Publikasi Scopus 2024 per tanggal 30 Juni 2024 (499 artikel)

Karyanti M.R.; Uiterwaal C.S.P.M.; Hadinegoro S.R.; Widyahening I.S.; Saldi S.R.F.; Heesterbeek J.A.P.H.; Hoes A.W.; Bruijning-Verhagen P.
Karyanti, Mulya Rahma (56290680800); Uiterwaal, Cuno S P M (59148037600); Hadinegoro, Sri Rezeki (56893685800); Widyahening, Indah Suci (54893154400); Saldi, Siti Rizny F (55201904000); Heesterbeek, J A P Hans (59134733500); Hoes, Arno W. (35370614300); Bruijning-Verhagen, Patricia (55175644800)
56290680800; 59148037600; 56893685800; 54893154400; 55201904000; 59134733500; 35370614300; 55175644800
The Value of Warning Signs From the WHO 2009 Dengue Classification in Detecting Severe Dengue in Children
2024
The Pediatric infectious disease journal
43
7
630
634
4
0
From the Department of Child Health, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Clinical Epidemiology and Evidence-Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands
Karyanti M.R., From the Department of Child Health, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands; Uiterwaal C.S.P.M., Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands; Hadinegoro S.R., From the Department of Child Health, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Widyahening I.S., Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Saldi S.R.F., Clinical Epidemiology and Evidence-Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Heesterbeek J.A.P.H., Department of Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands; Hoes A.W., Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands; Bruijning-Verhagen P., Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands
BACKGROUND: World Health Organization proposed 7 warning signs to identify the risk of severe dengue in 2009. This study aimed to evaluate the value of these warning signs in detecting severe dengue in children. MATERIAL AND METHODS: A cross-sectional study was conducted utilizing data of children with clinical dengue infection obtained from medical records between January 2009 and December 2018 in Jakarta. Children with confirmed dengue were analyzed and stratified into 3 age groups: infants less than 1 year old, children 1-14 years and adolescents 15-18 years of age. Positive predictive value, negative predictive value (NPV), sensitivity and specificity of each warning sign present or absent on admission in detecting severe dengue were computed. RESULTS: Six hundred ninety-nine children with clinical dengue infection were enrolled, among whom 614 (87.8%) had confirmed dengue infection, either by antigen or antibody serological tests. Severe dengue occurred in 211/614 (34.4%) cases. In infants, important warning signs on admission to detect or exclude severe dengue were liver enlargement (NPV 80.8%) and clinical fluid accumulation (NPV 75%). In children and adolescents, warning sign with highest NPV (in children 76.6% and in adolescents 91.9%) was increase in hematocrit concurrent with a rapid decrease in platelet count. Other warning signs with high NPV values in children were abdominal pain (72%), vomiting (70%), clinical fluid accumulation (69.3%), and in adolescents' abdominal pain (80.7%), vomiting (75.7%), clinical fluid accumulation (82.7%). NPVs increase with more than 1 warning sign in all age groups. CONCLUSION: In infants, liver enlargement or clinical fluid accumulation are important warning signs for severe dengue, when both are absent, severe dengue is unlikely. In older children and adolescents, an increase in hematocrit with the concurrent rapid decrease in platelet count is most discriminative; followed by the absence of abdominal pain, vomiting or fluid accumulation are unlikely severe dengue. Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.
Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Female; Humans; Infant; Male; Sensitivity and Specificity; Severe Dengue; World Health Organization; adolescent; child; cross-sectional study; diagnosis; female; human; infant; male; preschool child; sensitivity and specificity; severe dengue; World Health Organization
15320987
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