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Publikasi Scopus 2024 per tanggal 30 November 2024 (994 artikel)
Publikasi Scopus 2024 per tanggal 30 November 2024 (994 artikel)
Djunaedy, Hanif A.K. (59197222700); Febinia, Clarissa A. (55195897900); Hamers, Raph L. (23034345900); Baird, Kevin (15921267800); Elyazar, Iqbal (6506894785); Thuong, Nguyen Thuy Thuong (14833718800); Trimarsanto, Hidayat (38362695700); Malik, Safarina G. (7402973374); Thwaites, Guy (6603796838); van Crevel, Reinout (6603956378); Alisjahbana, Bachti (6506944516); Chaidir, Lidya (55533200400); Ashton, Philip M. (56115413200)
A description of lineage 1 Mycobacterium tuberculosis from papua, Indonesia
2024
Tuberculosis
149
102568
0
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85204736865&doi=10.1016%2fj.tube.2024.102568&partnerID=40&md5=a455ded243f8867bf94c3f9d2e31f279
Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Research Center for Care and Control of Infectious Diseases, Universitas Padjadjaran, Bandung, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Division of Biological Anthropology, Department of Archaeology, University of Cambridge, Cambridge, United Kingdom; Oxford University Clinical Research Unit Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mochtar Riady Institute for Nanotechnology, Banten, Indonesia; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Menzies School of Health Research, Darwin, Australia; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Department of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Center for Translational Biomarker Research, Universitas Padjadjaran, Bandung, Indonesia; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom
Indonesia has the third highest number of tuberculosis (TB) patients infected with Mycobacterium tuberculosis (MTB) Lineage 1 (L1). Most of these MTB L1 cases can be found in Indonesia's remote easternmost province of Papua, one of Indonesia's most underdeveloped provinces with a particularly high burden for TB. In this study, we sequenced and described 42 MTB L1 isolates from a well-characterized cohort of patients. We found a genetically diverse MTB L1 population with no association between pathogen genetic relatedness and place of residence or pathogen genetic relatedness and patient ethnicity, which could reflect mixing between different locales and ethnicities or our low sampling fraction. Only a small number showed genetic variants associated with drug resistance (5/42, 11.9 %), probably due to a lack of effective treatment programs. The Papuan isolates showed similarities to other Island Southeast Asian Countries due to the high proportion of L1.2.1.2.1 (30/42, 71.4 %), especially East Timor and the Philippines. This study fills a research gap of MTB L1 in Indonesian Papua and should serve as a stepping stone for further research in the region. © 2024 The Authors
Wellcome Trust, WT, (106680)
This project was supported by Wellcome, grant number 106680.
Churchill Livingstone
14729792
Article
Q2
605
8864