Publikasi Scopus 2024 per tanggal 31 Mei 2024 (409 artikel)

225

Authors

Yani S.; Harris S.; Jusuf A.A.; Goenarjo R.; Makkiyah F.A.; Sabita R.; Ibrahim N.

Author_Full_Names

Yani, Sri (58694779600); Harris, Salim (55325116600); Jusuf, Ahmad Aulia (57192275719); Goenarjo, Roman (57192916469); Makkiyah, Feda Anisah (57210232162); Sabita, Rifqi (59132702300); Ibrahim, Nurhadi (56609777400)

Author S Id

58694779600; 55325116600; 57192275719; 57192916469; 57210232162; 59132702300; 56609777400

Title

Effect of the High-Intensity Interval Training on BDNF Level in Ischemic Stroke Rat Model on the Recovery of Motor Function

Year

2024

Source Title

Indonesian Biomedical Journal

Volume

Issue

Art No

Page Start

152

Page End

161

Page Count

Cited By

Link

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193499298&doi=10.18585%2finabj.v16i2.2911&partnerID=40&md5=52dbaa3bbdf912eed4f7ed0a3f4bb299

Affiliations

Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Physiotherapy Study Programme, Faculty of Health Science, Universitas Pembangunan Nasional Veteran Jakarta, Jl. RS Fatmawati Pondok Labu, Jakarta, 12450, Indonesia; Division of Neurovascular-Neurosonology-Neurointervention, Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Neuroscience Cluster Research Unit, Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jl. RS Fatmawati Pondok Labu, Jakarta, 12450, Indonesia; Magister Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Neurosciences and Brain Development Cluster, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia

Authors With Affiliations

Yani S., Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia, Physiotherapy Study Programme, Faculty of Health Science, Universitas Pembangunan Nasional Veteran Jakarta, Jl. RS Fatmawati Pondok Labu, Jakarta, 12450, Indonesia; Harris S., Division of Neurovascular-Neurosonology-Neurointervention, Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Jusuf A.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Goenarjo R., Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Makkiyah F.A., Neuroscience Cluster Research Unit, Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jl. RS Fatmawati Pondok Labu, Jakarta, 12450, Indonesia; Sabita R., Magister Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Ibrahim N., Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia, Neurosciences and Brain Development Cluster, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia

Abstract

BACKGROUND: Stroke is one of the major causes of disability in the world. High-intensity interval training (HIIT) is known as a novel treatment to promote stroke recovery. However, the results differ in their effects on irisin, which is a regulator of brain-delivered neurotrophic factor (BDNF). Therefore, this study was conducted to investigate the effect of HIIT on BDNF and irisin levels in a rat model of ischemic stroke with middle cerebral artery occlusion (MCAO) induction on recovery motor function. METHODS: Rats were categorized into 4 groups: sham, MCAO, MCAO+moderate-intensity interval training (MIIT), and MCAO+HIIT. MCAO induction was performed to create the ischemic stroke rats model. The motor function was assessed through rotarod and footprint tests. Blood samples were obtained 6 days before MCAO and 14 days after MCAO to examine BDNF and irisin levels with enzyme-linked immunosorbent assay (ELISA). Brain tissue samples were collected 14 days after MCAO for histopathological examination of cortical tissue with hematoxylin-eosin (HE) staining. RESULTS: Rats in the MCAO+HIIT group exhibited an enhanced ability to walk on the rotarod (p=0.016). The stride-length hind paw right in the MCAO+HIIT group demonstrated a noteworthy increase in comparison to baseline value (p=0.036), and the stride-length fore paw right showed a significant increase in both the MCAO+HIIT (p=0.036) and MCAO groups (p=0.034). BDNF significantly improved in the MCAO+MIIT (p=0.043) and MCAO+HIIT groups (p=0.018). The irisin level only showed a significant enhancement in the MCAO+HIIT group (p=0.018). CONCLUSION: HIIT increased motor function, while BDNF level increased with HIIT and MIIT intervention. This preclinical research is useful for supporting the recovery of stroke patients by HIIT intervention. © 2024 The Prodia Education and Research Institute. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC-BY-NC) License. All Rights Reserved.

Author Keywords

BDNF; HIIT; irisin; ischemic stroke; MCAO; MIIT

Index Keywords

Funding Details

Lembaga Pengelola Dana Pendidikan, LPDP; Anatomy Department of the Faculty of Medicine, Universitas Indonesia

Funding Text

The author would also like to thank Lembaga Pengelola Dana Pendidikan (LPDP) for funding this research, as well as Animal Research Facilities of Indonesia Medical Education and Research Institute (ARF IMERI), Integrated Laboratory and Research Centre, Histology Department, Physiology Department, and Anatomy Department of the Faculty of Medicine, Universitas Indonesia for the facilities.

Publisher

Prodia Education and Research Institute

Issn

20853297

Isbn

Pubmed Id

Document Type

Article

Sjr Best Quartile

Sjr

218

Sjr Rank

18286