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Publikasi Scopus 2025 per tanggal 31 Januari 2025 (67 artikel)
Publikasi Scopus 2025 per tanggal 31 Januari 2025 (67 artikel)
Putera, Ikhwanuliman (56485949000); La Distia Nora, Rina (56001881000); Dewi, Arlin Chyntia (59326465100); Suhada, Ditta Shabrina (59423052000); Cifuentes-González, Carlos (57222074348); Rojas-Carabali, William (57219659910); Patnaik, Gazal (57217867262); Mejia-Salgado, Germán (57407509800); Sitompul, Ratna (8312163900); Edwar, Lukman (55695047800); Susiyanti, Made (19640377300); Aziza, Yulia (57214455776); Biswas, Jyotirmay (7102648244); Gupta, Vishali (35452834800); de-la-Torre, Alejandra (158
Antiviral therapy for cytomegalovirus retinitis: A systematic review and meta-analysis
2025
Survey of Ophthalmology
70
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215
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85210104519&doi=10.1016%2fj.survophthal.2024.11.004&partnerID=40&md5=6502626a0bba5570d3e17497e306a2fc
Department of Ophthalmology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Kirana Eye Hospital, Jakarta, Indonesia; Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Internal Medicine, Section Allergy & Clinical Immunology, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands; Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Institute of Translational Medicine (IMT), Universidad Del Rosario Escuela de Medicina y Ciencias de la Salud, Bogotá, Colombia; Programme for Ocular Inflammation & Infection Translational Research, National Healthcare Group, Singapore, Singapore; Department of Bioinformatics, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Sankara Nethralaya, Tamil Nadu, Chennai, India; Advanced Eye Centre, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India; National Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital, United Kingdom; UCL-Institute of Ophthalmology, United Kingdom; National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore; Duke NUS Medical School, Singapore; Singapore Eye Research Institute, Singapore
Cytomegalovirus retinitis (CMVR) is a significant cause of blindness in patients with advanced acquired immunodeficiency syndrome (AIDS). There are no established guidelines for its treatment, resulting in varied antiviral approaches. We pooled data from 59 studies (4501 patients) to evaluate treatment variations and outcomes (CRD42022321088). Overall pooled estimates showed visual acuity improvement at 18 % (95 % CI: 7–41 %), inflammation resolution at 90 % (95 % CI: 81–95 %), retinal detachment at 11 % (95 % CI: 8–14 %), and recurrence at 19 % (95 % CI: 11–31 %). The main antiviral treatment approaches identified were: (1) intravenous antivirals alone in 33 studies, (2) intravitreal antivirals alone in 26 studies, (3) oral antivirals alone in 3 studies, and (4) a combination of systemic (oral or intravenous[IV]) and intravitreal antivirals in 7 studies, with varying schemes and durations. Ganciclovir was the predominant antiviral, with intravenous administration being the most reported (in 23 studies), followed by intravitreal administration (in 20 studies). While visual acuity improvement was comparable, inflammation resolution tended to be higher with intravitreal than with IV antivirals, though not statistically significant (88 %, 95 % CI: 69–96 % vs 75 %, 95 % CI: 35–94 %, p = 0.38). Retinitis progression rate for IV ganciclovir was lower than for those without ganciclovir. Inflammation recurrence was significantly lower in antiretroviral (ART)-treated compared to non-ART-treated HIV/AIDS patients (10 % (95 % CI: 4–20 %) vs 33 % (95 % CI: 19–50 %), p < 0.01). Neutropenia, particularly with ganciclovir, was the most reported adverse effect (up to 50 %). © 2024 The Authors
AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus Retinitis; Ganciclovir; Humans; Intravitreal Injections; Visual Acuity; ganciclovir; antivirus agent; ganciclovir; AIDS patient; anemia; antiviral therapy; cytomegalovirus retinitis; disease exacerbation; geographic distribution; human; maintenance therapy; meta analysis; nephrotoxicity; neutropenia; recurrent disease; retina detachment; Review; sepsis; seroprevalence; systematic review; thrombocytopenia; treatment duration; treatment outcome; visual acuity; AIDS-related opportunistic infections; cytomegalovirus retinitis; drug therapy; intravitreal drug administration
National Medical Research Council, NMRC; Ministry of Health, MOH, (MOH-CSAINV19nov-0003, MOH-CSAINV22jul-0004); Ministry of Health, MOH
This research received no specific grant from funding agencies in the public, commercial, or not-for-profit sectors. IP is supported by Indonesia Endowment Fund for Education (Lembaga Pengelola Dana Pendidikan \u2013 LPDP; Grant No: 0004535/MED/D/19/lpdp2021). The funding source had no involvement in the collection, analysis, interpretation, writing of the report, and the decision to submit the ar
Elsevier Inc.
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