Publikasi Scopus 2024 per tanggal 29 Februari 2024 (130 artikel)

Kim C.; Agarwal S.; Bychkov A.; Hang J.-F.; Harahap A.S.; Hirokawa M.; Kakudo K.; Keelawat S.; Liu C.-Y.; Liu Z.; Nguyen T.P.-X.; Rana C.; Vuong H.G.; Zhu Y.; Jung C.K.
Kim, Chankyung (58888083900); Agarwal, Shipra (58828660400); Bychkov, Andrey (58887941900); Hang, Jen-Fan (56670935200); Harahap, Agnes Stephanie (57218511857); Hirokawa, Mitsuyoshi (35473587300); Kakudo, Kennichi (57195026520); Keelawat, Somboon (6507652685); Liu, Chih-Yi (37061399000); Liu, Zhiyan (55910503200); Nguyen, Truong Phan-Xuan (57218306094); Rana, Chanchal (35604481200); Vuong, Huy Gia (57147436100); Zhu, Yun (57194783991); Jung, Chan Kwon (8653433900)
58888083900; 58828660400; 58887941900; 56670935200; 57218511857; 35473587300; 57195026520; 6507652685; 37061399000; 55910503200; 57218306094; 35604481200; 57147436100; 57194783991; 8653433900
Differentiating BRAF V600E- and RAS-like alterations in encapsulated follicular patterned tumors through histologic features: a validation study
2024
Virchows Archiv
Department of Anatomical Pathology, SA Pathology, Adelaide, SA, Australia; Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia; Department of Pathology, All India Institute of Medical Sciences, New Delhi, 110029, India; Department of Pathology, Kameda Medical Center, Kamogawa City, Chiba 296-8602, Japan; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Japan; Department of Pathology and Thyroid Disease Center, Izumi City General Hospital, Izumi, Japan; Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Division of Pathology, Sijhih Cathay General Hospital, New Taipei City, Taiwan; Department of Pathology, Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai, China; Department of Pathology, King George Medical University, Lucknow, India; Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, United States; Department of Pathology, Jiangsu Institute of Nuclear Medicine, Wuxi, China; Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, South Korea; College of Medicine, Cancer Research Institute, The Catholic University of Korea, Seoul, South Korea; Department of Pathology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, South Korea
Kim C., Department of Anatomical Pathology, SA Pathology, Adelaide, SA, Australia, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia; Agarwal S., Department of Pathology, All India Institute of Medical Sciences, New Delhi, 110029, India; Bychkov A., Department of Pathology, Kameda Medical Center, Kamogawa City, Chiba 296-8602, Japan; Hang J.-F., Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Harahap A.S., Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hirokawa M., Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Japan; Kakudo K., Department of Pathology and Thyroid Disease Center, Izumi City General Hospital, Izumi, Japan; Keelawat S., Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Liu C.-Y., Division of Pathology, Sijhih Cathay General Hospital, New Taipei City, Taiwan; Liu Z., Department of Pathology, Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai, China; Nguyen T.P.-X., Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Rana C., Department of Pathology, King George Medical University, Lucknow, India; Vuong H.G., Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, United States; Zhu Y., Department of Pathology, Jiangsu Institute of Nuclear Medicine, Wuxi, China; Jung C.K., Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, South Korea, College of Medicine, Cancer Research Institute, The Catholic University of Korea, Seoul, South Korea, Department of Pathology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, South Korea
Differentiating BRAF V600E- and RAS-altered encapsulated follicular-patterned thyroid tumors based on morphology remains challenging. This study aimed to validate an 8-score scale nuclear scoring system and investigate the importance of nuclear pseudoinclusions (NPIs) in aiding this differentiation. A cohort of 44 encapsulated follicular-patterned tumors with varying degrees of nuclear atypia and confirmed BRAF V600E or RAS alterations was studied. Nuclear parameters (area, diameter, and optical density) were analyzed using a deep learning model. Twelve pathologists from eight Asian countries visually assessed 22 cases after excluding the cases with any papillae. Eight nuclear features were applied, yielding a semi-quantitative score from 0 to 24. A threshold score of 14 was used to distinguish between RAS- and BRAF V600E-altered tumors. BRAF V600E-altered tumors typically demonstrated higher nuclear scores and notable morphometric alterations. Specifically, the nuclear area and diameter were significantly larger, and nuclear optical density was much lower compared to RAS-altered tumors. Observer accuracy varied, with two pathologists correctly identifying genotype of all cases. Observers were categorized into proficiency groups, with the highest group maintaining consistent accuracy across both evaluation methods. The lower group showed a significant improvement in accuracy upon utilizing the 8-score scale nuclear scoring system, with notably increased sensitivity and negative predictive value in BRAF V600E tumor detection. BRAF V600E-altered tumors had higher median total nuclear scores. Detailed reevaluation revealed NPIs in all BRAF V600E-altered cases, but in only 2 of 14 RAS-altered cases. These results could significantly assist pathologists, particularly those not specializing in thyroid pathology, in making a more accurate diagnosis. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.
BRAF; Encapsulated follicular-patterned tumors; Morphometric analysis; Nuclear features; Papillary thyroid carcinoma; RAS
Ministry of Trade, Industry and Energy, MOTIE; Ministry of Food and Drug Safety, MFDS, (RS-2023-00243633); Ministry of Science, ICT and Future Planning, MSIP; Ministry of Health and Welfare, MOHW
This research was supported by a grant (HI21C0940) from the Korean Health Technology R&D Project funded by the Ministry of Health and Welfare, Republic of Korea. This work was also supported by the Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of
Springer Science and Business Media Deutschland GmbH
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