Publikasi Scopus 2024 per tanggal 31 Maret 2024 (233 artikel)

Tjandra K.C.; Novriansyah R.; Sudiasa I.N.S.; Ar A.; Rahmawati N.A.D.; Dilogo I.H.
Tjandra, Kevin Christian (57866159800); Novriansyah, Robin (57221099996); Sudiasa, I. Nyoman Sebastian (58819987400); Ar, Ardiyana (58819254700); Rahmawati, Nurul Azizah Dian (58820735000); Dilogo, Ismail Hadisoebroto (56161962800)
57866159800; 57221099996; 58819987400; 58819254700; 58820735000; 56161962800
Modified Mesenchymal stem cell, platelet-rich plasma, and hyaluronic acid intervention in early stage osteoarthritis: A systematic review, meta-analysis, and meta-regression of arthroscopic-guided intra-articular approaches
2024
PLoS ONE
19
3 March
e0295876
0
Department of Medicine, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia; Kariadi General Hospital, Semarang, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Diopnegoro, Semarang, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Stem Cell and Tissue Engineering Research Cluster Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia
Tjandra K.C., Department of Medicine, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia, Kariadi General Hospital, Semarang, Indonesia; Novriansyah R., Kariadi General Hospital, Semarang, Indonesia, Department of Surgery, Faculty of Medicine, Universitas Diopnegoro, Semarang, Indonesia; Sudiasa I.N.S., Department of Medicine, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia, Kariadi General Hospital, Semarang, Indonesia; Ar A., Department of Medicine, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia, Kariadi General Hospital, Semarang, Indonesia; Rahmawati N.A.D., Department of Medicine, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia, Kariadi General Hospital, Semarang, Indonesia; Dilogo I.H., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Stem Cell and Tissue Engineering Research Cluster Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia, Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia
Background Mesenchymal stem cells (MSCs) hold promise for osteoarthritis (OA) treatment, potentially enhanced by combining them with platelet-rich plasma (PRP) and hyaluronic acid (HA). This study aimed to assess the synergy of MSCs, PRP, and varying HA doses, and determine optimal MSC sources to treat early-stage OA in the perspective of Lysholm score, VAS Score, KSS score, and WOMAC score. Method Original articles from 2013 to 2023 were screened from four databases, focusing on clinical trials and randomized controlled trials. The Risk of Bias in Non-randomized Studies-of Interventions (ROB-2) tool evaluated bias, and a PICOS criteria table guided result construction. Revman 5.4 analyzed outcomes such as Lysholm score, VAS score, KSS, WOMAC score, cartilage volume, and defect size using MRI. This systematic review adhered to PRISMA guidelines. Result Nine studies met the final inclusion criteria. Meta-analysis revealed a significant improvement in Lysholm score (MD: 17.89; 95% CI: 16.01, 19.77; I2 = 0%, P = 0.56), a notable reduction in VAS score (MD: -2.62; 95% CI: -2.83, -2.41; I2 = 99%, P < 0.00001), elevated KSS (MD: 29.59; 95% CI: 27.66, 31.52; I2 = 95%, P < 0.0001), and reduced WOMAC score (MD: -12.38; 95% CI: -13.75, -11.01; I2 = 99%, P < 0.0001). Conclusions Arthroscopic guided high-dose subchondral application of primary cultured synovial MSCs in popliteal PRP media with HA effectively regenerates cartilage defects and improves clinical outcomes in early-stage osteoarthritis. Clarification of MSC sources and quantities enhances the understanding of this promising treatment modality. © 2024 Tjandra et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Humans; Hyaluronic Acid; Injections, Intra-Articular; Osteoarthritis, Knee; Platelet-Rich Plasma; Treatment Outcome; Viscosupplements; hyaluronic acid; viscosupplement; human; intraarticular drug administration; knee osteoarthritis; meta analysis; thrombocyte rich plasma; treatment outcome
Public Library of Science
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Article
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