R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Andrology Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Preeclampsia (PE) is a major gestational disorder that causes both long- and short-term damage to both the mother and the fetus. Endometrium decidualization and the formation of the placenta are orchestrated by mesenchymal stem cells (MSCs). MSCs obtained from patients with PE exhibit an elevated rate of aging and apoptosis, which impairs the interplay between MSCs and endothelium, trophoblast, and immune cells in the placenta, accelerating the onset of PE. Preclinical and clinical evidence imply that the MSC-based therapy approach for PE is prospective. Importantly, as a novel cell-free approach, MSC-derived exosomes can improve symptoms and maternal–fetal survival in PE models by raising cell metabolism, encouraging angiogenesis balance, and regulating immune responses. Even following allogeneic administration, the likelihood of immune rejection is very limited as a result of the small quantity of exosome membrane-bound proteins. Furthermore, because exosomes do not expand, developing tumors is not probable. As a result, MSC-derived exosomes show superiority over MSCs in terms of safety. For the first time, we outline the properties of MSC-exosomes and highlight their functions and potential as a new paradigm for PE therapy in this review. © 2024 John Wiley & Sons Ltd.
angiogenesis; inflammation; mesenchymal stem cells; preeclampsia; treatment
Aging; Exosomes; Female; Humans; Membrane Proteins; Mesenchymal Stem Cells; Pre-Eclampsia; Pregnancy; Prospective Studies; membrane protein; adaptive immunity; angiogenesis; antiinflammatory activity; cell contact; exosome; female; human; immunomodulation; innate immunity; maternal infection; mesenchymal stem cell; nonhuman; paracrine signaling; periodontal disease; placental ischemia; preeclampsia; Review; trophoblast; aging; preeclampsia; pregnancy; prospective study
John Wiley and Sons Ltd
02636484
38269498
Review
Q2
753
6473