Publikasi Scopus 2010 s/d 2022

Authors_(Last_Name)

Bowolaksono A., Sundari A.M., Fauzi M., Maidarti M., Wiweko B., Mutia K., Iffanolida P.A., Febri R.R., Dwiranti A., Funahashi H.

Author S Id

57205093224;57222070793;57211523956;56320510400;43061741400;57195936432;57195937128;57195941864;55151437900;7101693144;

Title

Anti-Müllerian hormone independently affect mtDNA copy number in human granulosa cells

Year

2022

Source Title

Journal of Ovarian Research

Volume

Issue

Art No

111

Page Start

Page End

Page Count

Cited By

Link

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85139741289&doi=10.1186%2fs13048-022-01047-4&partnerID=40&md5=a1bfe0b6b1eb157945ff14b80dd42874

Affiliations

Cellular and Molecular Mechanisms in Biological System (CEMBIOS) Research Group, Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus FMIPA UI, Depok, 16424, Indonesia; Indonesian Reproductive Science Institute (IRSI) Research and Training Center, Jakarta, Indonesia; Department of Diabetes, Endocrinology, and Clinical Nutrition, Graduates School of Medicine, Kyoto University, Kyoto, Japan; Human Reproductive, Infertility, and Family Planning (HRIFP) Research Center, Indonesian Medical Education and Research Institutes, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Graduate School of Natural Science and Technology, Okayama University, Tsushima-Naka, Kita-ku, Okayama, 700-8530, Japan

Authors With Affiliations

Bowolaksono, A., Cellular and Molecular Mechanisms in Biological System (CEMBIOS) Research Group, Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus FMIPA UI, Depok, 16424, Indonesia; Sundari, A.M., Cellular and Molecular Mechanisms in Biological System (CEMBIOS) Research Group, Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus FMIPA UI, Depok, 16424, Indonesia, Indonesian Reproductive Science Institute (IRSI) Research and Training Center, Jakarta, Indonesia; Fauzi, M., Cellular and Molecular Mechanisms in Biological System (CEMBIOS) Research Group, Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus FMIPA UI, Depok, 16424, Indonesia, Department of Diabetes, Endocrinology, and Clinical Nutrition, Graduates School of Medicine, Kyoto University, Kyoto, Japan; Maidarti, M., Human Reproductive, Infertility, and Family Planning (HRIFP) Research Center, Indonesian Medical Education and Research Institutes, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiweko, B., Human Reproductive, Infertility, and Family Planning (HRIFP) Research Center, Indonesian Medical Education and Research Institutes, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mutia, K., Human Reproductive, Infertility, and Family Planning (HRIFP) Research Center, Indonesian Medical Education and Research Institutes, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Iffanolida, P.A., Human Reproductive, Infertility, and Family Planning (HRIFP) Research Center, Indonesian Medical Education and Research Institutes, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Febri, R.R., Human Reproductive, Infertility, and Family Planning (HRIFP) Research Center, Indonesian Medical Education and Research Institutes, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dwiranti, A., Cellular and Molecular Mechanisms in Biological System (CEMBIOS) Research Group, Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus FMIPA UI, Depok, 16424, Indonesia; Funahashi, H., Graduate School of Natural Science and Technology, Okayama University, Tsushima-Naka, Kita-ku, Okayama, 700-8530, Japan

Abstract

Background:: Recently, as a delayed childbearing trend is emerging in modern women’s adulthood, diminished reproductive potential due to age-related changes is more prevalent. Reduction in the abundance of mitochondrial DNA (mtDNA) copies and circulating anti-Müllerian hormone (AMH) have been separately reported with aging, contributing to the decrease in successful reproduction. However, there are limited reports on the impact of age on mtDNA and AMH in the same individual and whether mtDNA copy numbers are influenced by age and AMH. Methods:: In the present study, we utilized a real-time quantitative PCR (RT-qPCR) to quantify the mtDNA copy number of granulosa cells obtained from 43 women undergoing an in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) program. Results:: According to our analysis, a significant correlation was observed between age and mtDNA copy number (r = −0.54, P < 0.001) and between age and AMH level (r = −0.48, P < 0.001) of the same individual. There was also a positive correlation between mtDNA copy number and AMH (r = 0.88, P < 0.001) with AMH level falling as mtDNA decreases. In our regression, age and AMH were shown to have low collinearity (VIF = 1.297) but only AMH was correlated with mtDNA quantity (P < 0.001). Conclusion:: Our study suggests that both mtDNA and AMH abundance are influenced by age and that AMH levels independently affect mtDNA copy number regardless of age. Further research is required to understand the role of AMH on mitochondria bioenergetics. © 2022, The Author(s).

Author Keywords

Aging; Anti-Müllerian hormone; Fertility; Granulosa cells; Mitochondrial DNA (mtDNA)

Index Keywords

growth hormone; luteinizing hormone; mitochondrial DNA; Muellerian inhibiting factor; mitochondrial DNA; Muellerian inhibiting factor; transforming growth factor beta; age distribution; Article; bioenergy; body mass; body weight; clinical article; copy number variation; correlation analysis; embryo; embryo transfer; female; female infertility; granulosa cell; hormone action; hormone determination; human; human cell; human tissue; in vitro fertilization; intracytoplasmic sperm injection; real time polymerase chain reaction; adult; copy number variation; genetics; granulosa cell; male; metabolism; mitochondrion; sperm; Adult; Anti-Mullerian Hormone; DNA Copy Number Variations; DNA, Mitochondrial; Female; Fertilization in Vitro; Granulosa Cells; Humans; Male; Mitochondria; Semen; Transforming

Funding Details

Universitas Indonesia; Fakultas Farmasi, Universitas Indonesia

Funding Text 1

This research was funded by the Directorate of Research and Community Service, University of Indonesia through Hibah Penugasan Penelitian Kemitraan Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi Grant (NKB-979/UN2.RST/HKP.05.00/2022).

Funding Text 2

Funding Text 3

Publisher

BioMed Central Ltd

Issn

17572215

Isbn

Pubmed Id

36224631

Document Type

Article

Sjr Best Quartile

Sjr

1019

Sjr Rank

3977