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Publikasi Scopus 2010 s/d 2022
Publikasi Scopus 2010 s/d 2022
Factors associated with high alanine aminotransferase (ALT) and cirrhosis in people living with HIV on combination antiretroviral treatment (cART) in the Asia-Pacific
2022
Journal of Medical Virology
94
11
5451
5464
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85136124877&doi=10.1002%2fjmv.28019&partnerID=40&md5=58ee6b0f54ed95ae159eb297fcbf39a5
The Kirby Institute, UNSW, Sydney, NSW, Australia; Department of Internal Medicine, Division of Infectious Diseases, Yonsei University College of Medicine, Seoul, South Korea; Faculty of Medicine Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; TREAT Asia, amfAR—The Foundation for AIDS Research, Bangkok, Thailand; National Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia; Research, Institute for Health Sciences, Chiang Mai, Thailand; Bach Mai Hospital, Hanoi, Viet Nam; Taipei Veterans General Hospital, Taipei, Taiwan; CART CRS, Voluntary Health Services, Chennai, India; HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; University Malaya Medical Centre, Kuala Lumpur, Malaysia; Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Beijing Ditan Hospital, Capital Medical University, Beijing, China; Queen Elizabeth Hospital, Kowloon, Hong Kong; National Hospital for Tropical Diseases, Hanoi, Viet Nam; Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; BJ Medical College and Sassoon General Hospitals, Pune, India; Tan Tock Seng Hospital, Singapore, Singapore; National Centre for Infectious Diseases, Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore; National Center for Global Health and Medicine, Tokyo, Japan; Research, Institute for Tropical Medicine, Muntinlupa City, Philippines; Hospital Sungai Buloh, Sungai Buloh, Malaysia; Institute of Infectious Diseases, Pune, India
Liver disease is a growing burden among people living with HIV (PLHIV) in resource-limited settings. As an indicator of liver disease, risk factors of high alanine aminotransferase (ALT) and cirrhosis were assessed among PLHIV in the TREAT Asia HIV Observational Database (TAHOD). Patients on combination antiretroviral therapy (cART) with a pre-cART ALT measurement and at least one follow-up ALT measurement were included. Factors associated with high ALT (ALT levels > 5 times its upper limit of normal) were analyzed using repeated measure logistic regression over a 10-year follow-up period. Liver cirrhosis was defined as having an AST to Platelet Ratio Index score > 1.5, fibrosis-4 score > 3.25, or a clinical diagnosis of cirrhosis. Cox regression analysis stratified by site was used to analyze factors associated with cirrhosis among those in follow-up after 2015. Of 5182 patients, 101 patients (1.9%) had high ALT levels with hepatitis C virus (HCV) antibody positive (odds ratio [OR]: 4.98, 95% confidence interval [CI]: 2.82–8.77, p < 0.001) and ever high alcohol consumption (OR: 2.33, 95% CI: 1.00–5.46, p = 0.050) as likely factors. Among 6318 PLHIV in the liver cirrhosis analysis, 151 (2%) developed cirrhosis (incidence rate = 0.82 per 100 person-years). Those HCV-antibody positive (hazard ratio [HR]: 5.54, 95% CI: 3.75–8.18, p < 0.001) and had high alcohol consumption (HR: 2.06, 95% CI: 1.23–3.45, p = 0.006) were associated with liver cirrhosis. HCV-antibody positive and high alcohol consumption are factors associated with high ALT. With raised ALT levels as a known factor associated with liver cirrhosis, greater efforts are required in managing ALT levels and reducing the risk of developing liver cirrhosis among those positive for HCV-antibody and those who consume alcohol. © 2022 Wiley Periodicals LLC.
alanine aminotransferase; aminotransferase; antiretrovirus agent; efavirenz; hepatitis B surface antigen; lamivudine; nevirapine; tenofovir; tenofovir disoproxil; virus antibody; alanine aminotransferase; adult; alanine aminotransferase blood level; alanine aminotransferase level; alcohol consumption; antiretroviral therapy; Article; aspartate aminotransferase to platelet ratio index; body mass; CD4 lymphocyte count; cohort analysis; diabetes mellitus; female; fibrosis; follow up; glucose blood level; hepatitis C; Hepatitis C virus; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; liver cirrhosis; liver fibrosis; liver injury; liver toxicity; logistic regression analysis; low income country; major clinical study; male; men who have sex with men;
National Medical Research Council; Ministry of Health -Singapore; University of New South Wales
The study team would like to acknowledge all TAHOD study members, steering committee, and patients for their support. This study was supported by the TREAT Asia HIV Observational Database, which is funded by International Epidemiology Databases to Evaluate AIDS (IeDEA; U01AI069907). The Kirby Institute is funded by the Australian Government Department of Health and is affiliated with the Faculty o
John Wiley and Sons Inc
01466615
35869413
Article
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