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Publikasi Scopus 2024 per tanggal 31 Maret 2024 (233 artikel)
Publikasi Scopus 2024 per tanggal 31 Maret 2024 (233 artikel)
Bachtiar, Endang (6507328763); Bachtiar, Boy M (15831189400); Kusumaningrum, Ardiana (57211641695); Sunarto, Hari (56538916200); Soeroso, Yuniarti (56589126400); Sulijaya, Benso (57190752315); Apriyanti, Efa (57201498107); Theodorea, Citra Fragrantia (57190048861); Putra Pratomo, Irandi (58853138600); Yudhistira, Yudhistira (57193497388); Efendi, Defi (57201494445); Lestari, Widya (54880290000)
The utility of salivary CRP and IL-6 as a non-invasive measurement evaluated in patients with COVID-19 with and without diabetes
2024
F1000Research
12
419
0
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183576452&doi=10.12688%2ff1000research.130995.3&partnerID=40&md5=ed9ba08e0313c4fb74ba91223daf1fe0
Department of Oral Biology and Oral Sciences Research Center, Faculty of Dentistry Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Clinical Microbiology Medicine Staff Group, Universitas Indonesia Hospital, Jakarta, 10430, Indonesia; Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Dental Center, Universitas Indonesia Hospital, West Java, Depok, Indonesia; Department of Pediatric Nursing, Faculty of Nursing Universitas Indonesia, Paediatric Intensive Care Unit, Universitas Indonesia Hospital, West Java, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Clinical Pathology Medicine Staff Group, Universitas Indonesia Hospital, West Java, Depok, Indonesia; Department of Pediatric Nursing, Faculty of Nursing Universitas Indonesia, Neonatal Intensive Care Unit, Universitas Indonesia Hospital, West Java, Depok, Indonesia; Oral Biology Unit, Fundamental Dental and Medical Sciences Kuala Lumpur, Malaysia International Islamic University Malaysia, Kuala Lumpur, Malaysia
Background: The available evidence suggests that inflammatory responses, in both systemic and oral tissue, contribute to the pathology of COVID-19 disease. Hence, studies of inflammation biomarkers in oral fluids, such as saliva, might be useful to better specify COVID-19 features. Methods: In the current study, we performed quantitative real-time PCR to measure salivary levels of C-reactive protein (CRP) and interleukin-6 (IL-6) in saliva obtained from patients diagnosed with mild COVID-19, in a diabetic group (DG; n = 10) and a non-diabetic group (NDG; n = 13). All participants were diagnosed with periodontitis, while six participants with periodontitis but not diagnosed with COVID-19 were included as controls. Results: We found increases in salivary total protein levels in both the DG and NDG compared to control patients. In both groups, salivary CRP and IL-6 levels were comparable. Additionally, the levels of salivary CRP were significantly correlated with total proteins, in which a strong and moderate positive correlation was found between DG and NDG, respectively. A linear positive correlation was also noted in the relationship between salivary IL-6 level and total proteins, but the correlation was not significant. Interestingly, the association between salivary CRP and IL-6 levels was positive. However, a moderately significant correlation was only found in COVID-19 patients with diabetes, through which the association was validated by a receiver operating curve. Conclusions: These finding suggest that salivary CRP and IL-6 are particularly relevant as potential non-invasive biomarker for predicting diabetes risk in mild cases of COVID-19 accompanied with periodontitis. Copyright: © 2024 Bachtiar E et al.
C-Reactive Protein; COVID-19; Diabetes Mellitus; Humans; Interleukin-6; Periodontitis; biological marker; C reactive protein; interleukin 6; C reactive protein; interleukin 6; adult; aged; area under the curve; Article; controlled study; coronavirus disease 2019; correlation analysis; diabetes mellitus; diagnostic test accuracy study; female; human; major clinical study; male; middle aged; mouth tissue; non invasive measurement; periodontitis; protein expression; quantitative analysis; real time polymerase chain reaction; receiver operating characteristic; saliva; saliva level; validation process; complication; diabetes mellitus; periodontitis
Universitas Indonesia, UI, (NKB-1126 /UN2.RST/HKP.05.00/2022)
This study was supported by Universitas Indonesia (Grant NKB-1126 /UN2.RST/HKP.05.00/2022).
F1000 Research Ltd
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Article
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