Publikasi Scopus 2024 per tanggal 29 Februari 2024 (130 artikel)

Fedrizal F.F.; Wijaya I.P.; Abdullah M.; Yamin M.
Fedrizal, Fenandri Fadillah (57219280233); Wijaya, Ika Prasetya (57193731572); Abdullah, Murdani (7103393434); Yamin, Muhammad (23475706300)
57219280233; 57193731572; 7103393434; 23475706300
Elevated neutrophyl-to-lymphocyte ratioand smoking are associated with chronic total occlusion in patients with ST elevation myocardial infarction
2024
BMC Cardiovascular Disorders
24
1
12
0
Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Unit Epidemiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia
Fedrizal F.F., Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Wijaya I.P., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Abdullah M., Unit Epidemiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Yamin M., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia
Background: Atherosclerosis is a progressive disease characterized by the build-up of lipids and connective tissue in the large arteries. Some patients experience chronic total occlusion (CTO). Inflammation plays a key role in the development and complications of atherosclerosis. Neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation associated with the development of acute coronary syndrome (ACS). We aimed to assess the relationship between NLR and CTO in ACS patients with ST elevated myocardial infarction (STEMI) in Indonesia. Methods: This cross-sectional study was performed with secondary data obtained from patient medical records at Cipto Mangunkusumo National Central Hospital, Jakarta. Inclusion criteria were patients with ACS and STEMI who underwent coronary angiography in 2015–2018. Results: A total of 98 patients were enrolled in the analysis. Most subjects with CTO were male, elderly (> 60), smoking, had no history of diabetes mellitus (DM) or hypertension, no family history of coronary heart disease (CHD), but had a history of ACS and had never consumed statin or antiplatelet medications. Bivariate logistic regression analysis revealed that male gender (PR = 1.820; 95%CI 0.871–3.805; p = 0.025) and smoking (PR = 1.781; 95%CI 1.028–3.086; p = 0.004) were significantly correlated with CTO. Receiver operator characteristic (ROC) curve revealed that higher NLR (≥ 6.42) could predict a CTO diagnosis with positive predictive value (PPV) of 91%. Multivariate analysis revealed that NLR was correlated with an 11.2-fold increase in occurrence of CTO (95%CI 3.250-38.303; p < 0.001). Additionally, smoking was correlated with a 7-fold increase in CTO (95% CI 1.791–30.508; p = 0.006). Conclusion: NLR value of ≥ 6.42 is potentially useful as a marker of CTO in STEMI patients. In addition, smoking increases the risk of CTO in ACS/STEMI patients. © 2023, The Author(s).
Chronic total occlusion; Coronary angiography; Coronary artery Disease; Myocardial Infarction; Neutrophil-to-lymphocyte ratio
Acute Coronary Syndrome; Aged; Atherosclerosis; Chronic Disease; Coronary Occlusion; Cross-Sectional Studies; Female; Humans; Inflammation; Lymphocytes; Male; Percutaneous Coronary Intervention; Smoking; ST Elevation Myocardial Infarction; Treatment Outcome; antithrombocytic agent; hydroxymethylglutaryl coenzyme A reductase inhibitor; acute coronary syndrome; adult; age; aged; Article; bivariate analysis; cardiovascular risk; chronic total occlusion; controlled study; coronary angiography; cross-sectional study; diabetes mellitus; diagnostic test accuracy study; disease association; female; human; hypertension; Indonesia; ischemic heart disease; logistic regression analysis; major clinical study; male; medical record; multivariate analysis; neutrophil lymphocyte ratio; predictive value; re
BioMed Central Ltd
14712261
38172732
Article
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