Publikasi Scopus 2024 per tanggal 31 Mei 2024 (409 artikel)

Authors

Kurniawan R.; Taslim N.A.; Hardinsyah H.; Syauki A.Y.; Idris I.; Aman A.M.; Permatasari H.K.; Wiyarta E.; Surya R.; Mayulu N.; Putra P.P.; Tjandrawinata R.R.; Tallei T.E.; Kim B.; Tsopmo A.; Nurkolis F.

Author_Full_Names

Kurniawan, Rudy (57990353000); Taslim, Nurpudji Astuti (57194571794); Hardinsyah, Hardinsyah (56586054400); Syauki, Andi Yasmin (57376214300); Idris, Irfan (16636857800); Aman, Andi Makbul (57193706169); Permatasari, Happy Kurnia (57194728338); Wiyarta, Elvan (57221521342); Surya, Reggie (56610805600); Mayulu, Nelly (57303104200); Putra, Purnawan Pontana (57222390016); Tjandrawinata, Raymond Rubianto (6603266135); Tallei, Trina Ekawati (57193317686); Kim, Bonglee (51663469700); Tsopmo, Apollinai

Author S Id

57990353000; 57194571794; 56586054400; 57376214300; 16636857800; 57193706169; 57194728338; 57221521342; 56610805600; 57303104200; 57222390016; 6603266135; 57193317686; 51663469700; 6602260089; 57226728465

Title

Pharmacoinformatics and cellular studies of algal peptides as functional molecules to modulate type-2 diabetes markers

Year

2024

Source Title

Future Foods

Volume

Issue

Art No

100354

Page Start

Page End

Page Count

Cited By

Link

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191446983&doi=10.1016%2fj.fufo.2024.100354&partnerID=40&md5=7ba8790954696285f27694dbeba70fd5

Affiliations

Graduate from School of Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Diabetes Connection Care, Eka Hospital Bumi Serpong Damai, Tangerang, 15321, Indonesia; Division of Clinical Nutrition, Department of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Division of Applied Nutrition, Faculty of Human Ecology, Department of Community Nutrition, IPB University, Bogor, Indonesia; Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Makassar, Indonesia; Department of Biochemistry and Biomolecular, Faculty of Medicine, University of Brawijaya, Malang, 65145, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Hospital, Jakarta, 10430, Indonesia; Department of Food Technology, Faculty of Engineering, Bina Nusantara University, Jakarta, 11480, Indonesia; Department of Nutrition, Faculty of Health Science, Muhammadiyah Manado University, Manado, 95249, Indonesia; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Andalas, Padang, 25163, Indonesia; Department of Biotechnology, Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, 12930, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, 95115, Indonesia; Department of Pathology, College of Korean Medicine, Kyung Hee University, Kyungheedae-Ro 26, Dong-Daemun-Gu, Seoul, 05254, South Korea; Food Science and Nutrition Program, Department of Chemistry, Carleton University, 1125 Colonel by Drive, Ottawa, ON K1S 5B6, Canada; Department of Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta, 55281, Indonesia

Authors With Affiliations

Kurniawan R., Graduate from School of Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia, Diabetes Connection Care, Eka Hospital Bumi Serpong Damai, Tangerang, 15321, Indonesia; Taslim N.A., Division of Clinical Nutrition, Department of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Hardinsyah H., Division of Applied Nutrition, Faculty of Human Ecology, Department of Community Nutrition, IPB University, Bogor, Indonesia; Syauki A.Y., Division of Clinical Nutrition, Department of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Idris I., Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Aman A.M., Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Makassar, Indonesia; Permatasari H.K., Department of Biochemistry and Biomolecular, Faculty of Medicine, University of Brawijaya, Malang, 65145, Indonesia; Wiyarta E., Department of Neurology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Hospital, Jakarta, 10430, Indonesia; Surya R., Department of Food Technology, Faculty of Engineering, Bina Nusantara University, Jakarta, 11480, Indonesia; Mayulu N., Department of Nutrition, Faculty of Health Science, Muhammadiyah Manado University, Manado, 95249, Indonesia; Putra P.P., Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Andalas, Padang, 25163, Indonesia; Tjandrawinata R.R., Department of Biotechnology, Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, 12930, Indonesia; Tallei T.E., Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, 95115, Indonesia; Kim B., Department of Pathology, College of Korean Medicine, Kyung Hee University, Kyungheedae-Ro 26, Dong-Daemun-Gu, Seoul, 05254, South Korea; Tsopmo A., Food Science and Nutrition Program, Department of Chemistry, Carleton University, 1125 Colonel by Drive, Ottawa, ON K1S 5B6, Canada; Nurkolis F., Department of Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta, 55281, Indonesia

Abstract

Novel dietary strategies are urgently needed to address the limitations of current management and treatment options of Type-2 Diabetes (T2D). Marine algae-derived peptides (MAP) represent a promising avenue, although, their potential remains mostly underexplored. This study employs pharmacoinformatics and in vitro methods to evaluate the antidiabetic properties of MAP and provide new insights their mechanisms to mitigate the prevalence of T2D. Through a systematic search and predictive modeling, peptides were identified and assessed for bioactivity, toxicity, and drug-likeness. Furthermore, molecular docking simulations with protein targets related to T2D identified binding sites that be used to optimize the activity of MAP. The structure-activity relationship profile of MAP reveals 13 candidates with probable activity (Pa) scores >0.4, indicative of insulin promoter. The peptide FDGIP (P13;Phe-Asp-Gly-Ile-Pro) from Caulerpa lentillifera had the best in silico assessment value compared to 50 other peptides and its activity was confirmed by in vitro data (e.g.EC50 60.4 and 57.9 for α-amylase and α-glucosidase inhibitions). Interestingly, in 3T3-L1 cells, P13 exhibited inhibitory activities against transcription factors and hormones (MAPK8-JNK1/PPARGC1A/Ghrelin/GLP-1/CPT-1) that can regulate blood sugar and decrease as anti-diabetes. P13 then appears to be a peptide with antidiabetic action that may be used in the formulation foods to manage T2D. © 2024 The Author(s)

Author Keywords

Algae; Diabetes; Functional food; MAPK8; Marine peptide; Metabolic syndrome

Index Keywords

Funding Details

Funding Text

Publisher

Elsevier B.V.

Issn

26668335

Isbn

Pubmed Id

Document Type

Article

Sjr Best Quartile

Sjr

682

Sjr Rank

7352