Publikasi Scopus 2010 s/d 2022

5382

Authors_(Last_Name)

Zhou J., Sirisanthana T., Kiertiburanakul S., Chen Y.-M.A., Han N., Lim P.-L., Kumarasamy N., Choi J.Y., Merati T.P., Yunihastuti E., Oka S., Kamarulzaman A., Phanuphak P., Lee C.K.C., Li P.C.K., Pujari S., Saphonn V., Law M.G.

Author S Id

55261984900;7004277229;6506539792;18533914400;57206253688;10041498300;7003549856;57791298700;8935806500;57221273925;57202558648;6603019663;7004982661;56927096300;36068280500;57205894660;6506943093;55556254800;

Title

Trends in CD4 counts in HIV-infected patients with HIV viral load monitoring while on combination antiretroviral treatment: Results from The TREAT Asia HIV Observational Database

Year

2010

Source Title

BMC Infectious Diseases

Volume

Issue

Art No

361

Page Start

Page End

Page Count

Cited By

Link

https://www.scopus.com/inward/record.uri?eid=2-s2.0-78651492845&doi=10.1186%2f1471-2334-10-361&partnerID=40&md5=06cdd9783ba23ff62eb1e93ba5f07f69

Affiliations

National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, Australia; Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand; Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Taipei Veterans General Hospital and AIDS Prevention and Research Centre, National Yang-Ming University, Taipei, Taiwan; Beijing Ditan Hospital, Beijing, China; Tan Tock Seng Hospital, Singapore; YRG Centre for AIDS Research and Education, Chennai, India; Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, South Korea; School of Medicine Udayana University and Sanglah Hospital, Denpasar, Bali, Indonesia; Working Group on AIDS Faculty of Medicine, University of Indonesia/Ciptomangunkusumo Hospital, Jakarta, Indonesia; International Medical Centre of Japan, Tokyo, Japan; University of Malaya Medical Centre, Kuala Lumpur, Malaysia; HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Hospital Sungai Buloh, Kuala Lumpur, Malaysia; Queen Elizabeth Hospital, Hong Kong, China; Institute of Infectious Diseases, Pune, India; National Center for HIV/AIDS, Dermatology and STDs, Phnom Penh, Cambodia

Authors With Affiliations

Zhou, J., National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, Australia; Sirisanthana, T., Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand; Kiertiburanakul, S., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Chen, Y.-M.A., Taipei Veterans General Hospital and AIDS Prevention and Research Centre, National Yang-Ming University, Taipei, Taiwan; Han, N., Beijing Ditan Hospital, Beijing, China; Lim, P.-L., Tan Tock Seng Hospital, Singapore; Kumarasamy, N., YRG Centre for AIDS Research and Education, Chennai, India; Choi, J.Y., Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, South Korea; Merati, T.P., School of Medicine Udayana University and Sanglah Hospital, Denpasar, Bali, Indonesia; Yunihastuti, E., Working Group on AIDS Faculty of Medicine, University of Indonesia/Ciptomangunkusumo Hospital, Jakarta, Indonesia; Oka, S., International Medical Centre of Japan, Tokyo, Japan; Kamarulzaman, A., University of Malaya Medical Centre, Kuala Lumpur, Malaysia; Phanuphak, P., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Lee, C.K.C., Hospital Sungai Buloh, Kuala Lumpur, Malaysia; Li, P.C.K., Queen Elizabeth Hospital, Hong Kong, China; Pujari, S., Institute of Infectious Diseases, Pune, India; Saphonn, V., National Center for HIV/AIDS, Dermatology and STDs, Phnom Penh, Cambodia; Law, M.G., National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, Australia

Abstract

Background: The aim of this study was to examine the relationship between trends in CD4 counts (slope) and HIV viral load (VL) after initiation of combination antiretroviral treatment (cART) in Asian patients in The TREAT Asia HIV Observational Database (TAHOD).Methods: Treatment-naive HIV-infected patients who started cART with three or more and had three or more CD4 count and HIV VL tests were included. CD4 count slopes were expressed as changes of cells per microliter per year. Predictors of CD4 count slopes from 6 months after initiation were assessed by random-effects linear regression models.Results: A total of 1676 patients (74% male) were included. The median time on cART was 4.2 years (IQR 2.5-5.8 years). In the final model, CD4 count slope was associated with age, concurrent HIV VL and CD4 count, disease stage, hepatitis B or C co-infection, and time since cART initiation. CD4 count continues to increase with HIV VL up to 20 000 copies/mL during 6-12 months after cART initiation. However, the HIV VL has to be controlled below 5 000, 4 000 and 500 copies/mL for the CD4 count slope to remain above 20 cells/microliter per year during 12-18, 18-24, and beyond 24 months after cART initiation.Conclusions: After cART initiation, CD4 counts continued to increase even when the concurrent HIV VL was detectable. However, HIV VL needed to be controlled at a lower level to maintain a positive CD4 count slope when cART continues. The effect on long-term outcomes through the possible development of HIV drug resistance remains uncertain. © 2010 Zhou et al; licensee BioMed Central Ltd.

Author Keywords

Index Keywords

antiretrovirus agent; atazanavir; efavirenz plus lamivudine plus stavudine; efavirenz plus lamivudine plus zidovudine; indinavir; lamivudine plus nevirapine plus stavudine; lamivudine plus nevirapine plus zidovudine; lopinavir; nelfinavir; saquinavir; unclassified drug; adult; age distribution; article; CD4 lymphocyte count; concurrent infection; controlled study; data base; disease classification; female; hepatitis B; hepatitis C; HIV test; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; major clinical study; male; mixed infection; treatment duration; trend study; virus load; Asia; clinical trial; highly active antiretroviral therapy; Human immunodeficiency virus infection; immunology; multicenter study; statistical model; virology; Adult; Ant

Funding Details

National Institutes of Health; National Institute of Allergy and Infectious Diseases; amfAR, The Foundation for AIDS Research; Department of Health and Ageing, Australian Government; University of New South Wales; Ministerie van Buitenlandse Zaken

Funding Text 1

The TREAT Asia HIV Observational Database is part of the Asia Pacific HIV Observational Database and is an initiative of TREAT Asia, a program of amfAR, The Foundation for AIDS Research, with support from the National Institute of Allergy and Infectious Diseases (NIAID) of the U.S. National Institutes of Health (NIH) as part of the International Epidemiologic Databases to Evaluate AIDS (IeDEA) (gr

Funding Text 2

Funding Text 3

Publisher

Issn

14712334

Isbn

Pubmed Id

21182796

Document Type

Article

Sjr Best Quartile

Sjr

1441

Sjr Rank

2076