Publikasi Scopus 2024 per tanggal 31 Mei 2024 (409 artikel)

Authors

Saraswati K.; Tanganuchitcharnchai A.; Ongchaikupt S.; Mukaka M.; Day N.P.J.; Kevin Baird J.; Antonjaya U.; Myint K.S.A.; Dewi Y.P.; Yudhaputri F.A.; Haryanto S.; Diah Witari N.P.; Blacksell S.D.

Author_Full_Names

Saraswati, Kartika (57201491297); Tanganuchitcharnchai, Ampai (36344192400); Ongchaikupt, Sirada (59012871100); Mukaka, Mavuto (24465325200); Day, Nicholas P.J. (36071528500); Kevin Baird, J. (58995916200); Antonjaya, Ungke (36016109600); Myint, Khin S.A. (7003758970); Dewi, Yora P. (57215530838); Yudhaputri, Frilasita A. (56464244900); Haryanto, Sotianingsih (58771247200); Diah Witari, N.P. (59072889700); Blacksell, Stuart D. (6701801256)

Author S Id

57201491297; 36344192400; 59012871100; 24465325200; 36071528500; 58995916200; 36016109600; 7003758970; 57215530838; 56464244900; 58771247200; 59072889700; 6701801256

Title

Scrub typhus in Indonesia: A cross-sectional analysis of archived fever studies samples

Year

2024

Source Title

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volume

118

Issue

Art No

Page Start

321

Page End

327

Page Count

Cited By

Link

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85192027113&doi=10.1093%2ftrstmh%2ftrad094&partnerID=40&md5=291f947dfc811576685a768e78746dc7

Affiliations

Oxford University Clinical Research Unit Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7LG, United Kingdom; Exeins Health Initiative, Jakarta, 12870, Indonesia; Raden Mattaher Hospital, Jambi, 36122, Indonesia; Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, 36361, Indonesia; Faculty of Medicine and Health Sciences, Warmadewa University, Denpasar, Bali, 80235, Indonesia

Authors With Affiliations

Saraswati K., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7LG, United Kingdom; Tanganuchitcharnchai A., Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand; Ongchaikupt S., Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand; Mukaka M., Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7LG, United Kingdom; Day N.P.J., Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7LG, United Kingdom; Kevin Baird J., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7LG, United Kingdom; Antonjaya U., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Myint K.S.A., Exeins Health Initiative, Jakarta, 12870, Indonesia; Dewi Y.P., Exeins Health Initiative, Jakarta, 12870, Indonesia; Yudhaputri F.A., Exeins Health Initiative, Jakarta, 12870, Indonesia; Haryanto S., Raden Mattaher Hospital, Jambi, 36122, Indonesia, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, 36361, Indonesia; Diah Witari N.P., Faculty of Medicine and Health Sciences, Warmadewa University, Denpasar, Bali, 80235, Indonesia; Blacksell S.D., Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7LG, United Kingdom

Abstract

Background: Scrub typhus is an understudied vector-borne bacterial infection. Methods: We tested archived fever samples for scrub typhus seropositivity to begin charting its geographic distribution in Indonesia. We analysed 1033 serum samples from three sites. IgM and IgG enzyme-linked immunosorbent assay (ELISA) against Orientia tsutsugamushi was performed using Karp, Kato, Gilliam, TA 716 antigens. To determine the cutoff in the absence of a presumed unexposed population and gold standard tests, we identified the visual inflection point, performed change point analysis, and used finite mixture models. Results: The optical density cutoff values used for IgM and IgG were 0.49 and 0.13, respectively. Across all sites, IgM seropositivity was 4.6% (95% CI: 3.4 to 6.0%) while IgG seropositivity was 4.4% (95% CI: 3.3 to 5.8%). The overall seropositivity across sites was 8.8% (95% CI: 8.1 to 11.7%). The overall seropositivity for Jambi, Denpasar, Tabanan were 9.7% (95% CI: 7.0 to 13.3%), 8.0% (95% CI: 5.7 to 11.0%), 9.0% (95% CI: 6.1 to 13.0%), respectively. Conclusions: We conclude that O. tsutsugamushi exposure in humans occurred at all sites analysed and could be the cause of illness in some cases. Though it was not the main cause of acute fever in these locations, it is still important to consider scrub typhus in cases not responding to beta-lactam antibiotics. Future seroprevalence surveys and testing for scrub typhus in acute febrile illness studies will be essential to understand its distribution and burden in Indonesia. © The Author(s) 2024. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.

Author Keywords

Indonesia; Orientia tsutsugamushi; scrub typhus; serology

Index Keywords

Adult; Antibodies, Bacterial; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin G; Immunoglobulin M; Indonesia; Male; Middle Aged; Orientia tsutsugamushi; Scrub Typhus; Seroepidemiologic Studies; beta lactam antibiotic; immunoglobulin G; immunoglobulin M; bacterium antibody; immunoglobulin G; immunoglobulin M; adolescent; adult; Article; cross-sectional study; dengue; enzyme linked immunosorbent assay; female; fever; geographic distribution; human; human experiment; Indonesia; male; Orientia tsutsugamushi; scrub typhus; seroprevalence; serum; blood; enzyme linked immunosorbent assay; immunology; Indonesia; isolation and purification; middle aged; Orientia tsutsugamushi; scrub typhus; seroepidemiology

Funding Details

Centers for Disease Control and Prevention, CDC; Wellcome Trust, WT, (220211); Wellcome Trust, WT

Funding Text

Funding text 1: We are grateful for laboratory resources provided by Dr Decy Subekti (Oxford University Clinical Research Unit Indonesia). We are also thankful to Fitria Wulandari (Oxford University Clinical Research Unit Indonesia) for her support in the ethics application. This research was funded in whole, or in part, by the Wellcome Trust [Grant number 220211]. For the purpose of open access,

Publisher

Oxford University Press

Issn

00359203

Isbn

Pubmed Id

38205975

Document Type

Article

Sjr Best Quartile

Sjr

724

Sjr Rank

6819