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763 |
Gunardi W.D., Timotius K.H., Natasha A., Evriarti P.R. |
57222314683;24299781600;57211428938;57226004232; |
Biofilm targeting strategy in the eradication of burkholderia infections: A mini-review |
2021 |
Open Microbiology Journal |
15 |
1 |
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51 |
57 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110074931&doi=10.2174%2f1874285802115010051&partnerID=40&md5=70632c812ea82598129daf4afdd465df |
Department of Microbiology, Faculty of Medicine, Krida Wacana Christian University (UKRIDA), Jakarta, Indonesia; Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Microbiolgy, Health Labortory of Makassar (BBLK Makassar), Makassar, Indonesia |
Gunardi, W.D., Department of Microbiology, Faculty of Medicine, Krida Wacana Christian University (UKRIDA), Jakarta, Indonesia; Timotius, K.H., Department of Microbiology, Faculty of Medicine, Krida Wacana Christian University (UKRIDA), Jakarta, Indonesia; Natasha, A., Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Evriarti, P.R., Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Microbiolgy, Health Labortory of Makassar (BBLK Makassar), Makassar, Indonesia |
Burkholderia are intracellular pathogenic bacteria which can produce biofilm. This biofilm protects the intracellular pathogenic bacteria from antibiotic treatment and the immunological system of the host. Therefore, this review aims to describe the capacity of Burkholderia to form a biofilm, the regulation of its biofilm formation, the efficacy of antibiotics to eradicate biofilm, and the novel therapy which targets its biofilm. Burkholderia's biofilm is characterized by its lipopolysaccharides, exopolysaccharides (EPSs), biofilm-associated proteins, and eDNA. Its regulation is made by quorum sensing, c-di-AMP, sRNA, and two component systems. Many antibiotics have been used as sole or mixture agents; however, they are not always effective in eradicating the biofilm-forming Burkholderia. Inhibitors of quorum sensing and other non-conventional antibiotic approaches are promising to discover effective treatment of Burkholderia infections. © 2021, Bentham Science Publishers. All rights reserved. |
Antibiotic; Biofilm; Burkholderia; Exopolysaccharide; Lipid A; Quorum sensing |
acetazolamide; amoxicillin; antibiotic agent; cefepime; ceftazidime; colistin; echinocandin; exopolysaccharide; gentamicin; imipenem; indisulam; lipopolysaccharide; macrolide; meropenem; piperacillin plus tazobactam; polymyxin B; RANTES; saccharin; sulpiride; tobramycin; topiramate; transcriptome; vancomycin; virulence factor; Acinetobacter baumannii; antibiofilm activity; antibiotic resistance; antibiotic sensitivity; antibiotic therapy; apoptosis; Article; autolysis; bacteremia; bacterial arthritis; bacterial colonization; bacterial gene; bacterial growth; bacterial virulence; Betaproteobacteria; biofilm; Burkholderia cenocepacia; Burkholderia infection; Burkholderia pseudomallei; cell aggregation; DNA damage; Enterococcus faecalis; extracellular matrix; gene; gene expression; Helicobact |
Bentham Science Publishers |
18742858 |
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Article |
Q3 |
502 |
10043 |
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764 |
Yulia D.E., Kurnia K.H., Mahyuddin M., Edwar L., Amanda L. |
57225947931;57222405280;57225946039;55695047800;57225929959; |
Successful Management of a Rare Paediatric Orbital Subperiosteal Abscess: A Case Report |
2021 |
African Vision and Eye Health |
80 |
1 |
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1 |
3 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109939244&doi=10.4102%2fAVEH.V80I1.631&partnerID=40&md5=ad4fc29a3f5162b1ce2a0a28e7eafe79 |
Department of Ophthalmology, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Yulia, D.E., Department of Ophthalmology, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Kurnia, K.H., Department of Ophthalmology, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Mahyuddin, M., Department of Ophthalmology, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Edwar, L., Department of Ophthalmology, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Amanda, L., Department of Ophthalmology, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Paediatric orbital subperiosteal abscess (SPA) requires prompt and appropriate treatment to prevent further complication. A 10-year-old girl with a history of sinusitis came with progressive swelling on her left eye, non-axial proptosis and visual acuity (VA) was 2/60. A computed tomography scan revealed a SPA formation in the superior left orbit. This report highlights that intravenous antibiotic with incision and drainage surgery improved the VA with resolution of proptosis and swelling. © 2021. The Author(s). Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License. |
antibiotic administration; incision and drainage; non-axial proptosis; orbital infection; paediatric subperiosteal abscess |
amoxicillin; antibiotic agent; ceftriaxone; methylprednisolone; metronidazole; Article; case report; child; clinical article; computer assisted tomography; endoscopic sinus surgery; exophthalmos; eye pain; eye swelling; female; follow up; human; intraocular pressure; orbit infection; orbital subperiosteal abscess; visual acuity |
AOSIS (pty) Ltd |
24133183 |
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Article |
Q4 |
186 |
20274 |
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766 |
Dharma S., Dakota I., Andriantoro H., Firdaus I., Gunawan Limadhy I., Van De Werf F. |
55101301700;55796663700;55037171500;55796864700;57225219360;36048879600; |
Trends in reperfusion therapy for acute ST-segment elevation myocardial infarction in an academic percutaneous coronary intervention center in the metropolitan area of a developing country: Insights from the Jakarta Acute Coronary Syndrome registry |
2021 |
Coronary Artery Disease |
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466 |
467 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109587625&doi=10.1097%2fMCA.0000000000000939&partnerID=40&md5=a4f6e1151d84a687c4d99a6b1f8480c6 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jl S Parman Kav 87, Slipi, Jakarta Barat, Jakarta, 11420, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Indonesia; Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium |
Dharma, S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jl S Parman Kav 87, Slipi, Jakarta Barat, Jakarta, 11420, Indonesia; Dakota, I., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Indonesia; Andriantoro, H., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Indonesia; Firdaus, I., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Indonesia; Gunawan Limadhy, I., Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Van De Werf, F., Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium |
[No abstract available] |
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adverse event; causality; epidemiology; female; fibrinolytic therapy; heart muscle reperfusion; hospital mortality; human; Indonesia; male; middle aged; mortality; organization and management; percutaneous coronary intervention; preventive health service; procedures; register; ST segment elevation myocardial infarction; time to treatment; total quality management; Causality; Female; Hospital Mortality; Humans; Indonesia; Male; Middle Aged; Myocardial Reperfusion; Percutaneous Coronary Intervention; Preventive Health Services; Quality Improvement; Registries; ST Elevation Myocardial Infarction; Thrombolytic Therapy; Time-to-Treatment |
Lippincott Williams and Wilkins |
09546928 |
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32804781 |
Article |
Q3 |
504 |
10001 |
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771 |
Victor A.A., Violetta L., Kusumowidagdo G., Pranata R. |
57191055282;57216555090;57200641034;57201973901; |
Pars-plana vitrectomy combined with retinectomy in severe open-globe injuries: A systematic review and meta-analysis |
2021 |
European Journal of Ophthalmology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109102924&doi=10.1177%2f11206721211029472&partnerID=40&md5=864797e21da1505f0aa16812f4da115e |
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Zhejiang University School of Medicine, Hangzhou, China; Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia |
Victor, A.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Violetta, L., Zhejiang University School of Medicine, Hangzhou, China, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia; Kusumowidagdo, G., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia |
Background: This review summarized prophylactic retinectomy technique and its effect on anatomic and functional outcomes in severe open globe injuries (OGIs). Methods: A comprehensive search in PubMed (MEDLINE), Embase, Scopus, and EuropePMC databases was performed up until 8 January 2020. Enrolled studies include case series, studies involving pars plana vitrectomy (PPV) combined with retinectomy in severe penetrating injuries with or without IOFB, perforating injuries, and globe ruptures. Primary outcome was best-corrected visual acuity (BCVA) ⩾20/200 at the end of the study. Secondary outcomes were the rate of proliferative retinopathy (PVR), globe survival rate and retinal reattachment rate. Results: A total of seven studies, involving 275 eyes with severe OGIs, is included in this study. Meta-analysis indicates that final BCVA ⩾20/200 was achieved in 61% (95% CI 49%–73%). Meta-regression analysis showed that improvement was inversely affected by the presence of pre-operative direct macular injury (p = 0.001) and corneal scar (p = 0.015). The proportion of pre-operative BCVA <20/200 was statistically insignificant to the final BCVA ⩾20/200 (p = 0.569). One study showed that the rate is higher in the retinectomy group than the non-retinectomy group (54% vs 11%). Meta-analysis showed that anatomical success can be achieved in 85% (95% CI 78%–91%) of the patients. Meta-regression analysis indicates that the anatomical success did not vary with age (p = 0.653), retinal detachment (p = 0.525), corneal scar (p = 0.596), and lens involvement (p = 0.450). Conclusion: Early PPV combined with retinectomy was associated with acceptable visual improvement and anatomical success. © The Author(s) 2021. |
eye injuries; open-globe injuries; proliferative vitreoretinopathy; Retinectomy; vitrectomy |
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SAGE Publications Ltd |
11206721 |
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Article |
Q2 |
790 |
6120 |
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772 |
Maryam R.S., Sahar J., Hastono S.P., Harimurti K. |
57209730009;6508226729;57211434645;23473513200; |
Common symptoms of alzheimer’s dementia that are easily recognizable by families [Sintomas comuns da demência de alzheimer facilmente reconhecíveis pelas famílias] |
2021 |
Dementia e Neuropsychologia |
15 |
2 |
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186 |
191 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109080999&doi=10.1590%2f1980-57642021dn15-020005&partnerID=40&md5=7d8636011b9ebdb60c6dd608e999cc16 |
Faculty of Nursing, Universitas Indonesia, Jawa Barat, Indonesia; Faculty of Medicine, Universitas Indonesia, Jawa Barat, Indonesia; Faculty of Public Health, Universitas Indonesia, Jawa Barat, Indonesia |
Maryam, R.S., Faculty of Nursing, Universitas Indonesia, Jawa Barat, Indonesia; Sahar, J., Faculty of Nursing, Universitas Indonesia, Jawa Barat, Indonesia; Hastono, S.P., Faculty of Medicine, Universitas Indonesia, Jawa Barat, Indonesia; Harimurti, K., Faculty of Public Health, Universitas Indonesia, Jawa Barat, Indonesia |
The increase in dementia incidence among the elderly is directly related to aging, which is associated with changes in bodily functions and other health-related risk factors. Alzheimer’s dementia is the most prevalent form of dementia, and individuals in the late stages are predominantly dependent on other family members. Therefore, it is important for families, as the closest support group, to recognize common symptoms early. Objective: To provide a family-friendly guide to the ten common symptoms of Alzheimer’s dementia. Methods: This is a descriptive survey-based research that included 354 families comprising elderly people (≥60 years) residing in Jakarta. The instrument aimed at identifying ten common Alzheimer’s dementia symptoms in Indonesia. Descriptive statistical analysis based on frequency tables was used. Results: The participant’s major characteristics were age ≥66 years (52.3%), female sex (70.3%) and primary school education (87.3%). The predominant symptoms experienced by 42.4% of the elderly included forgetting recent events and asking questions and narrating a particular detail repeatedly. The remaining 35.6% demonstrated signs of forgetting where an item was placed and frequently suspecting others of theft and concealment of personal items. Conclusion: The symptoms of frequently forgetting new events and the location of personal belongings are of particular concern for families, as they have a propensity to progress and interfere with daily activities. Therefore, the families of affected individuals are expected to identify this symptom early on and present the affected individual for screening or examination at a health care facility. © 2021, Associacao Arquivos de Neuro-Psiquiatria. All rights reserved. |
Alzheimer disease; Dementia; Family; Memory disorders |
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Associacao Arquivos de Neuro-Psiquiatria |
19805764 |
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Article |
Q3 |
540 |
9365 |
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774 |
Atmakusuma T.D., Girson R., Koesnoe S. |
57216961785;14324834100;26028015000; |
Correlations between Iron Load and CD4 in Adult Transfusion-Dependent Beta Thalassemia |
2021 |
Anemia |
2021 |
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5549503 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108909049&doi=10.1155%2f2021%2f5549503&partnerID=40&md5=86934d2b70e3a64770f20d2512ea4dfb |
Division of Hematology-Medical Oncology, Department of Internal Medicine Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia; Division of Allergy-Immunology, Department of Internal Medicine. Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia; Girson, R., Division of Hematology-Medical Oncology, Department of Internal Medicine Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia; Koesnoe, S., Division of Allergy-Immunology, Department of Internal Medicine. Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia |
Background. Thalassemia is a hereditary disease, and severe anemia is the main phenotype of major thalassemia. Furthermore, the most important method in the management of this disease is red blood cell transfusion. Regular transfusions administered 1 or 2 times every month improve prognosis and survival. However, there is higher risk of infections and iron overload, especially in transfusion-dependent thalassemia (TDT). Infections are the second leading cause of death in adult TDT, after heart failure. Higher risk of infection is also influenced by multiple blood transfusions which causes alteration in immune response due to alloimmunization, transfusion-related infections, and iron overload. Meanwhile, iron overload in TDT alters both innate and specific immune responses. Furthermore, previous studies have shown the correlation between ferritin with CD4, but this has not been carried out in Indonesia. Therefore, this study aims to determine the correlations between iron overload (serum ferritin and transferrin saturation) and specific immune cells (CD4). Methods. This is a cross-sectional study, and a total number of 64 subjects were examined consecutively. Chest X-ray and blood sera were obtained. The total number of subjects was 64. The seromarkers HBsAg, anti-HCV, and anti-HIV were tested using the ELISA method. Serum ferritin and transferrin saturation was tested using ECLIA, and lymphocyte subsets were analyzed using flowcytometry. Meanwhile, the correlation between variables was determined using Spearman's test. Results. The results showed that 4.9% subjects were HBsAg positive, 10.7% were anti-HCV positive, and none were anti-HIV positive. There were 4 subjects with lung tuberculosis based on the 41 chest X-ray. Meanwhile, there was a weak negative and insignificant correlation between serum ferritin with CD4 (p=0.75; r = -0.04) and a weak positive and insignificant correlation between transferrin saturation with CD4 (p=0.133; r = 0.19). Conclusion. There were no correlations between iron overload (ferritin) and cellular immunity (CD4) in adult transfusion-dependent thalassemia. © 2021 Tubagus Djumhana Atmakusuma et al. |
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C reactive protein; ferritin; hemoglobin; hepatitis B surface antigen; hepatitis C antibody; Human immunodeficiency virus antibody; iron chelating agent; transferrin; tuberculostatic agent; adult; antibiotic therapy; antibody detection; antigen detection; Article; beta thalassemia; blood sampling; blood transfusion; CD4 lymphocyte count; cellular immunity; chronic hepatitis; coinfection; cross-sectional study; disease association; electrochemiluminescence immunoassay; enzyme linked immunosorbent assay; facies; female; ferritin blood level; flow cytometry; hemoglobin blood level; hemoglobin E-beta thalassemia; hepatitis B; hepatitis C; human; human cell; Human immunodeficiency virus infection; iron overload; leukocyte count; lung tuberculosis; lymphocyte subpopulation; major clinical study; |
Hindawi Limited |
20901267 |
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Article |
Q2 |
921 |
4948 |
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775 |
Estiasari R., Diwyacitta A., Sidik M., Rida Ariarini N.N., Sitorus F., Marwadhani S.S., Maharani K., Imran D., Arpandy R.A., Pangeran D., Hakim M. |
55240204000;57225009324;56252760000;57225009527;57208331594;57203760168;57189235094;57203976849;49361070700;57203764449;57216861859; |
Evaluation of Retinal Structure and Optic Nerve Function Changes in Multiple Sclerosis: Longitudinal Study with 1-Year Follow-Up |
2021 |
Neurology Research International |
2021 |
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5573839 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108905101&doi=10.1155%2f2021%2f5573839&partnerID=40&md5=7aaf49b7f8adca76fa739b0330ba1aff |
Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Ophtalmology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Estiasari, R., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Diwyacitta, A., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Sidik, M., Department of Ophtalmology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Rida Ariarini, N.N., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Sitorus, F., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Marwadhani, S.S., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Maharani, K., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Imran, D., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Arpandy, R.A., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Pangeran, D., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Hakim, M., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Background. Multiple sclerosis (MS) is an autoimmune disease characterized by inflammation and demyelination of the central nervous system which often involves the optic nerve even though only 20% of the patients experience optic neuritis (ON). Objective. This study aims to compare the retinal structure and optic nerve function between patients with MS and healthy controls (HCs), evaluate optic nerve alterations in MS over 1-year follow-up, and analyze its correlations with disease duration, number of relapses, degree of disability, and different subtypes. Methods. This is a prospective cohort study involving 58 eyes of MS patients. Optic nerve function was evaluated with best-corrected visual acuity (BCVA), contrast sensitivity, and P100 latency, while the retinal structure was evaluated from the GCIPL and RNFL thickness measured with optical coherence tomography (OCT) and fundus photography. Results. The MS group had lower BCVA (p=0.001), contrast sensitivity (p<0.001), mean GCIPL thickness (p<0.001), and mean RNFL thickness (p<0.001) than HC. At 6 and 12 months of observations, GCIPL and RNFL (nasal quadrant) of MS patients decreased significantly (p=0.007 and p=0.004, respectively). Disease duration and the number of relapses correlated with delayed P100 latency (r = -0.61, p<0.001 and r = -0.46, p=0.02). GCIPL and RNFL in the SPMS subtype were thinner than in RRMS. Conclusions. The retinal structure and optic nerve function of MS patients are worse than those of normal individuals. GCIPL and RNFL thinning occurs at 6 and 12 months but do not correlate with disease duration, the number of relapses, and degree of disability. © 2021 Riwanti Estiasari et al. |
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Hindawi Limited |
20901852 |
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Article |
Q3 |
365 |
12980 |
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776 |
Liem I.K., Oktavina R., Zakiyah, Anggraini D., Deraya I.E., Kodariah R., Krisnuhoni E., Wuyung P.E. |
55802927800;57224993301;57224999441;57225000673;57216313121;14010667100;35310982200;57192889605; |
Intravenous injection of umbilical cord-derived mesenchymal stem cells improved regeneration of rat liver after 2aaf/ccl4-induced injury |
2021 |
OnLine Journal of Biological Sciences |
21 |
2 |
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317 |
326 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108885347&doi=10.3844%2fojbsci.2021.317.326&partnerID=40&md5=e4defc3d20063b1647d2241805bc3694 |
Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell and Tissue Engineering Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine and Health Science, Universitas Kristen Krida Wacana, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Yarsi, Jakarta, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Animal Research Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Liem, I.K., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell and Tissue Engineering Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oktavina, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine and Health Science, Universitas Kristen Krida Wacana, Jakarta, Indonesia; Zakiyah, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Universitas Yarsi, Jakarta, Indonesia; Anggraini, D., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell and Tissue Engineering Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Deraya, I.E., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kodariah, R., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Krisnuhoni, E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wuyung, P.E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Animal Research Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
The effectivity of Mesenchymal Stem Cell (MSC) therapy for chronic liver injury is still questioned due to its possibility to have a pro-fibrotic effects. Other consideration is the preferably peripheral Intravenous (IV) route of application rather than direct to the target organ, such as portal vein or splenic vein, since the most of MSC will be trapped in the lung and other organs. Therefore, a study has been carried out in an animal model of chronic liver injury, 2AAF/CCl4 rats, to find out whether IV injection of single dose, 1×106 human umbilical cord-derived MSC (hUC-MSC) can regenerate the liver tissue and reduce the fibrosis. Male Wistar rats (n = 18, 8 weeks, 160-200 g) were divided into three groups of six rats, i.e., group I (control/healthy rats), group II (2AAF/CCl4-induced liver injury with hUC-MSC injected rats) and group III (2AAF/CCl4-incuded liver injury without hUC-MSC injected rats). Gross anatomical features of the livers and blood examination were tested. There was no significant different of the Alanine Aminotransferase (ALT) and Albumin serum level between groups; however there was a tendency of ALT decrease and Albumin increase in stem cells treated rats (group II). Histopathological observation using hematoxylin eosin and Masson’s trichrome staining showed an improvement in the liver damage condition (reduction of necrosis and coverage area of fat degeneration) and an improvement in the fibrosis condition in the group II compared to the group III. None of group II rat had fallen into cirrhosis as seen in group III. Immunohistochemistry staining against Caspase 3 (biomarker for apoptosis) also showed significant reduction (p = 0.038; Tukey multiple comparison test) of group II expression index (2.74%) compared to the group III (8.64%). In conclusion, IV injection of single dose, 1×106 hUC-MSC could regenerate the liver tissue and reduce the fibrosis in 2AAF/CCl4 rats model of chronic liver injury. © 2021 Isabella Kurnia Liem, Reni Oktavina, Zakiyah, Dian Anggraini, Irwina Eka Deraya, Ria Kodariah, Ening Krisnuhoni, and Puspita Eka Wuyung. |
2AAF/CCl4; Caspase 3; Liver Fibrosis; Liver Injury; Liver Regeneration; MSC |
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Science Publications |
16084217 |
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Article |
Q4 |
152 |
23000 |
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778 |
Miftahussurur M., Windia A., Syam A.F., Nusi I.A., Alfaray R.I., Fauzia K.A., Kahar H., Purbayu H., Sugihartono T., Setiawan P.B., Maimunah U., Kholili U., Thamrin H., Vidyani A., Doohan D., Waskito L.A., Rezkitha Y.A.A., Siregar G.A., Yamaoka Y. |
56323903000;57224923195;8443384400;56543515200;57215962996;57204649404;57218903823;57194162048;57194156387;6507682592;56543645400;57209663659;57204648560;57211316314;57204644036;57192177367;56543533600;56483277100;55183784100; |
Diagnostic value of 14C urea breath test for Helicobacter pylori detection compared by histopathology in indonesian dyspeptic patients |
2021 |
Clinical and Experimental Gastroenterology |
14 |
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291 |
296 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108652378&doi=10.2147%2fCEG.S306626&partnerID=40&md5=ed8411e8e8e3e089aef5e0d750c1da27 |
Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Faculty of Medicine, University of Muhammadiyah Surabaya, East Java, Surabaya, 60113, Indonesia; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatra Utara, Medan, 20155, Indonesia |
Miftahussurur, M., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia, Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia; Windia, A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Syam, A.F., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Nusi, I.A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Alfaray, R.I., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Fauzia, K.A., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Kahar, H., Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Purbayu, H., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Sugihartono, T., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Setiawan, P.B., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Maimunah, U., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Kholili, U., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Thamrin, H., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Vidyani, A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Doohan, D., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia; Waskito, L.A., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia; Rezkitha, Y.A.A., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia, Faculty of Medicine, University of Muhammadiyah Surabaya, East Java, Surabaya, 60113, Indonesia; Siregar, G.A., Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatra Utara, Medan, 20155, Indonesia; Yamaoka, Y., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan |
Purpose: Histopathology method is often used as a gold standard diagnostic for Helicobacter pylori infection in Indonesia. However, it requires an endoscopic procedure which is limited in Indonesia. A non-invasive method, such as14C Urea Breath Test (UBT), is more favorable; however, this particular method has not been validated yet. Patients and Methods: A total of 55 dyspeptic patients underwent gastroscopy and14C-UBT test. We used Heliprobe® UBT for UBT test. As for the histology, May-Giemsa staining of two gastric biopsies (from the antrum and corpus) were evaluated following the Updated Sydney System. Results: The Receiver Operating Characteristics analysis showed that the optimum cut-off value was 57 with excellence Area under Curve = 0.955 (95% CI = 0.861–1.000). By applying the optimum cut-off value, Heliprobe® UBT showed 92.31% for sensitivity, 97.62% for specificity, 92.31% for positive predictive value, 97.62% for negative predictive value, 38.77 for positive likelihood ratio, 0.0788 for negative likelihood ratio, and 96.36% for the accuracy. Conclusion: The14C-UBT is an accurate test for H. pylori diagnosis with excellent sensitivity, specificity, and accuracy. The different optimum cut-off points suggested that a validation is absolutely necessary for new test prior application to the new population. © 2021 Miftahussurur et al. |
Diagnostic; Helicobacter pylori; Infectious disease; UBT |
urea c 14; adult; Article; bacterium identification; controlled study; cross-sectional study; diagnostic accuracy; diagnostic value; dyspepsia; female; gastroscopy; Helicobacter infection; Helicobacter pylori; histopathology; human; human tissue; Indonesian; intermethod comparison; major clinical study; male; May Giemsa staining; middle aged; negative likelihood ratio; nonhuman; positive likelihood ratio; predictive value; receiver operating characteristic; sensitivity and specificity; statistical analysis; stomach antrum; stomach biopsy; stomach corpus; urea breath test; validation study |
Dove Medical Press Ltd |
11787023 |
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Article |
Q2 |
1113 |
3723 |
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780 |
Giantini A., Timan I.S., Listiyaningsih E., Dharma R., Setiabudy R., Alwi I., Partakusuma L.G., Indrasari N.D., Harahap· A.R., Suparmin· S., Sahar W., Sukmawan R. |
12776781400;6602793366;57224237184;12777817700;6602316235;15055173800;57224924047;6506289872;57224930255;57218100688;57224929934;8651025300; |
Comparison of Light Transmission Aggregometry and VerifyNow in Detecting Clopidogrel Resistance and Factors Affecting Clopidogrel Resistance in AMI-EST Patients Undergoing Percutaneous Coronary Intervention: A Cross-Sectional Study |
2021 |
Indonesian Biomedical Journal |
13 |
2 |
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163 |
169 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108601516&doi=10.18585%2finabj.v13i2.1477&partnerID=40&md5=2ade19315f56303e4e2ab7f2428ec652 |
Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Clinical Pathology, Cipto Mangunkusumo National Central General Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Harapan Kita Heart and Vascular Hospital, Jl. Letjen S. Parman Kav.87, Jakarta, Indonesia; Department of Internal Medicine, Cardiology Division, Metropolitan Medical Centre (MMC) Hospital, Jl. H.R. Rasuna Said Kav. C-21, Jakarta, Indonesia; Eijkman Institute, Jl. Pangeran Diponegoro No. 69, Jakarta, Indonesia |
Giantini, A., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Department of Clinical Pathology, Cipto Mangunkusumo National Central General Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Timan, I.S., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Department of Clinical Pathology, Cipto Mangunkusumo National Central General Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Listiyaningsih, E., Harapan Kita Heart and Vascular Hospital, Jl. Letjen S. Parman Kav.87, Jakarta, Indonesia; Dharma, R., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Department of Clinical Pathology, Cipto Mangunkusumo National Central General Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Setiabudy, R., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Alwi, I., Department of Internal Medicine, Cardiology Division, Metropolitan Medical Centre (MMC) Hospital, Jl. H.R. Rasuna Said Kav. C-21, Jakarta, Indonesia; Partakusuma, L.G., Harapan Kita Heart and Vascular Hospital, Jl. Letjen S. Parman Kav.87, Jakarta, Indonesia; Indrasari, N.D., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Department of Clinical Pathology, Cipto Mangunkusumo National Central General Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Harahap·, A.R., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Eijkman Institute, Jl. Pangeran Diponegoro No. 69, Jakarta, Indonesia; Suparmin·, S., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Sahar, W., Harapan Kita Heart and Vascular Hospital, Jl. Letjen S. Parman Kav.87, Jakarta, Indonesia; Sukmawan, R., Harapan Kita Heart and Vascular Hospital, Jl. Letjen S. Parman Kav.87, Jakarta, Indonesia |
BACKGROUND: Light transmission aggregometry (LTA) and VerifyNow is commonly used to measure platelet responsiveness to clopidogrel. This study aimed to compare the results of LTA and VerifyNow P2Y12 assay for assessing the clopidogrel resistance in patients undergoing percutaneous coronary intervention and determine factors affecting clopidogrel resistance. METHODS: The subjects were 119 patients who underwent percutaneous coronary intervention (PCI) and had given loading dose of 600 mg clopidogrel. Blood samples were taken at 6 hour after clopidogrel loading dose. Platelet aggregation was measured by LTA and Verify Now. RESULTS: LTA and VerifyNow assay showed fair agreement with Kappa=0.270, p=0.001. The proportion of resistance to clopidogrel using VerifyNow was 21.8% and LTA was 47.1%. Patients with diabetes melitus were more likely to develop clopidogrel resistance than patients without diabetes (OR of 7.67; 95% CI: 1.87-31.50; p=0.005). CONCLUSION: The ability of LTA and VerifyNow in detecting clopidogrel resistance were not comparable. Multivariate analysis results for VerifyNow shows diabetes mellitus as the greatest predictors of clopidogrel resistance. © 2021. All Rights Reserved. |
agreement; clopidogrel resistance; LTA; predictor; VerifyNow |
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Prodia Education and Research Institute |
20853297 |
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Article |
Q4 |
160 |
22228 |
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