Publikasi Scopus 2024 per tanggal 31 Mei 2024 (409 artikel)

300

Authors

Dwimartutie N.; Setiati S.; Tamin T.Z.; Prijanti A.R.; Harahap A.R.; Purnamasari D.; Harimurti K.; Pramantara I.D.P.; Suwarto S.; Kojima T.

Author_Full_Names

Dwimartutie, Noto (37067234900); Setiati, Siti (14325991900); Tamin, Tirza Z. (23476060900); Prijanti, Ani Retno (57190863386); Harahap, Alida R. (6507325543); Purnamasari, Dyah (36519537700); Harimurti, Kuntjoro (23473513200); Pramantara, I Dewa Putu (36114863100); Suwarto, Suhendro (8443626100); Kojima, Taro (59105972300)

Author S Id

37067234900; 14325991900; 23476060900; 57190863386; 6507325543; 36519537700; 23473513200; 36114863100; 8443626100; 59105972300

Title

Effect of cholecalciferol supplementation on hand grip strength, walking speed, and expression of vitamin D receptor, interleukin-6, and insulin-like growth factor-1 in monocyte in pre-frail older adults: A randomized double-blind placebo-controlled trial

Year

2024

Source Title

Geriatrics and Gerontology International

Volume

Issue

Art No

Page Start

Page End

Page Count

Cited By

Link

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191158590&doi=10.1111%2fggi.14881&partnerID=40&md5=f89e3616758216e2b06bc06c9d973e68

Affiliations

Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Doctoral Program in Medical Sciences, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Musculoskeletal Rehabilitation, Department of Physical Medicine and Rehabilitation, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Endocrine and Metabolic, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Sardjito Hospital, Yogyakarta, Indonesia; Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Authors With Affiliations

Dwimartutie N., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Doctoral Program in Medical Sciences, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Setiati S., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Tamin T.Z., Division of Musculoskeletal Rehabilitation, Department of Physical Medicine and Rehabilitation, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Prijanti A.R., Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Harahap A.R., Doctoral Program in Medical Sciences, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Purnamasari D., Division of Endocrine and Metabolic, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Harimurti K., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pramantara I.D.P., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Sardjito Hospital, Yogyakarta, Indonesia; Suwarto S., Doctoral Program in Medical Sciences, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Kojima T., Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Abstract

Aim: To investigate the effect of cholecalciferol supplementation on hand grip strength, walking speed, and expression of vitamin D receptor (VDR), interleukine-6 (IL-6) and insulin-like growth factor-1 (IGF-1) in monocyte in pre-frail older adults. Methods: We conducted a randomized double-blinded placebo-controlled clinical trial for 12 weeks, involving 120 pre-frail older adults who were randomized to the cholecalciferol group (cholecalciferol 4000 IU/day) or the placebo group. All subjects were given calcium lactate 500 mg/day. Hand grip strength and walking speed, as primary outcomes, were analyzed using intention-to-treat analysis. The expression of VDR, IGF-1 and IL-6 in monocytes, as secondary outcomes, were analyzed using per-protocol analysis. Results: After a 12-week intervention, there was a significant increase in serum 25(OH)D levels in both groups, with the increase being higher in the cholecalciferol group than in the placebo group (49.05 vs. 24.01 ng/mL; P < 0.001). No statistically significant differences were observed in hand grip strength (P = 0.228) and walking speed (P = 0.734) between the groups. There were no differences in the expression of VDR (P = 0.513), IL-6 (P = 0.509), and IGF-1 (P = 0.503) monocytes between the groups. Conclusions: Cholecalciferol supplementation for 12 weeks increased serum 25(OH)D levels among pre-frail older adults. However, it did not improve hand grip strength and walking speed, and nor did it change the expression of VDR, IL-6, and IGF-1 in monocytes. Geriatr Gerontol Int 2024; ••: ••–••. © 2024 Japan Geriatrics Society.

Author Keywords

cholecalciferol; hand grip strength; monocytes; pre-frail older adult; walking speed

Index Keywords

Funding Details

Direktorat Riset and Pengembangan, Universitas Indonesia, DRPM UI, (NKB‐1255/UN2.RST/HKP.05.00/2022); Direktorat Riset and Pengembangan, Universitas Indonesia, DRPM UI

Funding Text

This research is funded by the Directorate of Research and Development, Universitas Indonesia under Hibah Publikasi Terindeks Internasional (PUTI) 2022 (NKB\u20101255/UN2.RST/HKP.05.00/2022). The funder had no role in the study design, data collection, data analysis, data interpretation, or writing of the report.

Publisher

John Wiley and Sons Inc

Issn

14441586

Isbn

Pubmed Id

38644647

Document Type

Article

Sjr Best Quartile

Sjr

771

Sjr Rank

6290