Publikasi Scopus 2024 per tanggal 30 Juni 2024 (499 artikel)

Syahrani L.; Asih P.B.S.; Bowolaksono A.; Dwiranti A.; Zubaidah S.; Rozi I.E.; Permana D.H.; Bøgh C.; Bangs M.J.; Grieco J.P.; Achee N.L.; Lobo N.F.; Syafruddin D.
Syahrani, Lepa (55014440600); Asih, Puji B. S. (6507080729); Bowolaksono, Anom (57205093224); Dwiranti, Astari (55151437900); Zubaidah, Siti (57216572364); Rozi, Ismail E. (57193863994); Permana, Dendi H. (57218188245); Bøgh, Claus (6602120205); Bangs, Michael J. (7007079698); Grieco, John P. (7003422533); Achee, Nicole L. (6603480149); Lobo, Neil F. (35392948100); Syafruddin, Din (6602774565)
55014440600; 6507080729; 57205093224; 55151437900; 57216572364; 57193863994; 57218188245; 6602120205; 7007079698; 7003422533; 6603480149; 35392948100; 6602774565
Impact of a spatial repellent intervention on Anopheles kdr insecticide resistance allele in Sumba, Indonesia
2024
Malaria Journal
23
1
31
0
Doctoral Program, Department of Biology, Faculty of Mathematics and Natural Sciences, University of Indonesia, Depok, Indonesia; Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, University of Indonesia, Depok, Indonesia; Doctoral Program, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia; Doctoral Program of Biomedical Sciences, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; The Sumba Foundation, Public Health and Malaria Control, Sumba, Indonesia; Public Health and Malaria Control, PT Freeport Indonesia, International SOS, Mimika, Indonesia; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, IN, United States; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Hasanuddin University Medical Research Center (HUMRC), Makassar, Indonesia
Syahrani L., Doctoral Program, Department of Biology, Faculty of Mathematics and Natural Sciences, University of Indonesia, Depok, Indonesia, Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia; Asih P.B.S., Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia; Bowolaksono A., Department of Biology, Faculty of Mathematics and Natural Sciences, University of Indonesia, Depok, Indonesia; Dwiranti A., Department of Biology, Faculty of Mathematics and Natural Sciences, University of Indonesia, Depok, Indonesia; Zubaidah S., Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia; Rozi I.E., Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia, Doctoral Program, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia; Permana D.H., Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia, Doctoral Program of Biomedical Sciences, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Bøgh C., The Sumba Foundation, Public Health and Malaria Control, Sumba, Indonesia; Bangs M.J., Public Health and Malaria Control, PT Freeport Indonesia, International SOS, Mimika, Indonesia; Grieco J.P., Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, IN, United States; Achee N.L., Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, IN, United States; Lobo N.F., Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, IN, United States; Syafruddin D., Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia, Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia, Hasanuddin University Medical Research Center (HUMRC), Makassar, Indonesia
Background: The emergence of insecticide resistance and outdoor transmission in malaria-endemic areas underlines the urgent need to develop innovative tools, such as spatial repellents (SR), that may circumvent this residual transmission. With limited options for effective insecticides, regular resistance monitoring is warranted for selecting and using appropriate tools. This study evaluates the pyrethroid knockdown resistance (kdr) allele before and after implementing a transfluthrin-based spatial repellent (SR) intervention in placebo-treated clusters. Methods: This study looks at the frequency distribution of the kdr allele in Sumba Island from June 2015 to August 2018. Insecticide susceptibility tests were carried out on female Anopheles sp. aged 3–5 days against permethrin 21.5 μg/ml, deltamethrin 12.5 μg/ml, and transfluthrin 10 μg/ml using CDC bottle assay. PCR sequencing of representative samples from adult mosquito collections and insecticide tests revealed the presence of kdr mutations (L1014F and L1014S) in the VGSC gene. Results: A total of 12 Anopheles species, Anopheles tesselatus, Anopheles. aconitus, Anopheles barbirostris, Anopheles kochi, Anopheles annularis, Anopheles maculatus, Anopheles sundaicus, Anopheles flavirostris, Anopheles balabacensis, Anopheles indefinitus, Anopheles subpictus, and Anopheles vagus were analysed. Anopheles vagus and An. sundaicus predominated in the larval populations. Susceptibility assays for all insecticides identified fully susceptible phenotypes in all species examined. Anopheles increasing frequency of kdr mutant alleles during the 3 year SR deployment was observed in both SR-treated and placebo areas, a statistically significant increase occurred in each arm. However, it is unclear how significant SR is in causing the increase in mutant alleles. The L1014S, knockdown resistance east type (kdr-e) allele was detected for the first time among the mosquito samples in this study. The L1014F, knockdown resistance west type (kdr-w) allele and heteroduplex form (wild-type—mutant) were found in almost all Anopheles species examined, including An. vagus, An. aconitus, An. subpictus, An. tesselatus, An. annularis, An. flavirostris and An. sundaicus. Conclusion: The presence of fully susceptible phenotypes over time, along with an increase in the frequency distribution of the L1014F/S mutations post-intervention, suggest drivers of resistance external to the study, including pyrethroid use in agriculture and long-lasting insecticidal nets (LLINs). However, this does not negate possible SR impacts that support resistance. More studies that enable the comprehension of possible SR-based drivers of resistance in mosquitoes need to be conducted. © 2024, The Author(s).
Kdr; L1014F; L1014S; Pyrethroid; Resistance; VGSC
Alleles; Animals; Anopheles; Cyclopropanes; Female; Fluorobenzenes; Indonesia; Insecticide Resistance; Insecticides; Permethrin; deltamethrin; insect repellent; permethrin; placebo; transfluthrin; unclassified drug; cyclopropane derivative; fluorobenzene; insecticide; transfluthrin; allele; Anopheles; Anopheles annularis; Anopheles balabacensis; Anopheles barbirostris; Anopheles flavirostris; Anopheles indefinitus; Anopheles kochi; Anopheles maculatus; Anopheles subpictus; Anopheles sundaicus; Anopheles tesselatus; Anopheles vagus; Anopheles. aconitus; Article; controlled study; gene; gene frequency; gene knockdown; gene mutation; genetic susceptibility; Indonesia; insecticide resistance; kdr gene; nonhuman; phenotype; polymerase chain reaction; spatial analysis; allele; animal; female; ge
District health departments of Southwest and West Sumba; East Nusa Tenggara Province; Eijkman Research Center for Molecular Biology; Government of Indonesia National Research and Innovation Agency; Health Research Organization; Bill and Melinda Gates Foundation, BMGF; University of Notre Dame, ND, (OPP1081737); Badan Riset dan Inovasi Nasional, BRIN; Universitas Hasanuddin; Ministry of Health of the Republic of Indonesia
Funding text 1: The authors are grateful for the support of the Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia; The University of Hasanuddin, Makassar, Indonesia; the Ministry of Health Republic of Indonesia; District health departments of Southwest and West Sumba, and East Nusa Tenggara Province. We appreciate the contribution of
BioMed Central Ltd
14752875
38254131
Article
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