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Publikasi Scopus 2024 per tanggal 31 Agustus 2024 (707 artikel)
Publikasi Scopus 2024 per tanggal 31 Agustus 2024 (707 artikel)
Kalista, Kemal Fariz (57200425631); Rahma, Hanum Citra Nur (59276020800); Tahapary, Dicky Levenus (55944492500); Nababan, Saut Horas (57205443199); Jasirwan, Chynthia Olivia Maurine (55192478000); Kurniawan, Juferdy (57193251655); Lesmana, Cosmas Rinaldi Adithya (8977683000); Sulaiman, Andri Sanityoso (57833687400); Hasan, Irsan (12776850800); Gani, Rino (23495930300)
Persistent hypoglycemia in patients with liver cancer
2024
Endocrinology, Diabetes and Metabolism Case Reports
2024
3
e230077
0
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85201524828&doi=10.1530%2fEDM-23-0077&partnerID=40&md5=206316cfb89094f7e24f63dc21050499
Division of Hepatobiliary, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia
Hypoglycemia is one of the paraneoplastic syndrome manifestations that arise from primary and secondary liver cancer. Hypoglycemia usually presents in the late stage of the disease and indicates a poor prognosis. This case series displays the characteristics profile of patients with primary and secondary liver cancer who are presented with hypoglycemia in a tertiary referral hospital in Indonesia. The study included 41 liver cancer patients who were presented with hypoglycemia. Hepatocellular carcinoma was diagnosed in 51.2% of patients, metastatic liver disease in 14.6% of patients, and undiagnosed liver cancer in 34.1% of patients. The mean age was 47.7 years with male predominance (65.9%). Jaundice was found in 58.5% and hepatomegaly in 70.7% of patients. The mean (± S.D.) initial blood glucose was 42.15 ± 17.11 mg/dL and the Child–Pugh score was 9.93 ± 2.11. Based on imaging, tumor diameter was 12.6 ± 6.9 cm, multiple (61%), and involving both lobes (61%). Treatments for hypoglycemia included oral/enteral feeding, intravenous dextrose, and steroids. No treatment was given for the cancer because all patients were in an advanced stage. The treatment resulted in 41.5% blood glucose being controlled, 56.1% refractory, and 2.4% persistent. Mortality was 70.7% and in average occurred 5.76 ± 4.99 days after hypoglycemia. The mainstay of treatment in these cases is treating the tumor with cytoreduction. However, it was difficult to do cytoreduction because the tumor was already in an advanced stage. Beneficial supportive treatments for maintaining normal blood glucose are frequent meals, dextrose infusion, steroids, and glucagon. © 2024 the author(s).
alanine aminotransferase; alkaline phosphatase; aspartate aminotransferase; bilirubin; creatinine; glucagon; glucose; hepatitis B surface antigen; steroid; Article; clinical article; computer assisted tomography; echography; enteric feeding; female; follow up; food intake; glucose blood level; glucose intake; hepatomegaly; human; hypoglycemia; jaundice; lipolysis; liver cancer; liver cell; liver cell carcinoma; liver cirrhosis; liver metastasis; male; non insulin dependent diabetes mellitus; nuclear magnetic resonance imaging; outcome assessment; persistent hypoglycemia; tumor volume
BioScientifica Ltd.
20520573
Article
Q3
282
15725