Publikasi Scopus 2024 per tanggal 30 Juni 2024 (499 artikel)

Hardiany N.S.; Dewi P.K.K.; Dewi S.; Tejo B.A.
Hardiany, Novi Silvia (57192910605); Dewi, Putri Krishna Kumara (58795085300); Dewi, Syarifah (57192904541); Tejo, Bimo A. (6506268507)
57192910605; 58795085300; 57192904541; 6506268507
Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats
2024
Scientific Reports
14
1
603
0
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Medical Biochemistry Division, Department of Biomedical Science, Faculty of Medicine, Universitas Pendidikan Ganesha, Bali, 81116, Indonesia; Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, 43400, Malaysia
Hardiany N.S., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Dewi P.K.K., Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Medical Biochemistry Division, Department of Biomedical Science, Faculty of Medicine, Universitas Pendidikan Ganesha, Bali, 81116, Indonesia; Dewi S., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Tejo B.A., Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, 43400, Malaysia
In this study, the potential neuroprotective ability of coriander seeds (Coriandrum sativum L.) ethanolic extract (CSES) as a neuroprotectant agent in the brains of high-fat diet-induced obese rats was analyzed. The study investigated how CSES impacts oxidative stress markers (i.e., malondialdehyde/MDA, glutathione/GSH and catalase), inflammation marker (i.e., Interleukin-6/IL-6), cellular senescence markers (i.e., senescence-associated β-galactoside/SA-β-Gal activity and p16), brain damage marker (i.e., Neuron-specific Enolase/NSE), and neurogenesis markers (i.e., mature Brain-derived Neurotropic Factor/BDNF, pro-BDNF, and mature/pro-BDNF ratio). Male adult Wistar rats were fed a high-fat diet and given CSES once daily, at 100 mg/kg body weight, for 12 weeks. CSES significantly reduced MDA concentration (p = < 0.001), SA-β-Gal activity (p = 0.010), and increased GSH concentration (p = 0.047) in the brain of obese rats; however, the decrease of IL-6, NSE, and p16 as well as the increase of catalase specific activity and BDNF expression were not significant. Moreover, the mature/pro-BDNF ratio was significantly higher in the brains of non-obese rats, both given the control diet and the high-fat diet compared to the control. Our results suggest that obese rats benefited from consuming CSES, showing improved oxidative stress levels, reduced cellular senescence and increased endogenous antioxidants, making CSES a potential neuroprotective agent. © 2024, The Author(s).
Animals; Brain; Brain-Derived Neurotrophic Factor; Catalase; Coriandrum; Ethanol; Glutathione; Interleukin-6; Male; Neuroprotective Agents; Obesity; Rats; Rats, Wistar; Seeds; alcohol; brain derived neurotrophic factor; catalase; glutathione; interleukin 6; neuroprotective agent; animal; brain; Coriandrum; male; obesity; plant seed; rat; Wistar rat
HIBAH PUTI Universitas Indonesia 2023, (NKB-392/UN2.RST/HKP.05.00/2023)
This research received funding from HIBAH PUTI Universitas Indonesia 2023 (grant number: NKB-392/UN2.RST/HKP.05.00/2023).
Nature Research
20452322
38182767
Article
Q1
973
4401