Publikasi Scopus 2024 per tanggal 31 Mei 2024 (409 artikel)

238

Authors

Hestiantoro A.; Saraswati J.; Prasetya D.E.; Sandra F.; Muharam R.; Pratama G.; Harzif A.K.

Author_Full_Names

Hestiantoro, Andon (8743255100); Saraswati, Jaya (59072893900); Prasetya, David Eka (57218392021); Sandra, Ferry (56016164200); Muharam, Raden (57191492732); Pratama, Gita (58162878900); Harzif, Achmad Kemal (57191493435)

Author S Id

8743255100; 59072893900; 57218392021; 56016164200; 57191492732; 58162878900; 57191493435

Title

Triglyceride-Glucose Index as A Crucial Marker for Polycystic Ovary Syndrome Women with Insulin Resistance

Year

2024

Source Title

Indonesian Biomedical Journal

Volume

Issue

Art No

Page Start

Page End

Page Count

Cited By

Link

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85192503057&doi=10.18585%2finabj.v16i1.2639&partnerID=40&md5=54989f651c7699e8e88a4e77ef3213b7

Affiliations

Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo General Hospital, Jl, Salemba Raya No.6, Jakarta, 10430, Indonesia; Human Reproduction Infertility, Family Planning Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Department of Biochemistry and Molecular Biology, Division of Oral Biology, Faculty of Dentistry, Universitas Trisakti, Jl. Kyai Tapa No. 260, Jakarta, 11440, Indonesia

Authors With Affiliations

Hestiantoro A., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo General Hospital, Jl, Salemba Raya No.6, Jakarta, 10430, Indonesia, Human Reproduction Infertility, Family Planning Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Saraswati J., Human Reproduction Infertility, Family Planning Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Prasetya D.E., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo General Hospital, Jl, Salemba Raya No.6, Jakarta, 10430, Indonesia; Sandra F., Department of Biochemistry and Molecular Biology, Division of Oral Biology, Faculty of Dentistry, Universitas Trisakti, Jl. Kyai Tapa No. 260, Jakarta, 11440, Indonesia; Muharam R., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo General Hospital, Jl, Salemba Raya No.6, Jakarta, 10430, Indonesia, Human Reproduction Infertility, Family Planning Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Pratama G., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo General Hospital, Jl, Salemba Raya No.6, Jakarta, 10430, Indonesia, Human Reproduction Infertility, Family Planning Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Harzif A.K., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo General Hospital, Jl, Salemba Raya No.6, Jakarta, 10430, Indonesia, Human Reproduction Infertility, Family Planning Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia

Abstract

BACKGROUND: Insulin resistance (IR) is considered as the main driver of polycystic ovary syndrome (PCOS) pathogenesis. In PCOS condition, IR is frequently related to glucose, anthropometric profile, lipid profile, and hormone profile parameters. However, not all PCOS phenotype show IR. Therefore, this study was conducted to determine the association the parameters mentioned above in PCOS subjects with and without IR. METHODS: Fifty PCOS women with IR and 26 PCOS women without IR were recruited. All subjects underwent physical examination for measurement of weight, waist circumference (WC), and body mass index (BMI). Ferriman Gallwey Score (FGS) was used to evaluate hirsutism. Blood sample was taken from each subject for measurement of fasting glucose, postprandial glucose, fasting insulin, low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol, triglyceride (TG), sex hormone binding globulin (SHBG), thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle stimulating hormone (FSH), and prolactin. Homeostatic model assessment for IR (HOMA-IR), TG-glucose index (TyGI), and free testosterone index (FTI) were then calculated. RESULTS: From all the parameters examined, only fasting insulin (p<0.001), HOMA-IR (p<0.001), SHBG (p=0.012), TG (p<0.001), and TyGI (p=0.008) that show significant differences between PCOS subjects with and without IR. After multivariate analysis, TyGI was found to have strong association with IR occurrence in PCOS subjects (p=0.005) with an odd ratio of 5.26 (1.65–16.74). CONCLUSION: TyGI appears to have a significant association with the IR occurrence in PCOS subjects. Hence, it can be suggested that TyGI could be an important marker for PCOS women with IR. © (2024) The Prodia Education and Research Institute.

Author Keywords

insulin resistance; lipid metabolism; polycystic ovary syndrome; triglyceride-glucose index

Index Keywords

Funding Details

Indonesian Medical Education and Research Institute; Fakultas Kedokteran, Universitas Indonesia, FKUI; Prodia Education and Research Institute; Prodia Clinical Laboratory Great Regional Jakarta

Funding Text

We thank Naylah Munaf, Kresna Mutia, Ririn Rahmala Febri, Pritta Ameilia, Oki Riayati for collecting, organising laboratory samples and conducting statistical analysis at the Human Reproduction, Infertility, and Family Planning cluster of the Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia. The authors would like to thank the Prodia Education

Publisher

Prodia Education and Research Institute

Issn

20853297

Isbn

Pubmed Id

Document Type

Article

Sjr Best Quartile

Sjr

218

Sjr Rank

18286