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Publikasi Scopus 2024 per tanggal 31 Mei 2024 (409 artikel)
Publikasi Scopus 2024 per tanggal 31 Mei 2024 (409 artikel)
Sinto, Robert (36099377100); Lie, Khie Chen (56606750200); Setiati, Siti (14325991900); Suwarto, Suhendro (8443626100); Nelwan, Erni J. (14527452900); Karyanti, Mulya Rahma (56290680800); Karuniawati, Anis (54886816200); Djumaryo, Dean Handimulya (57700320800); Prayitno, Ari (57193342301); Sumariyono, Sumariyono (57477855200); Sharland, Mike (57203106412); Moore, Catrin E. (57195934063); Hamers, Raph L. (23034345900); Day, Nicholas P.J. (57708887000); Limmathurotsakul, Direk (57220064094)
Diagnostic and antibiotic use practices among COVID-19 and non-COVID-19 patients in the Indonesian National Referral Hospital
2024
PLoS ONE
19
3 March
e0297405
0
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85187184049&doi=10.1371%2fjournal.pone.0297405&partnerID=40&md5=82732bc6ff982a973a8fc76e682787d7
Division of Tropical and Infectious Diseases, Department of Internal Medicine, Cipto Mangunkusumo National Hospital, Faculty of Medicine Universitas Indonesia, Jakarta Pusat, Jakarta, Indonesia; Infection and Antimicrobial Resistance Control Committee, Cipto Mangunkusumo National Hospital, Jakarta Pusat, Jakarta, Indonesia; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Department of Internal Medicine, Cipto Mangunkusumo National Hospital, Faculty of Medicine Universitas Indonesia, Jakarta Pusat, Jakarta, Indonesia; Center for Clinical Epidemiology and Evidence Based Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta Pusat, Jakarta, Indonesia; Department of Child Health, Cipto Mangunkusumo National Hospital, Faculty of Medicine Universitas Indonesia, Jakarta Pusat, Jakarta, Indonesia; Department of Clinical Microbiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta Pusat, Jakarta, Indonesia; Department of Clinical Pathology, Cipto Mangunkusumo National Hospital, Faculty of Medicine Universitas Indonesia, Jakarta Pusat, Jakarta, Indonesia; Board of Directors, Cipto Mangunkusumo National Hospital, Jakarta Pusat, Jakarta, Indonesia; Centre for Neonatal and Paediatric Infection, St George’s University of London, Cranmer Terrace, London, United Kingdom; Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta Pusat, Jakarta, Indonesia; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Background Little is known about diagnostic and antibiotic use practices in low and middle-income countries (LMICs) before and during COVID-19 pandemic. This information is crucial for monitoring and evaluation of diagnostic and antimicrobial stewardships in healthcare facilities. Methods We linked and analyzed routine databases of hospital admission, microbiology laboratory and drug dispensing of Indonesian National Referral Hospital from 2019 to 2020. Patients were classified as COVID-19 cases if their SARS-CoV-2 RT-PCR result were positive. Blood culture (BC) practices and time to discontinuation of parenteral antibiotics among inpatients who received a parenteral antibiotic for at least four consecutive days were used to assess diagnostic and antibiotic use practices, respectively. Fine and Grey subdistribution hazard model was used. Results Of 1,311 COVID-19 and 58,917 non-COVID-19 inpatients, 333 (25.4%) and 18,837 (32.0%) received a parenteral antibiotic for at least four consecutive days. Proportion of patients having BC taken within ±1 calendar day of parenteral antibiotics being started was higher in COVID-19 than in non-COVID-19 patients (21.0% [70/333] vs. 18.7% [3,529/18,837]; p<0.001). Cumulative incidence of having a BC taken within 28 days was higher in COVID-19 than in non-COVID-19 patients (44.7% [149/333] vs. 33.2% [6,254/18,837]; adjusted subdistribution-hazard ratio [aSHR] 1.71, 95% confidence interval [CI] 1.47–1.99, p<0.001). The median time to discontinuation of parenteral antibiotics was longer in COVID-19 than in non-COVID-19 patients (13 days vs. 8 days; aSHR 0.73, 95%Cl 0.65–0.83, p<0.001). Conclusions Routine electronic data could be used to inform diagnostic and antibiotic use practices in LMICs. In Indonesia, the proportion of timely blood culture is low in both COVID-19 and nonCOVID-19 patients, and duration of parenteral antibiotics is longer in COVID-19 patients. Improving diagnostic and antimicrobial stewardship is critically needed. © 2024 Sinto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Anti-Bacterial Agents; COVID-19; COVID-19 Testing; Hospitals; Humans; Indonesia; Pandemics; SARS-CoV-2; antibiotic agent; antiinfective agent; adolescent; adult; aged; antibiotic use practices; antimicrobial stewardship; Article; blood culture; child; coronavirus disease 2019; cumulative incidence; diagnostic practices; drug use; female; hospital admission; human; infant; longitudinal study; male; medical practice; methicillin resistant Staphylococcus aureus; middle aged; mortality; newborn; retrospective study; reverse transcription polymerase chain reaction; Severe acute respiratory syndrome coronavirus 2; coronavirus disease 2019; COVID-19 testing; hospital; Indonesia; pandemic
Cipto Mangunkusumo National Hospital; Division of Tropical and Infectious Diseases; Indonesian Endowment Fund for Education; Ministry of Education, Culture, Research, and Technology Republic of Indonesia: Directorate General of Higher Education, Research, and Technology; Wellcome Trust, WT, (202101182688, 220211); Wellcome Trust, WT; Department of Internal Medicine, University of Utah; Lembaga Pengelola Dana Pendidikan, LPDP
This study is funded by Research Fund of Division of Tropical and Infectious Diseases, Department of Internal Medicine, Cipto Mangunkusumo National Hospital and in part by the Wellcome Trust [220211]. RS is funded by Indonesian Education Scholarship (Beasiswa Pendidikan Indonesia [BPI]) [202101182688] from the Ministry of Education, Culture, Research, and Technology Republic of Indonesia: Director
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