Publikasi Scopus 2024 per tanggal 31 Maret 2024 (233 artikel)

Publikasi Scopus 2024 per tanggal 31 Maret 2024 (233 artikel)

Safri A.Y.; Harris S.; Haryono P.D.; Budiwan A.B.; Isadora E.; Prawiningrum A.F.; Fadilah F.
Safri, Ahmad Yanuar (57091699300); Harris, Salim (58332805200); Haryono, Putera Dewa (57223016376); Budiwan, Ariane Benina (58937602000); Isadora, Eugenia (58938030800); Prawiningrum, Aisyah Fitriannisa (57221924249); Fadilah, Fadilah (56966708600)
57091699300; 58332805200; 57223016376; 58937602000; 58938030800; 57221924249; 56966708600
Unveiling Potential Therapies: Molecular Docking Analysis of CAMKK2 and Its Mutant Variants with CAMKK2 Inhibitors in Indonesian Patients with HIV-Sensory Neuropathy
2024
Pharmacognosy Journal
16
1
46
51
5
0
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85187638559&doi=10.5530%2fpj.2024.16.7&partnerID=40&md5=4fdb98e47f6aad3029cefe76244eb9ca
Doctoral Program in Biomedical Sciences, Faculty of Medicine Universitas, Indonesia; Neurology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Neurology Department, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bioinformatics Core Facilities IMERI, Medical Chemistry Department, Indonesia; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia
Safri A.Y., Doctoral Program in Biomedical Sciences, Faculty of Medicine Universitas, Indonesia, Neurology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Neurology Department, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harris S., Neurology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Neurology Department, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Haryono P.D., Neurology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Neurology Department, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Budiwan A.B., Neurology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Neurology Department, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Isadora E., Neurology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Neurology Department, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prawiningrum A.F., Bioinformatics Core Facilities IMERI, Medical Chemistry Department, Indonesia; Fadilah F., Bioinformatics Core Facilities IMERI, Medical Chemistry Department, Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia
HIV sensory neuropathy (HIV-SN) is one among many complications that impair patients' quality of life. Studies in Asian and African populations found that single nucleotide polymorphisms (SNPs) of calcium/calmodulin-dependent protein kinase 2 (CAMKK2) influence the risk of HIV-SN. This study attempts to explain the influence of CAMKK2 mutations on HIV SN by studying bioinformatics interactions between CAMKK2, its mutants, and their inhibitors by molecular docking with AutoDock in order to observe their interactions with CAMKK2 inhibitors. Results showed that CAMKK2's binding energy with its native ligand (ATP) is stronger than the mutant variant of CAMKK2MT85 and CAMKK2MT363. Conversely, interaction between CAMKK2 and its inhibitors (KN-93, STO-609, and trifluoperazine) have the lowest mean binding energy compared to CAMKK2MT85 and CAMKK2MT363. This indicates that the mutant variants have weaker interactions with the native ligand and the inhibitors, therefore disrupting the normal function of CAMKK2, its interactions with the inhibitors, while increasing the likelihood of HIV-SN. © 2024 Phcogj.Com.
CAMKK2 inhibitors; HIV-SN; molecular docking; mutation; SNP
EManuscript Technologies
09753575
Article
Q3
229
17759

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