Publikasi Scopus 2024 per tanggal 30 September 2024 (820 artikel)

Publikasi Scopus 2024 per tanggal 30 September 2024 (820 artikel)

Nurkolis F.; Kurniatanty I.; Wiyarta E.; Permatasari H.K.; Mayulu N.; Taslim N.A.; Tjandrawinata R.R.; Hardinsyah H.; Tallei T.E.; Tsopmo A.; Radu S.; Hadinata E.; Kim B.; Ribeiro R.I.M.A.; Syahputra R.A.
Nurkolis, Fahrul (57226728465); Kurniatanty, Isma (56951090800); Wiyarta, Elvan (57221521342); Permatasari, Happy Kurnia (57194728338); Mayulu, Nelly (57303104200); Taslim, Nurpudji Astuti (57194571794); Tjandrawinata, Raymond Rubianto (6603266135); Hardinsyah, Hardinsyah (56586054400); Tallei, Trina Ekawati (57193317686); Tsopmo, Apollinaire (6602260089); Radu, Son (57217179810); Hadinata, Edwin (59294064400); Kim, Bonglee (51663469700); Ribeiro, Rosy Iara Maciel Azambuja (59279277900); Syahput
57226728465; 56951090800; 57221521342; 57194728338; 57303104200; 57194571794; 6603266135; 56586054400; 57193317686; 6602260089; 57217179810; 59294064400; 51663469700; 59279277900; 57216124200
Identification of novel functional compounds from forest onion and its biological activities against breast cancer
2024
Journal of Agriculture and Food Research
18
101362
0
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85201758813&doi=10.1016%2fj.jafr.2024.101362&partnerID=40&md5=54f4495cf330b0fe5dce202636b60d1b
Department of Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta, 55281, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo National Hospital, Jakarta, 10430, Indonesia; Department of Biochemistry and Biomolecular, Faculty of Medicine, University of Brawijaya, Malang, 65145, Indonesia; Department of Nutrition, Faculty of Health Science, Muhammadiyah Manado University, Manado, 95249, Indonesia; Division of Clinical Nutrition, Department of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Department of Biotechnology, Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, 12930, Indonesia; Division of Applied Nutrition, Department of Community Nutrition, Faculty of Human Ecology, IPB University, West Java, Bogor, 16680, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sam Ratulangi, Manado, 95115, Indonesia; Food Science Program, Department of Chemistry, Institute of Biochemistry, Carleton University, 1125 Colonel by Drive, Ottawa, K1S 5B6, ON, Canada; Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, UPM Serdang, Selangor, 43400, Malaysia; Internal Medicine, Hermina Pasuruan Hospital, Pasuruan, East Java, 67181, Indonesia; Department of Pathology, College of Korean Medicine, Kyung Hee University, Seou, 02447, South Korea; Experimental Pathology Laboratory, Midwest Campus, Federal University of São João del-Rei, Divinópolis, Brazil; Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia
Nurkolis F., Department of Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta, 55281, Indonesia; Kurniatanty I., Department of Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta, 55281, Indonesia; Wiyarta E., Department of Neurology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo National Hospital, Jakarta, 10430, Indonesia; Permatasari H.K., Department of Biochemistry and Biomolecular, Faculty of Medicine, University of Brawijaya, Malang, 65145, Indonesia; Mayulu N., Department of Nutrition, Faculty of Health Science, Muhammadiyah Manado University, Manado, 95249, Indonesia; Taslim N.A., Division of Clinical Nutrition, Department of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Tjandrawinata R.R., Department of Biotechnology, Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, 12930, Indonesia; Hardinsyah H., Division of Applied Nutrition, Department of Community Nutrition, Faculty of Human Ecology, IPB University, West Java, Bogor, 16680, Indonesia; Tallei T.E., Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sam Ratulangi, Manado, 95115, Indonesia; Tsopmo A., Food Science Program, Department of Chemistry, Institute of Biochemistry, Carleton University, 1125 Colonel by Drive, Ottawa, K1S 5B6, ON, Canada; Radu S., Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, UPM Serdang, Selangor, 43400, Malaysia; Hadinata E., Internal Medicine, Hermina Pasuruan Hospital, Pasuruan, East Java, 67181, Indonesia; Kim B., Department of Pathology, College of Korean Medicine, Kyung Hee University, Seou, 02447, South Korea; Ribeiro R.I.M.A., Experimental Pathology Laboratory, Midwest Campus, Federal University of São João del-Rei, Divinópolis, Brazil; Syahputra R.A., Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia
The discovery of new molecules from natural sources for the treatment of tumors such as breast cancers is of importance for the development of functional foods and to the pharmaceutical industry. A natural resource with potential activity against breast cancer is forest onion, Eleutherine bulbosa (Mill.) Urb., but the identity of its active constituents and their mechanisms of action remain unexplored. Therefore, this study focuses on metabolite profiling, in silico or pharmacoinformatic activity and mechanisms, as well as advanced validation on in vitro cell lines. Ten compounds identified in E. bulbosa bulb ethanolic extract (EBE) showed cancer receptor and radical inhibitory activity via network pharmacology and molecular docking simulation. The most promising compound was avenasterol binding PARP-1, HER2, iNOS receptors with values of −11.26, −8.34, and −9.17 μg/mL, respectively. EBE and avenasterol had a smaller EC50 value, or higher potency, than the control antioxidant Trolox in radical scavenging tests with ABTS and DPPH. In line with the in silico study, EBE and avenasterol showed antiproliferative activity against human breast cancer MCF-7 with LD50 217.8 μg/mL, with relatively low cytotoxicity to normal MCF-10A cells (LD50 > 1000 μg/mL). The antiproliferative mechanism of EBE on MCF-7 was associated with downregulation of TGF-β, HER2, PI3K, and AKT which are known tumor activators. Significant (p < 0.05) upregulation of tumor suppressor gene miR-29a-3p in MCF-7 was observed after treatment with EBE in a dose-dependent manner. © 2024 The Authors
Anticancer; Antioxidant capability; Avenasterol; Forest onion; Functional food; MCF-7; Natural product; Network pharmacology; PARP1
Universitas Sumatera Utara, USU
This study was funded by Universitas Sumatera Utara.
Elsevier B.V.
26661543
Article
Q1
809
6128

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