Publikasi Scopus 2024 per tanggal 31 Januari 2024 (57 artikel)

Rahayatri T.H.; Oswari H.; Kekalih A.; Harahap A.; Hendarto A.; Munasir Z.; Setiabudy R.; Taher A.
Rahayatri, Tri H. (57188549965); Oswari, Hanifah (12777323800); Kekalih, Aria (55633562200); Harahap, Alida (6507325543); Hendarto, Aryono (57204142249); Munasir, Zakiudin (7801694370); Setiabudy, Rianto (6602316235); Taher, Akmal (7005269743)
57188549965; 12777323800; 55633562200; 6507325543; 57204142249; 7801694370; 6602316235; 7005269743
Granulocyte Colony-stimulating Factor Improves Innate Immunity in Pediatric Pretransplant Patients
2024
Journal of Clinical and Experimental Hepatology
14
2
101282
0
Faculty of Medicine, Universitas Indonesia, Department of Pediatric Surgery, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Department of Pediatrics, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Department of Community Medicine, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Department of Pharmacology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Department of Urology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Rahayatri T.H., Faculty of Medicine, Universitas Indonesia, Department of Pediatric Surgery, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Oswari H., Faculty of Medicine, Universitas Indonesia, Department of Pediatrics, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kekalih A., Faculty of Medicine, Universitas Indonesia, Department of Community Medicine, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harahap A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Hendarto A., Faculty of Medicine, Universitas Indonesia, Department of Pediatrics, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Munasir Z., Faculty of Medicine, Universitas Indonesia, Department of Pediatrics, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Setiabudy R., Faculty of Medicine, Universitas Indonesia, Department of Pharmacology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Taher A., Faculty of Medicine, Universitas Indonesia, Department of Urology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Background: Children with decompensated cirrhosis (DC) awaiting LT suffer from infection linked to high pediatric end-stage liver disease (PELD) scores and mortality. Granulocyte colony-stimulating factor (G-CSF) therapy has shown promising results in adult DC. Our study investigated G-CSF as an optimizing treatment for pre-transplant DC, exploring its effect on cytokine activity. Methods: An open-label, randomized controlled trial included DC patients aged 3 months-12 years. The intervention group (n=26) received 12 G-CSF courses injected subcutaneously (5 μg/kg/day) plus DC standard medical treatment (SMT). The control group (n = 24) received SMT. We obtained PELD scores, tumor necrosis factor (TNF)-α, interleukin (IL)-10, hepatocyte growth factor (HGF), CD34+ mobilization, liver function, leukocyte and neutrophil counts. Infection and side effects were documented. Results: There was no significant difference in PELD scores between the groups after 3 months G-CSF treatment. Decreased TNF-α (p < 0.001) and increased IL-10 and HGF (p = 0.003 for both markers) were shown 1 month following G-CSF treatment. Alanine aminotransferase (ALT) levels improved significantly (p = 0.038). Significant increase in leucocyte and neutrophil counts (p < 0.001) and a lower incidence of sepsis (p = 0.04) were shown after intervention. There was no significant difference in survival (p = 0.372). Conclusion: Following 3 months of G-CSF treatment, PELD scores did not show significant improvement. G-CSF reversed the cytokine profiles in DC, resulting in reduced TNF-α and increased IL-10. HGF significantly improved, indicating hepatic regeneration. Significantly decreased occurrence of sepsis following G-CSF treatment indicated improved clinical outcome. © 2023 Indian National Association for Study of the Liver
cytokine; G-CSF; pediatric cirrhosis
alanine aminotransferase; alpha tocopherol; CD34 antigen; cytokine; granulocyte colony stimulating factor; interleukin 10; leucogen; retinol; scatter factor; tumor necrosis factor; ursodeoxycholic acid; vitamin K group; acute gastroenteritis; alanine aminotransferase blood level; alanine aminotransferase level; Article; child; clinical article; clinical outcome; controlled study; coughing; cytomegalovirus infection; decompensated liver cirrhosis; enteric feeding; epistaxis; female; fever; follow up; human; innate immunity; leukocyte count; leukocytosis; liver cirrhosis; liver function; liver function test; liver regeneration; male; measles; Model For End Stage Liver Disease Score; neutrophil count; open study; outcome assessment; pneumonia; preschool child; prospective study; protein funct
Kementerian Riset Teknologi Dan Pendidikan Tinggi Republik Indonesia, (NKB-180/UN2.RST/HKP.05.00/2020)
This research was funded by the Ministry of Research Technology and Higher Education (NKB-180/UN2.RST/HKP.05.00/2020).
Elsevier B.V.
09736883
Article
Q3
655
7744