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Publikasi Scopus 2024 per tanggal 31 Mei 2024 (409 artikel)
Publikasi Scopus 2024 per tanggal 31 Mei 2024 (409 artikel)
Limardi, Prisca C. (57550819400); Panigoro, Sonar Soni (56790104300); Siregar, Nurjati Chairani (6508087790); Sutandyo, Noorwati (26028099200); Witjaksono, Fiastuti (57070455800); Priliani, Lidwina (57203360168); Oktavianthi, Sukma (38361976900); Malik, Safarina G. (7402973374)
Higher peripheral blood mitochondrial DNA copy number and relative telomere length in under 48 years Indonesian breast cancer patients
2024
BMC Research Notes
17
1
120
0
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191685269&doi=10.1186%2fs13104-024-06783-y&partnerID=40&md5=5f5744f23388d9f60271cd150d091085
Master’s Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Genome Diversity and Diseases Division, Mochtar Riady Institute for Nanotechnology, Jl. Boulevard Jenderal Sudirman 1688, Lippo Karawaci, Banten, Tangerang, 15811, Indonesia; Department of Surgical Oncology, Dr. Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomical Pathology, Dr. Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Hematology and Medical Oncology, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Department of Nutrition, Dr. Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Objective: Breast cancer is the leading cause of cancer incidence and mortality among Indonesian women. A comprehensive investigation is required to enhance the early detection of this disease. Mitochondrial DNA copy number (mtDNA-CN) and relative telomere length (RTL) have been proposed as potential biomarkers for several cancer risks, as they are linked through oxidative stress mechanisms. We conducted a case–control study to examine peripheral blood mtDNA-CN and RTL patterns in Indonesian breast cancer patients (n = 175) and healthy individuals (n = 181). The relative ratios of mtDNA-CN and RTL were determined using quantitative real-time PCR (qPCR). Results: Median values of mtDNA-CN and RTL were 1.62 and 0.70 in healthy subjects and 1.79 and 0.73 in breast cancer patients, respectively. We found a positive association between peripheral blood mtDNA-CN and RTL (p < 0.001). In under 48 years old breast cancer patients, higher peripheral blood mtDNA-CN (mtDNA-CN ≥ 1.73 (median), p = 0.009) and RTL (continuous variable, p = 0.010) were observed, compared to the corresponding healthy subjects. We also found a significantly higher ‘High-High’ pattern of mtDNA-CN and RTL in breast cancer patients under 48 years old (p = 0.011). Our findings suggest that peripheral blood mtDNA-CN and RTL could serve as additional minimally invasive biomarkers for breast cancer risk evaluation. © The Author(s) 2024.
Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Case-Control Studies; DNA Copy Number Variations; DNA, Mitochondrial; Female; Humans; Indonesia; Middle Aged; Telomere; Telomere Homeostasis; mitochondrial DNA; tumor marker; adult; aged; blood; breast tumor; case control study; copy number variation; female; genetics; human; Indonesia; middle aged; telomere; telomere homeostasis
Government of Republic of Indonesia; Bundesministerium für Forschung und Technologie, BMFT; Eijkman Institute for Molecular Biology
This study was supported by a block grant from the Government of Republic of Indonesia through the Ministry of Research and Technology for the Eijkman Institute for Molecular Biology.
BioMed Central Ltd
17560500
38679744
Article
Q2
534
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