Publikasi Scopus 2010 s/d 2022

Authors_(Last_Name)

Chozie N.A., Gatot D., Sudarmanto B., Susanah S., Purnamasari R., Widjajanto P.H., Nugroho S., Rasiyanti O., Puspitasari D., Riza M., Larasati M.C.S., Adiyanti S.S., Saraswati M.C., Primacakti F., Pediatric Hematology-Oncology Working Group of the Indonesian Pediatric Society

Author S Id

57194329830;6508292159;6503987451;56070321700;58076364600;36629603700;57969372400;58076089400;58076364700;57195184466;57221724715;57191952811;57789286700;57208602430;

Title

FVIII inhibitor surveillance in children with hemophilia A in Indonesia: a report from the Indonesian Pediatric Hematology-Oncology Working Group

Year

2022

Source Title

Blood Research

Volume

Issue

Art No

Page Start

272

Page End

277

Page Count

Cited By

Link

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85146821360&doi=10.5045%2fbr.2022.2022153&partnerID=40&md5=fd41fb40c3e1a18da2e14b9db7f79cad

Affiliations

Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Child Health, Dr. Kariadi Hospital, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia; Department of Child Health, Dr. Hasan Sadikin General Hospital, Bandung, Faculty of Medicine, Universitas Padjajaran, West Java, Indonesia; Department of Child Health, Tangerang General Hospital, Banten, Indonesia; Department of Child Health, Dr. Sardjito Hospital, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Child Health, Dr. Saiful Anwar Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Child Health, H. Adam Malik General Hospital, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Child Health, Dr. Moh. Hoesin General Hospital, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia; Department of Child Health, Dr. Moewardi Hospital, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia; Department of Child Health, Dr. Soetomo General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Clinical Pathology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Authors With Affiliations

Chozie, N.A., Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Gatot, D., Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sudarmanto, B., Department of Child Health, Dr. Kariadi Hospital, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia; Susanah, S., Department of Child Health, Dr. Hasan Sadikin General Hospital, Bandung, Faculty of Medicine, Universitas Padjajaran, West Java, Indonesia; Purnamasari, R., Department of Child Health, Tangerang General Hospital, Banten, Indonesia; Widjajanto, P.H., Department of Child Health, Dr. Sardjito Hospital, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Nugroho, S., Department of Child Health, Dr. Saiful Anwar Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Rasiyanti, O., Department of Child Health, H. Adam Malik General Hospital, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Puspitasari, D., Department of Child Health, Dr. Moh. Hoesin General Hospital, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia; Riza, M., Department of Child Health, Dr. Moewardi Hospital, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia; Larasati, M.C.S., Department of Child Health, Dr. Soetomo General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Adiyanti, S.S., Department of Clinical Pathology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Saraswati, M.C., Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Primacakti, F., Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pediatric Hematology-Oncology Working Group of the Indonesian Pediatric Society

Abstract

Background Factor VIII (FVIII) inhibitor diagnosis and surveillance in Indonesia are challenging owing to geographic conditions and the lack of laboratory facilities nationwide for inhibitor assays. This study aimed to determine the prevalence of FVIII inhibitors in children diagnosed with hemophilia A (HA) in Indonesia. Methods A cross-sectional study was conducted in 12 hospitals in eight provinces of Indonesia between 2020 and 2021. Factor VIII inhibitor screening was performed in a central hemostasis laboratory for all children with HA (≤18 yr) who had received a minimum of 10 exposure days to clotting factor concentrates. The FVIII inhibitor titer was determined using the Bethesda assay. Results Children (388) were enrolled in this study, including 219 (56.4%), 131 (33.8%), and 38 (9.4%) with severe, moderate, and mild HA, respectively. The prevalence of children who developed FVIII inhibitors was 37 out of 388 (9.6%). Factor VIII inhibitors were found in 25/219 (11.4%) severe, 11/131 (8.3%) moderate, and 1/38 (2.6%) children with mild HA. Thirteen children had low-titer inhibitors and 24 had high-titer inhibitors, with a median of 9.44 (1.48‒412.0) Bethesda Units. Among 13 children with low-titer inhibitors, eight underwent a confirmation test, of which five tested negative and were classified as transient. A significant difference in annual joint bleeding rate was found between patients with low and high inhibitor titers and those without inhibitors (P＜0.001). Conclusion Factor VIII inhibitor prevalence in Indonesia was relatively low. However, the risk factors that may contribute to FVIII inhibitor development among Indonesian patients require further study. © 2022 Korean Society of Hematology.

Author Keywords

Factor VIII; Hemophilia A; Inhibitor

Index Keywords

blood clotting factor 8 inhibitor; blood clotting factor concentrate; adolescent; adult; appendectomy; Article; brain hemorrhage; child; circumcision; clinical article; controlled study; cross-sectional study; disease severity; female; hemarthrosis; hemophilia A; hemostasis; human; iliopsoas muscle; Indonesia; Indonesian; infant; male; multicenter study; muscle bleeding; preschool child; prevalence; school child; tooth extraction

Funding Details

Haemophilia Society

Funding Text 1

We thank the Indonesian Hemophilia Society for their support in reaching out to hemophilia patients living in the cities/provinces participating in this study and the Prodia Laboratory for their assistance in collecting and delivering blood samples. The FVIII inhibitor surveillance project was funded by Roche Indonesia. No honoraria were received by the authors for the manuscript writing

Funding Text 2

Funding Text 3

Publisher

Korean Society of Hematology

Issn

2287979X

Isbn

Pubmed Id

Document Type

Article

Sjr Best Quartile

Sjr

407

Sjr Rank

11912