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Publikasi Scopus 2024 per tanggal 31 Mei 2024 (409 artikel)
Publikasi Scopus 2024 per tanggal 31 Mei 2024 (409 artikel)
Harsono, Anastasia Dessy (57720834600); Dilogo, Ismail Hadisoebroto (56161962800); Prasetyono, Theddeus Octavianus Hari (26646993900); Prasetyo, Marcel (57192905252); Werdhani, Retno Asti (57189088848); Jusman, Sri Widia A. (36518792100); Siregar, Nuryati Chairani (6508087790); Soedjana, Hardisiswo (35318899300)
Clinical evaluation of intralesional umbilical cord-derived mesenchymal stem cells, conditioned medium and triamcinolone acetonide injection for keloid treatment: A pilot study
2024
International Wound Journal
21
2
e14460
1
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85175012018&doi=10.1111%2fiwj.14460&partnerID=40&md5=85cfd6ad423e1336a3477510ccd63470
Department of Plastic and Reconstructive Surgery, Gatot Subroto Army Hospital, Jakarta, Indonesia; Doctoral Program in Medical Sciences Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; ICTEC (Indonesian Clinical Training and Education Center), Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Medical Technology Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell and Tissue Engineering Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Orthopaedic and Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Plastic and Reconstructive Surgery, Department of Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Radiology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Community Medicine, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomical Pathology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Plastic and Reconstructive Surgery, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia
Topical keloid therapy is performed with triamcinolone acetonide (TA) intralesional injection. However, the recurrence rate is high with various side effects. Mesenchymal stem cells (MSCs) have high proliferative abilities and reduce the activity and proliferation of fibroblast cells in keloids. To overcome the costs and limitations, conditioned medium (CM) is used. This study aims to evaluate feasibility of intralesional injection of umbilical cord MSC (UC-MSC) and conditioned medium (UC-CM) compared to TA for keloid therapy. Twenty-four patients with keloids who met the inclusion criteria were included, randomized into three treatment groups and then got assessed for the sociodemographic data, keloid volume, histopathology (type 1:3 collagen ratio), interleukin-10 (IL-10) levels and Patient and Observer Scar Assessment Scale (POSAS) score during visits. Largest volume regression occurred in the UC-MSC group, followed by UC-CM and then the TA group (UC-MSC: 45.32% ± 2.61%; UC-CM: 43.61% ± 3.67%; TA: 28.34% ± 3.81%; p = 0.003). Similar pattern was also observed in increase in IL-10 levels, the decrease in POSAS scores and the reduction of type 1:3 collagen ratio. Hence, UC-MSC and UC-CM are promisingly more effective than TA for keloid therapy, showcasing their superiority in reducing keloid volume, symptoms and type 1:3 collagen ratio, as well as increasing the levels of IL-10. © 2023 The Authors. International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd.
collagen; interleukin 10; triamcinolone acetonide; adult; Article; clinical article; clinical effectiveness; clinical evaluation; collagen ratio; controlled study; cutaneous parameters; double blind procedure; feasibility study; female; human; human tissue; in vitro study; intermethod comparison; keloid; male; Patient and Observer Scar Assessment Scale; pilot study; protein expression; punch biopsy; randomized controlled trial; skin disease assessment; sociodemographics; umbilical cord mesenchymal stem cell
Cipto Mangunkusumo Hospital; Direktorat Riset and Pengembangan, Universitas Indonesia, DRPM UI; Fakultas Kedokteran, Universitas Indonesia, FKUI
Funding text 1: The authors would like to express highest gratitude to the Directorate of Research and Development Universitas Indonesia for the research grant. Special thanks go to Plastic Surgery Outpatient Clinic at Gatot Soebroto Army Hospital and Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia.; Funding text 2: The
John Wiley and Sons Inc
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