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Publikasi Scopus 2024 per tanggal 30 September 2024 (820 artikel)
Publikasi Scopus 2024 per tanggal 30 September 2024 (820 artikel)
Manurung, Mikhael D. (57210737315); Sonnet, Friederike (57212529488); Hoogerwerf, Marie-Astrid (55210214000); Janse, Jacqueline J. (55959038600); Kruize, Yvonne (6602745057); Bes-Roeleveld, Laura de (59220077400); König, Marion (57183759300); Loukas, Alex (7006573927); Dewals, Benjamin G. (8883647300); Supali, Taniawati (6602742029); Jochems, Simon P. (57209686200); Roestenberg, Meta (16305767300); Coppola, Mariateresa (55586642100); Yazdanbakhsh, Maria (7006269286)
Controlled human hookworm infection remodels plasmacytoid dendritic cells and regulatory T cells towards profiles seen in natural infections in endemic areas
2024
Nature Communications
15
1
5960
0
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85198640521&doi=10.1038%2fs41467-024-50313-0&partnerID=40&md5=08405f618c28132db8822f4b19fbfda8
Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands; Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Australia; Laboratory of Immunology-Vaccinology, FARAH, University of Liège, Liège, Belgium; Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
Hookworm infection remains a significant public health concern, particularly in low- and middle-income countries, where mass drug administration has not stopped reinfection. Developing a vaccine is crucial to complement current control measures, which necessitates a thorough understanding of host immune responses. By leveraging controlled human infection models and high-dimensional immunophenotyping, here we investigated the immune remodeling following infection with 50 Necator americanus L3 hookworm larvae in four naïve volunteers over two years of follow-up and compared the profiles with naturally infected populations in endemic areas. Increased plasmacytoid dendritic cell frequency and diminished responsiveness to Toll-like receptor 7/8 ligand were observed in both controlled and natural infection settings. Despite the increased CD45RA+ regulatory T cell (Tregs) frequencies in both settings, markers of Tregs function, including inducible T-cell costimulatory (ICOS), tumor necrosis factor receptor 2 (TNFR2), and latency-associated peptide (LAP), as well as in vitro Tregs suppressive capacity were higher in natural infections. Taken together, this study provides unique insights into the immunological trajectories following a first-in-life hookworm infection compared to natural infections. © The Author(s) 2024.
Adult; Animals; Dendritic Cells; Endemic Diseases; Female; Hookworm Infections; Humans; Immunophenotyping; Male; Necator americanus; Necatoriasis; T-Lymphocytes, Regulatory; Young Adult; CD45RA antigen; inducible T cell costimulator ligand; latency associated peptide; toll like receptor 7; toll like receptor 8; tumor necrosis factor receptor 2; biostimulation; cell component; infectious disease; public health; adult; Article; CD4+ T lymphocyte; cell compartmentalization; cell count; cell expansion; clinical article; controlled study; endemic disease; follow up; hookworm infection; human; human cell; immunoregulation; larva; lymphocyte count; lymphocyte function; Necator americanus; plasmacytoid dendritic cell; regulatory T lymphocyte; animal; dendritic cell; endemic disease; female; hookwo
Indonesian Endowment Fund for Education; Dioraphte Foundation; European Commission, EC; Fonds De La Recherche Scientifique - FNRS, FNRS; NWO; LPDP, (S-1598/LPDP.3/2016)
We would like to thank the Flow Cytometry Core Facility at Leiden University Medical Center for assistance with our flow and mass cytometry experiments. This study is part of the EDCTP2 programme supported by the European Union. The Controlled Human Hookworm Infection in Leiden (CHHIL) trial was funded by the Dioraphte Foundation and by NWO Spinoza prize of M.Y. M.D.M. is funded by the Indonesian
Nature Research
20411723
39013877
Article
Q1
4887
297