- +62 21 29189160 (ext. 201912)
- manajer.riset.fkui1@gmail.com
- Senin-Jum'at 8.00 s/d 16.00 WIB
Publikasi Scopus 2024 per tanggal 31 Mei 2024 (409 artikel)
Publikasi Scopus 2024 per tanggal 31 Mei 2024 (409 artikel)
Bachtiar, Endang W. (6507328763); Bachtiar, Boy M. (15831189400); Kusumaningrum, Ardiana (57211641695); Sunarto, Hari (57219511605); Soeroso, Yuniarti (56589126400); Sulijaya, Benso (57190752315); Theodorea, Citra Fragrantia (57190048861); Pratomo, Irandi Putra (57192904477); Yudhistira (57666445700); Efendi, Defi (57201494445); Apriyanti, Efa (57201498107); Said, Shahida Mohd (57194239233)
Association between dysbiotic perio-pathogens and inflammatory initiators and mediators in COVID-19 patients with diabetes
2024
Heliyon
10
2
e24089
0
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85181843391&doi=10.1016%2fj.heliyon.2024.e24089&partnerID=40&md5=ecda0d95e64de258d6f7622917b40ccd
Department of Oral Biology, Faculty of Dentistry Universitas Indonesia, Indonesia; Oral Science Research Center, Faculty of Dentistry Universitas Indonesia, Indonesia; Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Clinical Microbiology Medicine Staff Group, Universitas Indonesia Hospital, Indonesia; Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Indonesia; Dental Center Universitas Indonesia Hospital, Depok, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Pulmonology and Respiratory Medicine Staff Group - COVID-19 Task Force, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia; Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Indonesia; Clinical Pathology Medicine Staff Group, Universitas Indonesia Hospital, Indonesia; Department of Pediatric Nursing, Faculty of Nursing Universitas Indonesia, and Neonatal Intensive Care Unit, Universitas Indonesia Hospital, Depok, Indonesia; Department of Pediatric Nursing, Faculty of Nursing Universitas Indonesia, and Paediatric Intensive Care Unit, Universitas Indonesia Hospital, Indonesia; Department of Restorative Dentistry, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur, 50300, Malaysia
It has been suggested that a corona virus infection is linked to chronic periodontitis (COVID-19). Our objectives were to look at the expression of angiotensin-converting enzyme-2 (ACE2) in periodontal compartments containing periodontal infections to determine if ACE2 is directly or indirectly responsible for the inflammation in periodontal tissues getting worse. In this study, six non-COVID-19 periodontitis patients without diabetes served as controls, and 23 hospitalized periodontitis patients were admitted with PCR-confirmed COVID-19 with diabetes mellitus (Group 1/G1, n = 10), and without diabetes (Group 2/G2, n = 13). We evaluated the mRNA expression of ACE2, IL-6, IL-8, complement C3, and LL-37, as well as the relative proportion of Porphyromonas gingivalis, Fusobacterium nucleatum, and Veillonella parvula to represent the dysbiosis condition in periodontal microenvironment using subgingival plaque and gingival crevicular fluids (GCF) samples and quantitative real time PCR (qPCR). Every analysis was done to ascertain how they related to one another. The area under the curve (AUC) and receiver operating characteristic (ROC) curve were used to determine the sensitivity and specificity of inflammatory indicators. All the grouped patients had ACE2 detected, according to our findings, but only the G1 patients had a positive correlation (p < 0.05) between ACE2 expression and the inflammatory markers. The combination of IL-6 and C3 mRNAs was found to be 0.78 and 0.55 for the G1 group and the G2 group, respectively, based on the ROC and AUC values. According to our research, the relationship between complement C3 and IL-6 may be able to predict the degree of periodontal inflammation in COVID-19 patients who also have diabetes. © 2024
Faculty of Dentistry Universitas Indonesia; Jakarta Indonesia; Oral Science Research Centre; RSUI; Universitas Indonesia Hospital; Universitas Indonesia, UI, (NKB-449/UN2, RST/HKP.05.00/2022); Universitas Indonesia, UI
The data that support the findings of this study are available from the Oral Science Research Centre, Faculty of Dentistry Universitas Indonesia, Jakarta Indonesia. Data are available from the corresponding authors upon reasonable request and permission of Dental Centre Universitas Indonesia Hospital.The director of Universitas Indonesia Hospital (RSUI), the ethical clearance committee, and all st
Elsevier Ltd
24058440
Article
Q1
609
8422
© 2024 Riset & Pengabdian Masyarakat. All Rights Reserved.