Publikasi Scopus 2024 per tanggal 31 Mei 2024 (409 artikel)

202

Authors

Kartika I.R.; Nurjayadi M.; Dianhar H.; Kurniadewi F.; Ernawati T.; Lotulung P.D.N.; Sadikin M.; Jusman S.W.A.

Author_Full_Names

Kartika, Irma Ratna (57190936521); Nurjayadi, Muktiningsih (57190936791); Dianhar, Hanhan (56242806300); Kurniadewi, Fera (39862994300); Ernawati, Teni (56584718700); Lotulung, Puspa Dewi N. (25925896400); Sadikin, Mohamad (36981411100); Jusman, Sri Widia A. (36518792100)

Author S Id

57190936521; 57190936791; 56242806300; 39862994300; 56584718700; 25925896400; 36981411100; 36518792100

Title

Simulation of Vitamin C Derivatives as Antioxidant Using Molecular Docking

Year

2024

Source Title

AIP Conference Proceedings

Volume

2982

Issue

Art No

040024

Page Start

Page End

Page Count

Cited By

Link

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183303202&doi=10.1063%2f5.0183016&partnerID=40&md5=3d170d38a64e3dc6f4be07e4d7b7802b

Affiliations

Chemistry Undergraduate Program, FMIPA, UNJ, Jakarta, 13220, Indonesia; Research Center for Pharmaceutical Ingredients and Traditional Medicine, The National Research and Innovation Agency of Indonesia (BRIN), Banten, Tangerang Selatan, 15314, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia

Authors With Affiliations

Kartika I.R., Chemistry Undergraduate Program, FMIPA, UNJ, Jakarta, 13220, Indonesia; Nurjayadi M., Chemistry Undergraduate Program, FMIPA, UNJ, Jakarta, 13220, Indonesia; Dianhar H., Chemistry Undergraduate Program, FMIPA, UNJ, Jakarta, 13220, Indonesia; Kurniadewi F., Chemistry Undergraduate Program, FMIPA, UNJ, Jakarta, 13220, Indonesia; Ernawati T., Research Center for Pharmaceutical Ingredients and Traditional Medicine, The National Research and Innovation Agency of Indonesia (BRIN), Banten, Tangerang Selatan, 15314, Indonesia; Lotulung P.D.N., Research Center for Pharmaceutical Ingredients and Traditional Medicine, The National Research and Innovation Agency of Indonesia (BRIN), Banten, Tangerang Selatan, 15314, Indonesia; Sadikin M., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Jusman S.W.A., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia

Abstract

Vitamin C (ascorbic acid) plays an exogenous antioxidant to protect biomolecules against cellular redox-reactive species generation, including ROS, that is involved in the development of oxidative stress-related diseases. Therefore, some ascorbic acid studies have concentrated on its ROS scavenging activity. We designed a combination of vitamin C and octanoic acid as vitamin C derivatives to evaluate their antioxidant potential in silico study using molecular docking. Compound 1 demonstrated the receptor-ligand interaction in Lipoxygenase (LO) than Zileuton-ZIL with its lower binding free energy (ΔG) and inhibition constant (Ki) value. Meanwhile, 6 exhibited lower Gibs energy (ΔG) and inhibition constant (Ki) in NADPH oxidase (NO) receptor than Dextromethorphan-DEX. The results add to the evidence supporting antioxidant activities of 1 and 6 in two receptors (LO and NO, respectively) via ROS generation. Thus, further research is warranted into their efficiency in reducing oxidative stress for possible commercial antioxidants. © 2024 American Institute of Physics Inc.. All rights reserved.

Author Keywords

Index Keywords

Funding Details

Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Negeri Jakarta, FMIPA, UNJ, (407/UN39//HK.02/2022)

Funding Text

The authors received financial support from Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Jakarta, grant number: 407/UN39//HK.02/2022.

Publisher

American Institute of Physics Inc.

Issn

0094243X

Isbn

978-073544801-8

Pubmed Id

Document Type

Conference paper

Sjr Best Quartile

Sjr

164

Sjr Rank

21059