Publikasi Scopus 2010 s/d 2022

Publikasi Scopus 2010 s/d 2022

Lagatie O., Verheyen A., Van Asten S., Odiere M.R., Djuardi Y., Levecke B., Vlaminck J., Mekonnen Z., Dana D., T’Kindt R., Sandra K., van Outersterp R., Oomens J., Lin R., Dillen L., Vreeken R., Cuyckens F., Stuyver L.J.
6506701998;26636089100;57219157131;35225382000;6507800820;23091505100;37023677600;24491286700;56585698100;57216923480;6603267434;57200425084;6701360071;57219159434;57190567310;6602559274;57898294300;7004164328;
2-Methyl-pentanoyl-carnitine (2-MPC): a urine biomarker for patent Ascaris lumbricoides infection
2020
Scientific Reports
10
1
15780
10
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091485278&doi=10.1038%2fs41598-020-72804-y&partnerID=40&md5=e0bb5a1fc65d52a567235acb9d944972
Janssen Global Public Health, Janssen R&D, Turnhoutseweg 30, Beerse, 2340, Belgium; Discovery Sciences, Janssen R&D, Turnhoutseweg 30, Beerse, 2340, Belgium; Centre for Global Health Research, Kenya Medical Research Institute, P. O. Box 1578, Kisumu, 40100, Kenya; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Virology, Parasitology and Immunology, Ghent University, Salisburylaan 133, Merelbeke, 9820, Belgium; School of Medical Laboratory Sciences, Jimma University, Jimma, Ethiopia; Research Institute for Chromatography, President Kennedypark 26, Kortrijk, 8500, Belgium; FELIX Laboratory, Faculty of Science, Radboud University, Toernooiveld 7, Nijmegen, 6525 ED, Netherlands; Janssen R&D, Welsh & McKean Road, Spring House, PA 19477-0776, United States
Lagatie, O., Janssen Global Public Health, Janssen R&D, Turnhoutseweg 30, Beerse, 2340, Belgium; Verheyen, A., Janssen Global Public Health, Janssen R&D, Turnhoutseweg 30, Beerse, 2340, Belgium; Van Asten, S., Discovery Sciences, Janssen R&D, Turnhoutseweg 30, Beerse, 2340, Belgium; Odiere, M.R., Centre for Global Health Research, Kenya Medical Research Institute, P. O. Box 1578, Kisumu, 40100, Kenya; Djuardi, Y., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Levecke, B., Department of Virology, Parasitology and Immunology, Ghent University, Salisburylaan 133, Merelbeke, 9820, Belgium; Vlaminck, J., Department of Virology, Parasitology and Immunology, Ghent University, Salisburylaan 133, Merelbeke, 9820, Belgium; Mekonnen, Z., School of Medical Laboratory Sciences, Jimma University, Jimma, Ethiopia; Dana, D., School of Medical Laboratory Sciences, Jimma University, Jimma, Ethiopia; T’Kindt, R., Research Institute for Chromatography, President Kennedypark 26, Kortrijk, 8500, Belgium; Sandra, K., Research Institute for Chromatography, President Kennedypark 26, Kortrijk, 8500, Belgium; van Outersterp, R., FELIX Laboratory, Faculty of Science, Radboud University, Toernooiveld 7, Nijmegen, 6525 ED, Netherlands; Oomens, J., FELIX Laboratory, Faculty of Science, Radboud University, Toernooiveld 7, Nijmegen, 6525 ED, Netherlands; Lin, R., Janssen R&D, Welsh & McKean Road, Spring House, PA 19477-0776, United States; Dillen, L., Discovery Sciences, Janssen R&D, Turnhoutseweg 30, Beerse, 2340, Belgium; Vreeken, R., Discovery Sciences, Janssen R&D, Turnhoutseweg 30, Beerse, 2340, Belgium; Cuyckens, F., Discovery Sciences, Janssen R&D, Turnhoutseweg 30, Beerse, 2340, Belgium; Stuyver, L.J., Janssen Global Public Health, Janssen R&D, Turnhoutseweg 30, Beerse, 2340, Belgium
Infections with intestinal worms, such as Ascaris lumbricoides, affect hundreds of millions of people in all tropical and subtropical regions of the world. Through large-scale deworming programs, World Health Organization aims to reduce moderate-to-heavy intensity infections below 1%. Current diagnosis and monitoring of these control programs are solely based on the detection of worm eggs in stool. Here we describe how metabolome analysis was used to identify the A. lumbricoides-specific urine biomarker 2-methyl pentanoyl carnitine (2-MPC). This biomarker was found to be 85.7% accurate in determining infection and 90.5% accurate in determining a moderate-to-heavy infection. Our results also demonstrate that there is a correlation between 2-MPC levels in urine and A. lumbricoides DNA detected in stool. Furthermore, the levels of 2-MPC in urine were shown to rapidly and strongly decrease upon administration of a standard treatment (single oral dose of 400 mg albendazole). In an Ascaris suum infection model in pigs, it was found that, although 2-MPC levels were much lower compared to humans, there was a significant association between urinary 2-MPC levels and both worm counts (p = 0.023) and the number of eggs per gram (epg) counts (p < 0.001). This report demonstrates that urinary 2-MPC can be considered an A. lumbricoides-specific biomarker that can be used to monitor infection intensity. © 2020, The Author(s).
biological marker; carnitine; animal; ascariasis; Ascaris lumbricoides; chemistry; metabolism; metabolomics; physiology; pig; urine; Animals; Ascariasis; Ascaris lumbricoides; Biomarkers; Carnitine; Metabolomics; Swine
Bill and Melinda Gates Foundation; Nederlandse Organisatie voor Wetenschappelijk Onderzoek
The study was funded by the Bill and Melinda Gates Foundation (Grant # OPP1192231). IRIS experiments at FELIX were made possible through funding from the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) under contracts LIFT-731.017.419 and TTW-15769.
Nature Research
20452322
32978457
Article
Q1
1240
3130

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