Riset dan Pengabdian Masyarakat
Do Research Sosial Service and Innovation
Publikasi Scopus 2024 per tanggal 29 Februari 2024 (130 artikel)
Publikasi Scopus 2024 per tanggal 29 Februari 2024 (130 artikel)
Putera, Ikhwanuliman (56485949000); Ridwan, Asri Salima (57211447435); Dewi, Metta (57222664086); Cifuentes-González, Carlos (57222074348); Rojas-Carabali, William (57219659910); Sitompul, Ratna (8312163900); Edwar, Lukman (55695047800); Susiyanti, Made (19640377300); Aziza, Yulia (57214455776); Pavesio, Carlos (7003495942); Chee, Soon-Phaik (7005885793); Mahendradas, Padmamalini (16481136500); Biswas, Jyotirmay (7102648244); Kempen, John H. (57216598048); Gupta, Vishali (35452834800); de-la-Tor
Antiviral treatment for acute retinal necrosis: A systematic review and meta-analysis
2024
Survey of Ophthalmology
69
1
67
84
17
0
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85174461915&doi=10.1016%2fj.survophthal.2023.09.004&partnerID=40&md5=eaa555e40d9f97c7556909f9be54e84c
Department of Ophthalmology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Kirana Eye Hospital, Jakarta, Indonesia; Erasmus University Medical Center, Rotterdam, Netherlands; Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Institute of Translational Medicine (IMT), Universidad Del Rosario Escuela de Medicina y Ciencias de la Salud, Bogotá, Colombia; Department of Bioinformatics, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore; National Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital, London, United Kingdom; UCL-Institute of Ophthalmology, London, United Kingdom; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Singapore National Eye Centre, Singapore, Singapore; Department of Uvea, Narayana Nethralaya, Karnataka, Bangalore, India; Department of Uvea and Ocular Pathology, Sankara Nethralaya, Tamil Nadu, Chennai, India; Department of Ophthalmology, Massachusetts Eye and Ear/Harvard Medical School; and Schepens Eye Research Institute, Boston, MA, United States; Sight for Souls, Fort Myers, FL, United States; Addis Ababa University Department of Ophthalmology, Addis Ababa, Ethiopia; MyungSung Christian Medical Center (MCM) Eye Unit, MCM General Hospital, and MyungSung Medical School, Addis Ababa, Ethiopia; Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India; National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore; Duke NUS Medical School, Singapore, Singapore; Singapore Eye Research Institute, Singapore, Singapore
Acute retinal necrosis is a progressive intraocular inflammatory syndrome characterized by diffuse necrotizing retinitis that can lead to a poor visual outcome, mainly from retinal detachment. The antiviral treatment approach for acute retinal necrosis varies as there are no established guidelines. We summarize the outcomes of acute retinal necrosis with available antiviral treatments. Electronic searches were conducted in PubMed/MEDLINE, EMBASE, Scopus, and Google Scholar for interventional and observational studies. Meta-analysis was performed to evaluate the pooled proportion of the predefined selected outcomes. This study was registered in PROSPERO (CRD42022320987). Thirty-four studies with a total of 963 participants and 1,090 eyes were included in the final analysis. The estimated varicella-zoster virus and herpes simplex virus polymerase chain reaction-positive cases were 63% (95% CI: 55–71%) and 35% (95% CI: 28–42%), respectively. The 3 main antiviral treatment approaches identified were oral antivirals alone, intravenous antivirals alone, and a combination of systemic (oral or intravenous) and intravitreal antivirals. The overall pooled estimated proportions of visual acuity improvement, recurrence, and retinal detachment were 37% (95% CI: 27–47%), 14% (95% CI: 8–21%), and 43% (95% CI: 38–50%), respectively. Patients treated with systemic and intravitreal antivirals showed a trend towards better visual outcomes than those treated with systemic antivirals (oral or intravenous) alone, even though this analysis was not statistically significant (test for subgroup differences P = 0.83). © 2023 The Author(s)
Acyclovir; Antiviral Agents; Eye Infections, Viral; Humans; Retinal Detachment; Retinal Necrosis Syndrome, Acute; Retrospective Studies; aciclovir; antivirus agent; human; Kirisawa uveitis; meta analysis; retina detachment; retrospective study; viral eye infection
Ministry of Health, MOH, (MOH-CSAINV19nov-0003, MOH-CSAINV22jul-0004); National Medical Research Council, NMRC; Lembaga Pengelola Dana Pendidikan, LPDP, (0004535/MED/D/19/lpdp2021)
Funding text 1: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. IP is supported by Indonesia Endowment Fund for Education (Lembaga Pengelola Dana Pendidikan – LPDP, No: 0004535/MED/D/19/lpdp2021 ). The funding source had no involvement in the collection, analysis, interpretation, writing of the report, and the decision to
Elsevier Inc.
00396257
37774799
Review
Q1
1595
1933