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Publikasi Scopus 2024 per tanggal 30 September 2024 (820 artikel)
Publikasi Scopus 2024 per tanggal 30 September 2024 (820 artikel)
Tirtayasa, Pande Made Wisnu (56245176500); Situmorang, Gerhard Reinaldi (57190001213); Duarsa, Gede Wirya Kusuma (57203942850); Mahadita, Gede Wira (57223259458); Ghinorawa, Tanaya (57219246610); Myh, Etriyel (59236032800); Nugroho, Eriawan Agung (57204465148); Kandarini, Yenny (57203942868); Rodjani, Arry (6504653529); Rasyid, Nur (56245069300)
Risk factors of delayed graft function following living donor kidney transplantation: A meta-analysis
2024
Transplant Immunology
86
102094
0
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85199718281&doi=10.1016%2fj.trim.2024.102094&partnerID=40&md5=93b9eff731cfe0e520d271a33a5c053a
Department of Urology, Faculty of Medicine, Universitas Udayana, Universitas Udayana Teaching Hospital, Bali, Indonesia; Department of Urology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Department of Urology, Faculty of Medicine, Universitas Udayana, Prof. Dr. I.G.N.G. Ngoerah General Hospital, Bali, Indonesia; Department of Nephrology, Faculty of Medicine, Universitas Udayana, Prof. Dr. I.G.N.G. Ngoerah General Hospital, Bali, Indonesia; Department of Urology, Faculty of Medicine, Universitas Gadjah Mada, Dr. Sardjito General Hospital, Yogyakarta, Indonesia; Department of Urology, Faculty of Medicine, Universitas Andalas, Dr. M.Djamil General Hospital, Padang, Indonesia; Department of Urology, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi General Hospital, Semarang, Indonesia
Introduction: Delayed graft function (DGF) is a common condition that necessitates dialysis during the first week after transplantation. Although DGF rarely occurs following living-donor kidney transplantation (LDKT), it may eventually lead to acute or chronic graft rejection. This study aimed to assess the risk factors for DGF in patients who underwent LDKT. Methods: A systematic review and meta-analysis of studies published before August 2022 was conducted using the PubMed, Science Direct, Cochrane, and Directory of Open Access Journal (DOAJ) databases. The review included studies that assessed the incidence of DGF following LDKT, and examined its risk factors, while excluding studies involving deceased donors. Potential risk factors were analyzed using pooled mean differences or odds ratios with 95% confidence intervals (CIs). Review Manager 5.3 was used for the meta-analysis. Results: Among the 13 included studies, 3685 cases of DGF were identified in a total of 113,261 patients (3.25%). Potential risk factors for DGF following LDKT were examined across several aspects, including donor, recipient, donor/recipient relationship, and immunological and intraoperative factors. The identified risk factors included older donors (P = 0.07), male recipients (P < 0.0001), higher recipient body mass index (BMI) (P < 0.0001), non-white recipients (P < 0.0001), pre-existing diabetes (P < 0.0001), pre-existing hypertension (P = 0.01), history of dialysis (P < 0.0001), re-transplantation (P = 0.004), unrelated donor/recipient (P = 0.02), ABO incompatibility (P < 0.0001), higher panel reactive antibody (PRA) levels (P < 0.0001), utilization of right kidney (P < 0.0001), and longer cold ischemia time (CIT) (P = 0.004). Conclusion: Several factors related to the donor, recipient, donor/recipient relationship, and immunological and intraoperative aspects were identified as potential risk factors for the development of DGF following LDKT. Addressing and optimizing these factors may improve the long-term outcomes of LDKT. © 2024 Elsevier B.V.
Delayed Graft Function; Female; Graft Rejection; Humans; Kidney Transplantation; Living Donors; Male; Risk Factors; panel reactive antibody; acute graft rejection; age; antibody blood level; blood group ABO incompatibility; body mass; chronic graft rejection; cold ischemia time; confidence interval; delayed graft function; diabetes mellitus; dialysis; graft recipient; human; hypertension; immunology; incidence; intraoperative period; kidney transplantation; living donor; meta analysis; odds ratio; patient history of transplantation; related donor; retransplantation; Review; risk factor; sex difference; systematic review; unrelated donor; delayed graft function; epidemiology; female; graft rejection; male; risk factor
DIPA PNBP Universitas Udayana, (TA-2023)
The first author received funding from DIPA PNBP Universitas Udayana TA-2023 .
Elsevier B.V.
9663274
39053613
Review