Riset dan Pengabdian Masyarakat
Do Research Sosial Service and Innovation
Publikasi Scopus 2024 per tanggal 30 September 2024 (820 artikel)
Publikasi Scopus 2024 per tanggal 30 September 2024 (820 artikel)
Simargi, Yopi (57770185600); Turana, Yuda (56083326000); Icksan, Aziza Ghanie (57194332884); Harahap, Alida Roswita (6507325543); Siste, Kristiana (55644113100); Mansyur, Muchtaruddin (37085506800); Damayanti, Triya (36058523500); Maryastuti, Maryastuti (59248478700); Fazharyasti, Vininta (57224900665); Dewi, Indah Puspita (59248465600); Ramli, Yetty (57197869497); Prasetyo, Marcel (57192905252); Rumende, Cleopas Martin (14325966300)
A Multicenter Study of COPD and Cognitive Impairment: Unraveling the Interplay of Quantitative CT, Lung Function, HIF-1α, and Clinical Variables
2024
International Journal of COPD
19
1741
1753
12
0
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85200531065&doi=10.2147%2fCOPD.S466173&partnerID=40&md5=f1b8fe53e81b926e98cc80eac8270e44
Doctoral Program in Medical Science, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Radiology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Department of Radiology, Atma Jaya Hospital, Jakarta, Indonesia; Department of Neurology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Department of Radiology, Prima Indonesia University, Medan, Indonesia; Department of Psychiatry, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Psychiatry, Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Department of Community, Occupational and Family Medicine, Faculty of Medicine, University of Indonesia, Depok, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, National Respiratory Center Persahabatan Hospital, Jakarta, Indonesia; Department of Radiology, National Respiratory Center Persahabatan Hospital, Jakarta, Indonesia; Department of Radiology, Gatot Soebroto Army Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine and Health, University of Muhammadiyah Jakarta, Jakarta, Indonesia; Department of Radiology, Jakarta Islamic Hospital Cempaka Putih, Jakarta, Indonesia; Department of Neurology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department Neurology, Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Radiology, Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Radiology, Prima Indonesia University, Medan, Indonesia; Family Medicine, Faculty of Medicine, University of Indonesia, Depok, Indonesia; of Muhammadiyah Jakarta, Jakarta, Indonesia
Purpose: The exact link between cognitive impairment (CI) and chronic obstructive pulmonary disease (COPD) is still limited. Thus, we aim to find the relationship and interaction of quantitative CT (QCT), lung function, HIF-1α, and clinical factors with the development of CI among COPD patients. Patients and Methods: A cross-sectional multicentre study was conducted from January 2022 to December 2023. We collected clinical data, spirometry, CT images, and venous blood samples from 114 COPD participants. Cognitive impairment assessment using the Montreal Cognitive Assessment Indonesian version (MoCA-Ina) with a cutoff value 26. The QCT analysis consists of lung density, airway wall thickness, pulmonary artery-to-aorta ratio (PA:A), and pectoralis muscles using 3D Slicer software. Serum HIF-1α analysis was performed using ELISA. Results: We found significant differences between %LAA−950, age, COPD duration, BMI, FEV1 pp, and FEV1 /FVC among GOLD grades I–IV. Only education duration was found to correlate with CI (r = 0.40; < 0.001). We found no significant difference in HIF-1α among GOLD grades (p = 0.149) and no correlation between HIF-1α and CI (p = 0.105). From multiple linear regression, we observed that the MoCA-Ina score was influenced mainly by %LAA−950 (p = 0.02) and education duration (p = 0.01). The path analysis model showed both %LAA and education duration directly and indirectly through FEV1 pp contributing to CI. Conclusion: We conclude that the utilization of QCT parameters is beneficial as it can identify abnormalities and contribute to the development of CI, indicating its potential utility in clinical decision-making. The MoCA-Ina score in COPD is mainly affected by %LAA−950 and education duration. Contrary to expectations, this study concludes that HIF-1α does not affect CI among COPD patients. © 2024 Simargi et al.
Aged; Biomarkers; Cognition; Cognitive Dysfunction; Cross-Sectional Studies; Female; Forced Expiratory Volume; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lung; Male; Middle Aged; Predictive Value of Tests; Pulmonary Disease, Chronic Obstructive; Risk Factors; Spirometry; Tomography, X-Ray Computed; Vital Capacity; hypoxia inducible factor 1alpha; biological marker; HIF1A protein, human; hypoxia inducible factor 1alpha; adult; Article; blood sampling; body mass; brain surgery; chronic obstructive lung disease; clinical decision making; cognition; cognitive defect; computer assisted tomography; cross-sectional study; enzyme linked immunosorbent assay; female; forced expiratory volume; forced vital capacity; Generalized Anxiety Disorder-7; human; image analysis; image processing; lang
Dove Medical Press Ltd
11769106
39099608
Article