Publikasi Scopus 2010 s/d 2022

3657

Authors_(Last_Name)

Bayani G.F.E., Marpaung N.L.E., Simorangkir D.A.S., Sianipar I.R., Ibrahim N., Kartinah N.T., Mansur I.G., Purba J.S., Ilyas E.I.I.

Author S Id

57195935050;57195939056;57195937249;55486707100;56609777400;57192914846;6603222374;56702981900;57126185600;

Title

Anti-inflammatory Effects of Hibiscus Sabdariffa Linn. on the IL-1β/IL-1ra Ratio in Plasma and Hippocampus of Overtrained Rats and Correlation with Spatial Memory

Year

2018

Source Title

The Kobe journal of medical sciences

Volume

Issue

Art No

Page Start

E73

Page End

E83

Page Count

Cited By

Link

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85055843515&partnerID=40&md5=a6c30affa70a51aa566ce4716a5bfe6c

Affiliations

Biomedical Science Master Program Student-Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Medical Physiology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Neurology, Jakarta, Indonesia

Authors With Affiliations

Bayani, G.F.E., Biomedical Science Master Program Student-Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Marpaung, N.L.E., Biomedical Science Master Program Student-Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Simorangkir, D.A.S., Biomedical Science Master Program Student-Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sianipar, I.R., Department of Medical Physiology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Ibrahim, N., Department of Medical Physiology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kartinah, N.T., Department of Medical Physiology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Mansur, I.G., Department of Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Purba, J.S., Department of Neurology, Jakarta, Indonesia; Ilyas, E.I.I., Department of Medical Physiology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia

Abstract

Overtraining leads to an increase in IL-1β systemically due to muscle microtrauma, which affects the hippocampus, an important structure in spatial memory consolidation. The administration of Hibiscus sabdariffa Linn is expected to decrease IL-1β and increase IL-1ra, thereby potentially preventing impairments in spatial memory consolidation. This research was an experimental study using 20 male Wistar rats. The overtraining of Wistar rats altered the ratio of IL-1β/IL-1ra in the plasma and hippocampus. Moreover, this overtraining impaired spatial memory consolidation. The methanol extract of H. sabdariffa improved spatial memory consolidation in Wistar rats and prevented impairment in spatial memory consolidation by maintaining the ratio of IL-1β/IL-1ra in the plasma and hippocampus of Wistar rats who experienced overtraining. H. sabdariffa is a potent anti-inflammatory substance that prevents impairments in spatial memory consolidation in overtrained Wistar rats.

Author Keywords

overtraining; Hibiscus sabdariffa Linn.; hippocampus; IL-1ra; IL-1β; Plasma; spatial memory consolidation

Index Keywords

antiinflammatory agent; interleukin 1 receptor blocking agent; interleukin 1beta; plant extract; animal; blood; drug effect; Hibiscus; hippocampus; male; medicinal plant; memory consolidation; metabolism; microtrauma; pathophysiology; physiology; phytotherapy; psychology; rat; spatial memory; Wistar rat; Animals; Anti-Inflammatory Agents; Hibiscus; Hippocampus; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Male; Memory Consolidation; Microtrauma, Physical; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Spatial Memory

Funding Details

Funding Text 1

Funding Text 2

Funding Text 3

Publisher

NLM (Medline)

Issn

18830498

Isbn

Pubmed Id

30381729

Document Type

Article

Sjr Best Quartile

Sjr

214

Sjr Rank

17121