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Publikasi Scopus 2024 per tanggal 31 Maret 2024 (233 artikel)
Publikasi Scopus 2024 per tanggal 31 Maret 2024 (233 artikel)
Sanchez, Karmele Llano (57200632467); Baird, J. Kevin (15921267800); Nielsen, Aileen (57221277141); Nurillah, Andini (57912908400); Agustina, Fitria (57912690600); Komara (58894822000); Fadilah, Fina (58895037400); Prameswari, Wendi (57191862252); Nugraha, R. Taufiq P. (58895694300); Saputra, Sugiyono (57076979100); Nurkanto, Arif (36025675800); Dharmayanthi, Anik Budhi (57193719895); Pratama, Rahadian (57222242146); Exploitasia, Indra (57300385400); Greenwood, Alex D. (7102457657)
Naturally Acquired Immunity to Plasmodium pitheci in Bornean Orangutans (Pongo pygmaeus)
2024
Parasitology
0
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85185520183&doi=10.1017%2fS0031182024000155&partnerID=40&md5=11f083d01fc6e6c6b92d74e29d0c876d
IAR Indonesia Foundation, Yayasan Inisiasi Alam Rehabilitasi Indonesia (YIARI), Sinarwangi, West Java, Bogor, Indonesia; International Animal Rescue, Uckfield, United Kingdom; Oxford University Clinical Research Unit-Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Center for Law and Economics, ETH Zurich, Zurich, Switzerland; Research Center for Applied Zoology, National Research and Innovation Agency, BRIN, Indonesia; Research Center for Biosystematics and Evolution, National Research and Innovation Agency, BRIN, Indonesia; Center for Biomedical Research, Research Organization for Health, National Research and Innovation Agency of Indonesia, Indonesia; Biodiv. Conserv. Directorate of the General Director of Natural Resources and Ecosystem Conservation, Ministry of Environment and Forestry, Indonesia; Department of Wildlife Diseases, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany; School of Veterinary Medicine, Frei Universität, Berlin, Germany
Naturally acquired immunity to the malarias of humans occurs in areas of endemic transmission and results in asymptomatic infection of peripheral blood. The current study examined the possibility of naturally acquired immunity in Bornean orangutans, Pongo pygmaeus, exposed to endemic Plasmodium pitheci malaria. A total of 2,140 peripheral blood samples were collected between January 2017 and December 2022 from a cohort of 135 orangutans housed at a natural forested Rescue and Rehabilitation Centre (RRC) in West Kalimantan, Indonesia. Each individual was observed for an average of 4.3 years during the study period. Blood samples were examined by microscopy and by PCR for the presence of plasmodial parasites. Infection rates and parasitaemia levels were measured among age groups and all 20 documented clinical malaria cases were reviewed to estimate the incidence of illness and risk ratios among age groups. A case group of all 17 individuals that had experienced clinical malaria and a control group of 34 individuals having an event of >2000 parasites/ μL blood but with no outward or clinical sign of illness were composed. Immature orangutans had higher-grade and more frequent parasitaemias, but mature individuals were more likely to suffer clinical malaria than juveniles. The case orangutans having patent clinical malaria were 256-times more likely to have had no parasitaemia event in the prior year relative to asymptomatic control orangutans. The findings are consistent with rapidly acquired immunity to P. pitheci illness among orangutans that wanes without re-exposure to the pathogen. © 2024 Cambridge University Press. All rights reserved.
Cambridge University Press
00311820
38361461
Article
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