Publikasi Scopus 2010 s/d 2022

Abdulla S., Achan J., Adam I., Alemayehu B.H., Allan R., Allen E.N., Anvikar A.R., Arinaitwe E., Ashley E.A., Asih P.B.S., Awab G.R., Barnes K.I., Bassat Q., Baudin E., Bjorkman A., Bompart F., Bonnet M., Borrmann S., Bousema T., Carrara V.I., Cenci F., Checchi F., Cot M., Dahal P., D'Alessandro U., Deloron P., Djimde A., Dondorp A., Dorsey G., Doumbo O.K., Drakeley C.J., Duparc S., Espie E., Faiz A., Falade C.O., Fanello C., Faucher J.-F., Faye B., Filler S., Fofana B., Fogg C., Gansane A., Gaye O., Genton B., Gething P.W., Gonzalez R., Grandesso F., Greenwood B., Grivoyannis A., Guerin P.J., Hamed K., Hatz C., Hay S.I., Hodel E.M., Humphreys G.S., Hwang J., Janssens B., Jima D., Juma E., Kachur S.P., Kager P., Kamya M.R., Kapulu M., Karema C., Kayentao K., Kiechel J.R., Kofoed P.-E., Lameyre V., Lee S.J., Lell B., Lima N., Marsh K., Mårtensson A., Massougbodji A., Mayxay M., McGready R., Menan H., Menendez C., Mens P., Meremikwu M., Mockenhaupt F.P., Moreira C., Nabasumba C., Nambozi M., Ndiaye J.-L., Newton P.N., Ngasala B.E., Nosten F., Nsanzabana C., Offianan A.T., Oguike M., Ogutu B.R., Olliaro P., Omar S.A., Osorio L., Owusu-Agyei S., Penali L.K., Pene M., Peshu J., Piola P., Premji Z., Price R.N., Ramharter M., Rombo L., Roper C., Rosenthal P.J., Sagara I., Sawa P., Schallig H.D.F.H., Schramm B., Shekalaghe S.A., Sibley C.H., Sirima S., Smithuis F., Sow D., Staedke S.G., Stepniewska K., Sutanto I., Sutherland C.J., Swarthout T.D., Syafruddin D., Sylla K., Talisuna A.O., Taylor W.R., Temu E.A., Kuile F.T., Tinto H., Tjitra E., Ursing J., Valecha N., Van Den Broek I., Van Herp M., Van Vugt M., Ward S.A., White N.J., Winstanley P.A., Woodrow C.J., Yeka A., Zwang J., WWARN Gametocyte Study Group
57203043991;23471656200;7006543992;49460948100;7201443618;29067523000;57216302575;35241738600;57205247633;6507080729;36016082300;7101713025;23024176000;26665961500;7006344603;57202908801;8276814700;7005941216;6506709831;6603063352;57715884700;57202349535;7006762308;52763242800;7005042050;7006979740;6603275857;35462577600;7004468886;7005026392;7003491251;26641860800;14053736100;7003330646;6603081481;6602452712;57208500796;57223210756;7005482012;23392379600;57207561603;16039073300;34975070700;35501901200;57193559189;55832485400;57216302468;36040863900;36140239000;57216302532;6701358148;7005583701;7101875313;56549101600;56612907900;35067936600;55910498800;8969554400;24076244800;7004408469;14524910200;6603886030;42961564900;57202557522;6506419350;57207899556;7004008613;16744320900;35272455900;35467226900;57204307223;7201684011;8983786500;7003414712;6603556481;7005266624;57217244173;55942254700;8271302700;18536940700;7003334445;56012570300;23019444800;35722654700;6602504140;57202763590;15840318200;57220538765;8320965400;35790748500;36010742300;6701594307;7005144054;7101977670;56229326100;6602311348;6602399298;15064813800;27867947900;57203122850;35460640900;55544802200;6601932667;7007173950;7005764994;55137938300;8600258200;24469253200;7004712193;37110248800;16239751900;7102504139;7801642290;6602715002;6603822766;6602233564;6701362958;6603791639;7102816903;14631395700;6602774565;35303990200;57208476202;57217494731;6603650274;7005757679;55975227100;57204151009;15924337000;7004555676;24765523600;57204887280;57469021400;7402385955;7401767314;56246147900;6603607628;10641616700;12809052800;
Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: A systematic review and meta-analysis of individual patient data
2016
BMC Medicine
14
1
79
84
Ifakara Health Institute, Dar es Salaam, Tanzania; Uganda Malaria Surveillance Project, Kampala, Uganda; Medical Research Council Unit, Fajara, Gambia; Faculty of Medicine, University of Khartoum, Khartoum, Sudan; ICAP, Mailman School of Public Health, Columbia University, New York, United States; MENTOR Initiative, Crawley, United Kingdom; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa; National Institute of Malaria Research, New Delhi, India; Infectious Diseases Research Collaboration, Kampala, Uganda; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand; Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Eijkman Institute for Molecular Biology, Indonesia; Mahidol Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand; Ministry of Public Health, Islamic Republic of Afghanistan, Kabul, Afghanistan; WWARN, Oxford, United Kingdom; Centro de Investigacao em Saude de Manhica, Manhica, Mozambique; ISGlobal, Centre de Recerca en Salut Internacional de Barcelona (CRESIB), Hospital Clinic, Universitat de Barcelona, Barcelona, Spain; Epicentre, Paris, France; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden; Sanofi, Access to Medicines, Paris, France; Epicentre, Mbarara, Uganda; Institute de Recherche pour le Developpement UMI233, INSERM U1175, Universite de Montpellier, Montelier, France; Kenya Medical Research Institute, Wellcome Trust Research Programme, Kilifi, Kenya; Institute for Tropical Medicine, University of Tubingen, Germany; Department of Infection and Immunity, London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom; Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Njimegen, Netherlands; Sigma Tau, Rome, Italy; IRD, Mother and Child Health in the Tropics Research Unit, Universite Paris Descartes, Paris, France; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; LSHTM, London, United Kingdom; Institute of Tropical Medicine, Antwerp, Belgium; Institut de Recherche pour le Developpement, Mother and Child Faced with Tropical Infections Research Unit, Paris, France; PRES Paris Sorbonne Cite, Universite Paris Descartes, Paris, France; Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto-Stomatology, University of Bamako, Bamako, Mali; Department of Medicine, University of California San Francisco, San Francisco, United States; Department of Infection and Immunity, LSHTM, London, United Kingdom; Medicines for Malaria Venture, Geneva, Switzerland; Dev Care Foundation, Bangladesh; Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria; Institut de Recherche pour le Developpement (IRD), Mother and Child Health in the Tropics Research Unit, Paris, France; Faculte de Pharmacie, Universite Paris Descartes, Paris, France; Department of Infectious Diseases, Besancon University Medical Center, Besancon, France; Global Fund to Fight AIDS, Tuberculosis and Malaria, Geneva, Switzerland; University of Portsmouth, Portsmouth, United Kingdom; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso; Department of Medical Parasitology, Medical Faculty, Universite Cheikh Anta Diop, Dakar, Senegal; Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; Division of Infectious Diseases, Department of Ambulatory Care and Community Medicine, University Hospital, Lausanne, Switzerland; Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, United Kingdom; ISGlobal, Barcelona Ctr. Int Health Res. (CRESIB), Hospital Clínic, Universitat de Barcelona, Spain; Department of Diseases Control, LSHTM, London, United Kingdom; University of Washington, United States; Novartis Pharmaceuticals Corporation, East Hanover, United States; Medical Department, Swiss Tropical Institute, Basel, Switzerland; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Institute for Health Metrics and Evaluation, University of Washington, Seattle, United States; Swiss Tropical Institute, Public Health Institute, Basel, Switzerland; Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; U.S. Centers for Disease Control and Prevention, Atlanta, United States; Global Health Group, University of California San Francisco, San Francisco, United States; Médecins Sans Frontières, Operational Centre Brussels, Brussels, Belgium; Federal Ministry of Health, Addis Ababa, Ethiopia; Kenya Medical Research Institute, Nairobi, Kenya; Academic Medical Centre, Amsterdam, Netherlands; Makerere University, College of Health Sciences, Kampala, Uganda; Malaria and Other Parasitic Diseases Division, RBC, Ministry of Health, Kigali, Rwanda; Malaria Research and Training Centre, Department of Epidemiology of Parasitologic Diseases, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Mali; Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland; Projecto de Saúde de Bandim, Bissau, Guinea-Bissau; Health Services Research Unit, Lillebaelt Hospital, IRS University of Southern Denmark, Vejle, Denmark; Department of Paediatrics, Kolding Hospital, Kolding, Denmark; Institute for Tropical Medicine, University of Tubingen, Tubingen, Germany; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Médecins Sans Frontières, Operational Centre Barcelona Athens, Barcelona, Spain; Department of Women's and Children's Health, International Maternal and Child Health (IMCH), Upssala University, Uppsala, Sweden; Centre d'Etudes et de Recherche sur le Paludisme Associe a la Grossesse et a l'Enfant (CERPAGE), Faculté des Sciences de la Santé (FSS), Université d'Abomey-Calavi, Cotonou, Benin; Lao-Oxford-Mahosot Hospital, Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Laos; Faculty of Postgraduate Studies, University of Health Sciences, Vientiane, Laos; Department of Parasitology, Faculty of Pharmacy, University of Cocody, Abidjan, Cote d'Ivoire; Barcelona Institute for Global Health (ISGlobal), Hospital Clinic, University of Barcelona, Spain; CISM, Manhiça Health Research Center, Manhiça, Mozambique; Royal Tropical Institute, KIT Biomedical Research, Amsterdam, Netherlands; Division of Infectious Diseases, Center for Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Netherlands; Department of Paediatrics, University of Calabar, Nigeria Institute of Tropical Diseases Research and Prevention, Calabar, Nigeria; Institute of Tropical Medicine and International Health, Charite-Universitatsmedizin Berlin, Germany; Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda; Tropical Diseases Research Centre, Ndola, Zambia; Parasitology and Mycology Laboratory, Medical Faculty, Université Cheikh Anta Diop, Dakar, Senegal; Lao-Oxford-Mahosot Hospital, Wellcome Trust Research Unit, Mahosot Hospital, Vientiane, Laos; Department of Parasitology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Malaria Research, Infectious Disease Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden; Malariology Department, Institut Pasteur, Abidjan, Cote d'Ivoire; Department of Immunology and Infection, LSHTM, London, United Kingdom; Kenya Medical Research Institute, United States Army Medical Research Unit, Kisumu, Kenya; UNICEF/UNDP/World Bank, WHO Special Programme for Research and Training in Tropical Diseases (WHO/TDR), Geneva, Switzerland; International Centre for Insect Physiology and Ecology (ICIPE), Mbita Point, Kenya; Facultad de Salud, Universidad del Valle, Cali, Colombia; Kintampo Health Research Centre, Kintampo, Ghana; WWARN, Dakar, Senegal; Department of Medical Parasitology, Medical Faculty, Université Cheikh Anta Diop, Dakar, Senegal; Institut Pasteur de Madagascar, Antananarivo, Madagascar; Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Menzies School of Health Research, Charles Darwin University, Darwin, Australia; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University Vienna, Austria; Institut für Tropenmedizin, Universität Tübingen, Germany; Centre de Recherches Medicales de Lambaréné, Gabon; Infectious Diseases Unit, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden; Human Health Division, International Centre for Insect Physiology and Ecology, Mbita, Kenya; Ifakara Health Institute, Bagamoyo, Tanzania; Department of Genome Sciences, University of Washington, Seattle, United States; Myanmar Oxford Clinical Research Unit (MOCRU), Yangon, Myanmar; Medical Action Myanmar, Yangon, Myanmar; Service de Parasitologie, Medical Faculty, Université Cheikh Anta Diop, Dakar, Senegal; Department of Clinical Research, LSHTM, London, United Kingdom; Infectious Disease Research Collaboration, Kampala, Uganda; Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Médecins Sans Frontières, London, United Kingdom; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Service de Parasitologie-Mycologie Médicale, Université Cheikh Anta Diop, Dakar, Senegal; University of Oxford, KEMRI, Wellcome Trust Research Programme, Nairobi, Kenya; Institute for Biomechanics, Department of Health Science and Technology, Eidgenössische Technische Hochschule Zürich, Zürich, Switzerland; Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland; Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Kenya Medical Research Institute (KEMRI), Centre for Global Health Research, Kisumu, Kenya; Institut de Recherce en Sciences de la Sante, Bobo Dioulasso, Burkina Faso; Centre Muraz, Bobo Dioulasso, Burkina Faso; National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Projecto de Saúde de Bandim, Indepth Network, Bissau, Guinea-Bissau; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands; Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom
Abdulla, S., Ifakara Health Institute, Dar es Salaam, Tanzania; Achan, J., Uganda Malaria Surveillance Project, Kampala, Uganda, Medical Research Council Unit, Fajara, Gambia; Adam, I., Faculty of Medicine, University of Khartoum, Khartoum, Sudan; Alemayehu, B.H., ICAP, Mailman School of Public Health, Columbia University, New York, United States; Allan, R., MENTOR Initiative, Crawley, United Kingdom; Allen, E.N., Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa; Anvikar, A.R., National Institute of Malaria Research, New Delhi, India; Arinaitwe, E., Infectious Diseases Research Collaboration, Kampala, Uganda; Ashley, E.A., Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Asih, P.B.S., Eijkman Institute for Molecular Biology, Indonesia; Awab, G.R., Mahidol Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand, Ministry of Public Health, Islamic Republic of Afghanistan, Kabul, Afghanistan; Barnes, K.I., Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa, WWARN, Oxford, United Kingdom; Bassat, Q., Centro de Investigacao em Saude de Manhica, Manhica, Mozambique, ISGlobal, Centre de Recerca en Salut Internacional de Barcelona (CRESIB), Hospital Clinic, Universitat de Barcelona, Barcelona, Spain; Baudin, E., Epicentre, Paris, France; Bjorkman, A., Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden; Bompart, F., Sanofi, Access to Medicines, Paris, France; Bonnet, M., Epicentre, Mbarara, Uganda, Institute de Recherche pour le Developpement UMI233, INSERM U1175, Universite de Montpellier, Montelier, France; Borrmann, S., Kenya Medical Research Institute, Wellcome Trust Research Programme, Kilifi, Kenya, Institute for Tropical Medicine, University of Tubingen, Germany; Bousema, T., Department of Infection and Immunity, London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom, Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Njimegen, Netherlands; Carrara, V.I., Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand, Mahidol Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand; Cenci, F., Sigma Tau, Rome, Italy; Checchi, F., Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden; Cot, M., IRD, Mother and Child Health in the Tropics Research Unit, Universite Paris Descartes, Paris, France; Dahal, P., WWARN, Oxford, United Kingdom, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; D'Alessandro, U., Medical Research Council Unit, Fajara, Gambia, LSHTM, London, United Kingdom, Institute of Tropical Medicine, Antwerp, Belgium; Deloron, P., Institut de Recherche pour le Developpement, Mother and Child Faced with Tropical Infections Research Unit, Paris, France, PRES Paris Sorbonne Cite, Universite Paris Descartes, Paris, France; Djimde, A., Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto-Stomatology, University of Bamako, Bamako, Mali; Dondorp, A., Mahidol Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Dorsey, G., Department of Medicine, University of California San Francisco, San Francisco, United States; Doumbo, O.K., Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto-Stomatology, University of Bamako, Bamako, Mali; Drakeley, C.J., Department of Infection and Immunity, LSHTM, London, United Kingdom; Duparc, S., Medicines for Malaria Venture, Geneva, Switzerland; Espie, E., Epicentre, Paris, France; Faiz, A., Dev Care Foundation, Bangladesh; Falade, C.O., Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria; Fanello, C., Mahidol Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand; Faucher, J.-F., Institut de Recherche pour le Developpement (IRD), Mother and Child Health in the Tropics Research Unit, Paris, France, Faculte de Pharmacie, Universite Paris Descartes, Paris, France, Department of Infectious Diseases, Besancon University Medical Center, Besancon, France; Faye, B., Global Fund to Fight AIDS, Tuberculosis and Malaria, Geneva, Switzerland; Filler, S., Global Fund to Fight AIDS, Tuberculosis and Malaria, Geneva, Switzerland; Fofana, B., Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto-Stomatology, University of Bamako, Bamako, Mali; Fogg, C., University of Portsmouth, Portsmouth, United Kingdom; Gansane, A., Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso; Gaye, O., Department of Medical Parasitology, Medical Faculty, Universite Cheikh Anta Diop, Dakar, Senegal; Genton, B., Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland, Division of Infectious Diseases, Department of Ambulatory Care and Community Medicine, University Hospital, Lausanne, Switzerland; Gething, P.W., Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, United Kingdom; Gonzalez, R., Centro de Investigacao em Saude de Manhica, Manhica, Mozambique, ISGlobal, Barcelona Ctr. Int Health Res. (CRESIB), Hospital Clínic, Universitat de Barcelona, Spain; Grandesso, F., Epicentre, Paris, France; Greenwood, B., Department of Diseases Control, LSHTM, London, United Kingdom; Grivoyannis, A., University of Washington, United States; Guerin, P.J., WWARN, Oxford, United Kingdom, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Hamed, K., Novartis Pharmaceuticals Corporation, East Hanover, United States; Hatz, C., Medical Department, Swiss Tropical Institute, Basel, Switzerland; Hay, S.I., Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Institute for Health Metrics and Evaluation, University of Washington, Seattle, United States; Hodel, E.M., Swiss Tropical Institute, Public Health Institute, Basel, Switzerland, Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Humphreys, G.S., WWARN, Oxford, United Kingdom, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Hwang, J., U.S. Centers for Disease Control and Prevention, Atlanta, United States, Global Health Group, University of California San Francisco, San Francisco, United States; Janssens, B., Médecins Sans Frontières, Operational Centre Brussels, Brussels, Belgium; Jima, D., Federal Ministry of Health, Addis Ababa, Ethiopia; Juma, E., Kenya Medical Research Institute, Nairobi, Kenya; Kachur, S.P., U.S. Centers for Disease Control and Prevention, Atlanta, United States; Kager, P., Academic Medical Centre, Amsterdam, Netherlands; Kamya, M.R., Makerere University, College of Health Sciences, Kampala, Uganda; Kapulu, M., Kenya Medical Research Institute, Wellcome Trust Research Programme, Kilifi, Kenya, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Karema, C., Malaria and Other Parasitic Diseases Division, RBC, Ministry of Health, Kigali, Rwanda; Kayentao, K., Malaria Research and Training Centre, Department of Epidemiology of Parasitologic Diseases, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Mali; Kiechel, J.R., Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland; Kofoed, P.-E., Projecto de Saúde de Bandim, Bissau, Guinea-Bissau, Health Services Research Unit, Lillebaelt Hospital, IRS University of Southern Denmark, Vejle, Denmark, Department of Paediatrics, Kolding Hospital, Kolding, Denmark; Lameyre, V., Sanofi, Access to Medicines, Paris, France; Lee, S.J., Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Lell, B., Institute for Tropical Medicine, University of Tubingen, Tubingen, Germany, Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon; Lima, N., Médecins Sans Frontières, Operational Centre Barcelona Athens, Barcelona, Spain; Marsh, K., Kenya Medical Research Institute, Wellcome Trust Research Programme, Kilifi, Kenya, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Mårtensson, A., Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden, Department of Women's and Children's Health, International Maternal and Child Health (IMCH), Upssala University, Uppsala, Sweden; Massougbodji, A., Centre d'Etudes et de Recherche sur le Paludisme Associe a la Grossesse et a l'Enfant (CERPAGE), Faculté des Sciences de la Santé (FSS), Université d'Abomey-Calavi, Cotonou, Benin; Mayxay, M., Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom, Lao-Oxford-Mahosot Hospital, Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Laos, Faculty of Postgraduate Studies, University of Health Sciences, Vientiane, Laos; McGready, R., Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Menan, H., Department of Parasitology, Faculty of Pharmacy, University of Cocody, Abidjan, Cote d'Ivoire; Menendez, C., Barcelona Institute for Global Health (ISGlobal), Hospital Clinic, University of Barcelona, Spain, CISM, Manhiça Health Research Center, Manhiça, Mozambique; Mens, P., Royal Tropical Institute, KIT Biomedical Research, Amsterdam, Netherlands, Division of Infectious Diseases, Center for Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Netherlands; Meremikwu, M., Department of Paediatrics, University of Calabar, Nigeria Institute of Tropical Diseases Research and Prevention, Calabar, Nigeria; Mockenhaupt, F.P., Institute of Tropical Medicine and International Health, Charite-Universitatsmedizin Berlin, Germany; Moreira, C., WWARN, Oxford, United Kingdom, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Nabasumba, C., Epicentre, Paris, France, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda; Nambozi, M., Tropical Diseases Research Centre, Ndola, Zambia; Ndiaye, J.-L., Parasitology and Mycology Laboratory, Medical Faculty, Université Cheikh Anta Diop, Dakar, Senegal; Newton, P.N., Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom, Lao-Oxford-Mahosot Hospital, Wellcome Trust Research Unit, Mahosot Hospital, Vientiane, Laos; Ngasala, B.E., Department of Parasitology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania, Malaria Research, Infectious Disease Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden; Nosten, F., Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Nsanzabana, C., Epicentre, Paris, France, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Offianan, A.T., Malariology Department, Institut Pasteur, Abidjan, Cote d'Ivoire; Oguike, M., Department of Immunology and Infection, LSHTM, London, United Kingdom; Ogutu, B.R., Kenya Medical Research Institute, United States Army Medical Research Unit, Kisumu, Kenya; Olliaro, P., UNICEF/UNDP/World Bank, WHO Special Programme for Research and Training in Tropical Diseases (WHO/TDR), Geneva, Switzerland; Omar, S.A., International Centre for Insect Physiology and Ecology (ICIPE), Mbita Point, Kenya; Osorio, L., Facultad de Salud, Universidad del Valle, Cali, Colombia; Owusu-Agyei, S., Kintampo Health Research Centre, Kintampo, Ghana; Penali, L.K., WWARN, Dakar, Senegal; Pene, M., Department of Medical Parasitology, Medical Faculty, Université Cheikh Anta Diop, Dakar, Senegal; Peshu, J., Kenya Medical Research Institute, Wellcome Trust Research Programme, Kilifi, Kenya; Piola, P., Institut Pasteur de Madagascar, Antananarivo, Madagascar; Premji, Z., Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Price, R.N., WWARN, Oxford, United Kingdom, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom, Menzies School of Health Research, Charles Darwin University, Darwin, Australia; Ramharter, M., Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University Vienna, Austria, Institut für Tropenmedizin, Universität Tübingen, Germany, Centre de Recherches Medicales de Lambaréné, Gabon; Rombo, L., Infectious Diseases Unit, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden; Roper, C., LSHTM, London, United Kingdom; Rosenthal, P.J., Department of Medicine, University of California San Francisco, San Francisco, United States; Sagara, I., Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto-Stomatology, University of Bamako, Bamako, Mali; Sawa, P., Human Health Division, International Centre for Insect Physiology and Ecology, Mbita, Kenya; Schallig, H.D.F.H., Royal Tropical Institute, KIT Biomedical Research, Amsterdam, Netherlands; Schramm, B., Epicentre, Paris, France; Shekalaghe, S.A., Ifakara Health Institute, Bagamoyo, Tanzania; Sibley, C.H., WWARN, Oxford, United Kingdom, Department of Genome Sciences, University of Washington, Seattle, United States; Sirima, S., Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso; Smithuis, F., Myanmar Oxford Clinical Research Unit (MOCRU), Yangon, Myanmar, Medical Action Myanmar, Yangon, Myanmar; Sow, D., Service de Parasitologie, Medical Faculty, Université Cheikh Anta Diop, Dakar, Senegal; Staedke, S.G., Department of Clinical Research, LSHTM, London, United Kingdom, Infectious Disease Research Collaboration, Kampala, Uganda; Stepniewska, K., WWARN, Oxford, United Kingdom, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Sutanto, I., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sutherland, C.J., Department of Immunology and Infection, LSHTM, London, United Kingdom; Swarthout, T.D., Médecins Sans Frontières, London, United Kingdom; Syafruddin, D., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Sylla, K., Service de Parasitologie-Mycologie Médicale, Université Cheikh Anta Diop, Dakar, Senegal; Talisuna, A.O., University of Oxford, KEMRI, Wellcome Trust Research Programme, Nairobi, Kenya; Taylor, W.R., Institute for Biomechanics, Department of Health Science and Technology, Eidgenössische Technische Hochschule Zürich, Zürich, Switzerland; Temu, E.A., MENTOR Initiative, Crawley, United Kingdom, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland; Kuile, F.T., Liverpool School of Tropical Medicine, Liverpool, United Kingdom, Kenya Medical Research Institute (KEMRI), Centre for Global Health Research, Kisumu, Kenya; Tinto, H., Institut de Recherce en Sciences de la Sante, Bobo Dioulasso, Burkina Faso, Centre Muraz, Bobo Dioulasso, Burkina Faso; Tjitra, E., National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Ursing, J., Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden, Projecto de Saúde de Bandim, Indepth Network, Bissau, Guinea-Bissau; Valecha, N., National Institute of Malaria Research, New Delhi, India; Van Den Broek, I., Médecins Sans Frontières, London, United Kingdom, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands; Van Herp, M., Médecins Sans Frontières, Operational Centre Brussels, Brussels, Belgium; Van Vugt, M., Royal Tropical Institute, KIT Biomedical Research, Amsterdam, Netherlands; Ward, S.A., Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; White, N.J., Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Winstanley, P.A., School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom; Woodrow, C.J., Mahidol Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Yeka, A., Uganda Malaria Surveillance Project, Kampala, Uganda; Zwang, J., Health Services Research Unit, Lillebaelt Hospital, IRS University of Southern Denmark, Vejle, Denmark; WWARN Gametocyte Study Group
Background: Gametocytes are responsible for transmission of malaria from human to mosquito. Artemisinin combination therapy (ACT) reduces post-treatment gametocyte carriage, dependent upon host, parasite and pharmacodynamic factors. The gametocytocidal properties of antimalarial drugs are important for malaria elimination efforts. An individual patient clinical data meta-analysis was undertaken to identify the determinants of gametocyte carriage and the comparative effects of four ACTs: artemether-lumefantrine (AL), artesunate/amodiaquine (AS-AQ), artesunate/mefloquine (AS-MQ), and dihydroartemisinin-piperaquine (DP). Methods: Factors associated with gametocytaemia prior to, and following, ACT treatment were identified in multivariable logistic or Cox regression analysis with random effects. All relevant studies were identified through a systematic review of PubMed. Risk of bias was evaluated based on study design, methodology, and missing data. Results: The systematic review identified 169 published and 9 unpublished studies, 126 of which were shared with the WorldWide Antimalarial Resistance Network (WWARN) and 121 trials including 48,840 patients were included in the analysis. Prevalence of gametocytaemia by microscopy at enrolment was 12.1 % (5887/48,589), and increased with decreasing age, decreasing asexual parasite density and decreasing haemoglobin concentration, and was higher in patients without fever at presentation. After ACT treatment, gametocytaemia appeared in 1.9 % (95 % CI, 1.7-2.1) of patients. The appearance of gametocytaemia was lowest after AS-MQ and AL and significantly higher after DP (adjusted hazard ratio (AHR), 2.03; 95 % CI, 1.24-3.12; P = 0.005 compared to AL) and AS-AQ fixed dose combination (FDC) (AHR, 4.01; 95 % CI, 2.40-6.72; P < 0.001 compared to AL). Among individuals who had gametocytaemia before treatment, gametocytaemia clearance was significantly faster with AS-MQ (AHR, 1.26; 95 % CI, 1.00-1.60; P = 0.054) and slower with DP (AHR, 0.74; 95 % CI, 0.63-0.88; P = 0.001) compared to AL. Both recrudescent (adjusted odds ratio (AOR), 9.05; 95 % CI, 3.74-21.90; P < 0.001) and new (AOR, 3.03; 95 % CI, 1.66-5.54; P < 0.001) infections with asexual-stage parasites were strongly associated with development of gametocytaemia after day 7. Conclusions: AS-MQ and AL are more effective than DP and AS-AQ FDC in preventing gametocytaemia shortly after treatment, suggesting that the non-artemisinin partner drug or the timing of artemisinin dosing are important determinants of post-treatment gametocyte dynamics. © 2016 WWARN Gametocyte Study Group.
Drug resistance; Gametocyte; Malaria; Plasmodium falciparum
amodiaquine plus artesunate; artemether plus benflumetol; artemisinin; artesunate plus mefloquine; dihydroartemisinin plus piperaquine; hemoglobin; Africa; age; anemia; Article; asexual reproduction; Asia; child; controlled study; disease transmission; female; fever; gametocytaemia; gametocyte; hazard ratio; hematocrit; human; leukocyte count; major clinical study; malaria falciparum; male; meta analysis; microscopy; mixed infection; parasite clearance; parasitemia; prevalence; reinfection; risk factor; sensitivity analysis; South America; systematic review; temperature; treatment response; underweight
Medical Research Council
BioMed Central Ltd.
17417015
27221542
Article
Q1
4046
412