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388 |
Vityadewi N., Bangun K., Budiman, Winarsih W., Fauzi A.R. |
57218771358;36902624600;57222390006;16053776500;57203133889; |
Auricular cartilage regeneration on donor site defect with one-sided perichondrial cartilage graft in an experimental rabbit model |
2021 |
European Journal of Plastic Surgery |
44 |
3 |
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307 |
314 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099103344&doi=10.1007%2fs00238-020-01765-2&partnerID=40&md5=584c9d67f1904c8e4053cf3ba2855fbe |
Plastic, Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia; Plastic Surgery Reconstruction and Aesthetics Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Division of Plastic Reconstructive Aesthetic Surgery, Department of Surgery, Gatot Subroto Army Hospital, Jakarta, Indonesia; Division of Pathology, Department of Veterinary Clinic Reproduction and Pathology, Bogor Agricultural University, Bogor, 16680, Indonesia |
Vityadewi, N., Plastic, Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia; Bangun, K., Plastic Surgery Reconstruction and Aesthetics Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Budiman, Division of Plastic Reconstructive Aesthetic Surgery, Department of Surgery, Gatot Subroto Army Hospital, Jakarta, Indonesia; Winarsih, W., Division of Pathology, Department of Veterinary Clinic Reproduction and Pathology, Bogor Agricultural University, Bogor, 16680, Indonesia; Fauzi, A.R., Plastic, Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia |
Background: Auricular cartilage is considered the source for cartilage grafts with good esthetic results and is often used in augmentation rhinoplasty. Most revision procedures require grafting, and the auricular cartilage can be the source for secondary rhinoplasty. Due to limited donor locations, donor site optimization of graft material is very important. We aimed to evaluate the healing process from the donor site, including the regeneration of cartilage from the donor site in an experimental animal model. Methods: Six New Zealand white rabbits were used for the investigation of cartilage regeneration from donor defects with one-sided perichondrium. Cartilage defect measuring 0.5 × 3 cm was made in rabbit ears. Two trial groups with 12 ears in each group were formed (one-sided perichondrium vs without perichondrium). Macroscopic and microscopic evaluation examinations were performed at week 4. The gap and thickness of the donor defect were measured with a centimeter grinder for macroscopic evaluation. Results: While macroscopic evaluation of wound thickness and the gap was not significant between groups (p = 1.00, p = 0.053, respectively), microscopic evaluation showed immature cartilage formation at week 4 of the donor defect with one-sided perichondrium (p = 0.004). Conclusions: The donor defect with one-sided perichondrium showed new cartilage formation within the area of the perichondrium. These findings showed the regeneration of cartilage was developed at the donor defects with one-sided perichondrium in the fourth week. Level of evidence: Not ratable. © 2021, Springer-Verlag GmbH Germany, part of Springer Nature. |
Auricular cartilage graft; Cartilage healing; Cartilage regeneration; Donor defect |
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Springer Science and Business Media Deutschland GmbH |
0930343X |
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Article |
Q3 |
219 |
18194 |
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389 |
Bangun K., Sukasah C.L., Dilogo I.H., Indrani D.J., Siregar N.C., Pandelaki J., Iskandriati D., Kekalih A., Halim J. |
36902624600;57218391534;56161962800;6602774472;6508087790;35759266900;6507742011;55633562200;57219398869; |
Bone Growth Capacity of Human Umbilical Cord Mesenchymal Stem Cells and BMP-2 Seeded Into Hydroxyapatite/Chitosan/Gelatin Scaffold in Alveolar Cleft Defects: An Experimental Study in Goat |
2021 |
Cleft Palate-Craniofacial Journal |
58 |
6 |
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707 |
717 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092575595&doi=10.1177%2f1055665620962360&partnerID=40&md5=a3280d360d1de28c8353dffc23d716b3 |
Department of Plastic and Reconstructive Surgery, Cleft and Craniofacial Center, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Unit Pelayanan Terpadu Teknologi Kedokteran Sel Punca (Stem Cell Research Center), Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Dental Material Science and Technology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Anatomical Pathology Department, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Radiology Department of Cipto, Mangunkusumo General Hospital, Jakarta, Indonesia; Primate Research Center of Bogor Agricultural Institute, Bogor, Indonesia; Community Medicine Department, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Bangun, K., Department of Plastic and Reconstructive Surgery, Cleft and Craniofacial Center, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sukasah, C.L., Department of Plastic and Reconstructive Surgery, Cleft and Craniofacial Center, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dilogo, I.H., Unit Pelayanan Terpadu Teknologi Kedokteran Sel Punca (Stem Cell Research Center), Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Indrani, D.J., Department of Dental Material Science and Technology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Siregar, N.C., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Anatomical Pathology Department, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pandelaki, J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Radiology Department of Cipto, Mangunkusumo General Hospital, Jakarta, Indonesia; Iskandriati, D., Primate Research Center of Bogor Agricultural Institute, Bogor, Indonesia; Kekalih, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Community Medicine Department, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Halim, J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Objective: To evaluate bone regeneration in alveolar defects treated with human umbilical cord–derived mesenchymal stem cells (hUCMSCs), hydroxyapatite/chitosan/gelatin (HA/CS/Gel) scaffold, and bone morphogenic protein-2 (BMP-2) in Capra hircus models. Design: Randomized posttest-only control group design. Setting: Animal Hospital at Bogor Agricultural Institute. Participants: Healthy and equally treated 24 female Capra hircus/goats. Intervention: Animals were randomly assigned to 3 experimental group design (iliac crest alveolar bone graft/ICABG [control], HA/Cs/Gel+BMP-2 [Novosys], and HA/Cs/Gel+BMP-2+UCMSCs). Graft materials were implanted in surgically made alveolar defects. Main Outcome Measures: Postoperative functional score and operating time were assessed. New bone growth, bone density, inflammatory cells recruitment, and neoangiogenesis were evaluated based on radiological and histological approach at 2 time points, week 4 and 12. Statistical analysis was done between treatment groups. Results: Operating time was 34% faster and functional score 94.5% more superior in HA/Cs/Gel+BMP-2+hUCMSC group. Bone growth capacity in HA/Cs/Gel+BMP-2+UCMSCs mimicked ICABG, but ICABG showed possibility of bone loss between week 4 and 12. The HA/Cs/Gel+BMP-2+UCMSCs showed early bone repopulation and unseen inflammatory cells and angiogenesis on week 12. Discussion and Conclusion: The HA/Cs/Gel+BMP-2+hUCMSCs were superior in enhancing new bone growth without donor site morbidity compared to ICABG. The presence of hUCMSCs in tissue-engineered alveolar bone graft (ABG), supported with paracrine activity of the resident stem cells, initiated earlier new bone repopulation, and completed faster bone regeneration. The HA/Cs/Gel scaffold seeded with UCMSCs+BMP-2 is a safe substitute of ICABG to close alveolar bone defects suitable for patients with cleft lip, alveolus, and palate. © American Cleft Palate-Craniofacial Association. All rights reserved 2020. |
alveolar bone grafts; bone regeneration; hydroxyapatite/chitosan/gelatin scaffold; iliac crest bone graft; mesenchymal stem cells; tissue engineering |
bone morphogenetic protein 2; chitosan; gelatin; hydroxyapatite; gelatin; hydroxyapatite; adult; alveolar bone; alveolar bone grafting; angiogenesis; animal experiment; animal model; animal tissue; Article; bone density; bone graft; bone growth; bone regeneration; controlled study; domestic goat; donor site; female; histology; human; human cell; iliac crest; inflammatory cell; jaw malformation; morbidity; nonhuman; operation duration; osteolysis; outcome assessment; paracrine signaling; umbilical cord mesenchymal stem cell; animal; bone development; goat; mesenchymal stem cell; tissue scaffold; umbilical cord; Animals; Bone Development; Bone Regeneration; Chitosan; Durapatite; Female; Gelatin; Goats; Humans; Mesenchymal Stem Cells; Tissue Scaffolds; Umbilical Cord |
SAGE Publications Ltd |
10556656 |
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34047209 |
Article |
Q2 |
641 |
7859 |
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390 |
Umbarawan Y., Enoura A., Ogura H., Sato T., Horikawa M., Ishii T., Sunaga H., Matsui H., Yokoyama T., Kawakami R., Maeno T., Setou M., Kurabayashi M., Iso T. |
57196077830;57224226756;57224226814;57202946030;57195494134;57224227073;55061468300;57212330485;7403358134;57210447153;35407637300;14326068500;7103371684;7003498756; |
Fabp5 is a sensitive marker for lipid-rich macrophages in the luminal side of atherosclerotic lesions |
2021 |
International Heart Journal |
62 |
3 |
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666 |
676 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107318921&doi=10.1536%2fihj.20-676&partnerID=40&md5=50711618426db51f56d9cb4d728fc9ca |
Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan; Department of Internal Medicine, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Maebashi, Japan; Department of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan; International Mass Imaging Center, Hamamatsu University School of Medicine, Hamamatsu, Japan; Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Hiroshima, Japan; Center for Liberal Arts and Sciences, Ashikaga University, Ashikaga, Japan; Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan; Department of Systems Molecular Anatomy, Institute for Medical Photonics Research, Preeminent Medical Photonics Education & Research Center, Hamamatsu, Japan |
Umbarawan, Y., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan, Department of Internal Medicine, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Enoura, A., Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Maebashi, Japan; Ogura, H., Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Maebashi, Japan; Sato, T., Department of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan, International Mass Imaging Center, Hamamatsu University School of Medicine, Hamamatsu, Japan; Horikawa, M., Department of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan, International Mass Imaging Center, Hamamatsu University School of Medicine, Hamamatsu, Japan, Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Hiroshima, Japan; Ishii, T., Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Maebashi, Japan; Sunaga, H., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan, Center for Liberal Arts and Sciences, Ashikaga University, Ashikaga, Japan; Matsui, H., Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Maebashi, Japan; Yokoyama, T., Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Maebashi, Japan; Kawakami, R., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan; Maeno, T., Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan; Setou, M., Department of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan, International Mass Imaging Center, Hamamatsu University School of Medicine, Hamamatsu, Japan, Department of Systems Molecular Anatomy, Institute for Medical Photonics Research, Preeminent Medical Photonics Education & Research Center, Hamamatsu, Japan; Kurabayashi, M., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan; Iso, T., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan |
Lipid-rich macrophages in atherosclerotic lesions are thought to be derived from myeloid and vascular smooth muscle cells. A series of studies with genetic and pharmacological inhibition of fatty acid binding protein 4 (FABP4) and FABP5 and bone marrow transplant experiments with FABP4/5 deficient cells in mice have demonstrated that these play an important role in the development of atherosclerosis. However, it is still uncertain about the differential cell-type specificity and distribution between FABP4- and FABP5-expressing cells in early- and late-stage atherosclerotic lesions. In this study, we first explored spatial distribution of FABP4/5 in atherosclerotic lesions in apolipoprotein E deficient (ApoE-/-) mice. FABP4 was only marginally detected in early and advanced lesions, whereas FABP5 was abundantly expressed in these lesions. In advanced lesions, the FABP5-positive area was mostly restricted to the foam cell layer adjacent to the lumen above collagen and elastic fibers with a high signal/noise ratio. Oil red O (ORO) staining revealed that FABP5-positive cells were lipidrich in early and advanced lesions. Together, most of lipid-rich FABP5-positive cells reside adjacent to the lumen above collagen and elastic fibers. We next studied involvement of FABP5 in lesion formation of atherosclerosis using ApoE-/- FABP5-/- mice. However, deletion of FABP5 did not affect the development of atherosclerosis. These findings, along with previous reports, suggest a novel notion that FABP5 is a sensitive marker for bone marrow-derived lipid-rich macrophages in the luminal side of atherosclerotic lesions, although its functional significance remains elusive. © 2021, International Heart Journal Association. All rights reserved. |
Apolipoprotein E knockout mice; Atherosclerosis; Foam cell; Oil red O staining |
apolipoprotein E; CD68 antigen; collagen; fatty acid binding protein 4; fatty acid binding protein 5; Ki 67 antigen; Mac 3; smooth muscle actin; unclassified drug; Fabp4 protein, mouse; Fabp5 protein, mouse; fatty acid binding protein; tumor protein; adipogenesis; animal cell; animal experiment; animal model; animal tissue; apolipoprotein E knockout mouse; Article; atherosclerotic plaque; blood vessel wall; bone marrow transplantation; electrospray mass spectrometry; foam cell; image analysis; immunohistochemistry; lipid rich macrophage; lipid storage; macrophage; mouse; nonhuman; oil red O staining; signal noise ratio; staining; tissue preparation; vascular smooth muscle cell; animal; atherosclerosis; immunology; metabolism; Animals; Atherosclerosis; Fatty Acid-Binding Proteins; Foam Cell |
International Heart Journal Association |
13492365 |
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33994513 |
Article |
Q2 |
555 |
9100 |
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391 |
Wente-Schulz S., Aksenova M., Awan A., Ambarsari C.G., Becherucci F., Emma F., Fila M., Francisco T., Gokce I., Gülhan B., Hansen M., Jahnukainen T., Kallash M., Kamperis K., Mason S., Mastrangelo A., Mencarelli F., Niwinska-Faryna B., Riordan M., Rus R.R., Saygili S., Serdaroglu E., Taner S., Topaloglu R., Vidal E., Woroniecki R., Yel S., Zieg J., Pape L., Boyer O., Buder K., Bulut Ä°.K., Cornelissen E.A.M., del Mar Espino Hernández M., Hooman N., Kemper M., Maquet J., Santos F., Walden U., The international TIN study group |
57219293227;56461027300;7005794049;57211850895;23391748500;6701866332;47760976500;55642167100;16238883200;16244621000;57026872000;6602193869;55189985500;6507713677;56025783100;16245571200;23989069700;24402868000;36828392800;56126830800;36926397400;55910586900;57204046122;7005610220;57200885825;8351699100;43861951500;37762449000;7007073757;8509255100;57423156500;42360924700;7003896668;56868570600;22634317400;55946766900;57199406014;7202141204;57189522337; |
Aetiology, course and treatment of acute tubulointerstitial nephritis in paediatric patients: A cross-sectional web-based survey |
2021 |
BMJ Open |
11 |
5 |
e047059 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107244372&doi=10.1136%2fbmjopen-2020-047059&partnerID=40&md5=8b9d8549b7d6c5d3a71a823dffc235d5 |
Department of Pediatric Nephrology, MHH, Hannover, Germany; Department of Pediatric Nephrology, Veltischev Research and Clinical Institute for Pediatrics, The Pirogov Russian National Research Medical University, Moskva, Russian Federation; Department of Pediatric Nephrology, Temple Street Children's University Hospital, Dublin, Ireland; Department of Pediatric Nephrology, Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Central Jakarta, Indonesia; Department of Pediatric Nephrology, Meyer Children's Hospital, Florence, Italy; Department of Pediatric Nephrology, Bambino Gesù Children's Hospital, Roma, Italy; Department of Pediatric Nephrology, Montpellier University, Arnaud de Villeneuve Hospital, Montpellier, France; Department of Pediatric Nephrology, Dona Estefânia Hospital, Lisboa, Portugal; Department of Pediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Turkey; Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey; KfH Centre of Pediatric Nephrology, Clementine Kinderhospital, Frankfurt am Main, Germany; Department of Pediatric Nephrology and Transplantation, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland; Department of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, OH, United States; Department of Pediatric Nephrology, Aarhus University Hospital, Aarhus, Denmark; Department of Pediatric Nephrology, Connecticut Children's Medical Center, Hartford, CT, United States; Department of Pediatric Nephrology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pediatric Nephrology, Azienda Ospedaliero-Universitaria di Bologna, Ospedale S. Orsola-Malpighi, Bologna, Italy; Department of Pediatric Nephrology, Karolinska University Hospital, Stockholm, Sweden; Department of Pediatric Nephrology, University Children's Hospital, Ljubljana, Slovenia; Department of Pediatric Nephrology, Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey; Department of Pediatric Nephrology, Dr Behcet Uz Children Hospital, Izmir, Turkey; Department of Pediatric Nephrology, Faculty of Medicine, Ege University, Izmir, Turkey; Department of Pediatric Nephrology, University Hospital of Padova, Padova, Italy; Department of Pediatric Nephrology, Stony Brook Children's Hospital, Stony Brook, NY, United States; Department of Pediatric Nephrology, Faculty of Medicine, Erciyes University, Kayseri, Turkey; Department of Pediatric Nephrology, 2nf Faculty of Medicine, University Hospital Motol, Charles University, Praha, Czech Republic; Department of Pediatrics II, University Hospital Essen, Essen, Germany; Hôpital Necker-Enfants malades, MARHEA, Institut Imagine, Université de Paris, Paris, France; Pediatric Department, University Hospital Carl Gustav Carus, Technical University, Dresden, Germany; Ege University Faculty of Medicine, Izmir, Turkey; Radboud University Medical Center, Nijmegen, Netherlands; Hospital Universitario 12 de Octubre, Madrid, Spain; Ali-Asghar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran; Asklepios Medical School, Hamburg, Germany; CHC Liège, Belgium; Pediatric Nephrology, Hospital Universitario Central de Asturias, University of Oviedo, Spain; Universitätsklinikum Kinderklinik Augsburg, Germany |
Wente-Schulz, S., Department of Pediatric Nephrology, MHH, Hannover, Germany; Aksenova, M., Department of Pediatric Nephrology, Veltischev Research and Clinical Institute for Pediatrics, The Pirogov Russian National Research Medical University, Moskva, Russian Federation; Awan, A., Department of Pediatric Nephrology, Temple Street Children's University Hospital, Dublin, Ireland; Ambarsari, C.G., Department of Pediatric Nephrology, Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Central Jakarta, Indonesia; Becherucci, F., Department of Pediatric Nephrology, Meyer Children's Hospital, Florence, Italy; Emma, F., Department of Pediatric Nephrology, Bambino Gesù Children's Hospital, Roma, Italy; Fila, M., Department of Pediatric Nephrology, Montpellier University, Arnaud de Villeneuve Hospital, Montpellier, France; Francisco, T., Department of Pediatric Nephrology, Dona Estefânia Hospital, Lisboa, Portugal; Gokce, I., Department of Pediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Turkey; Gülhan, B., Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey; Hansen, M., KfH Centre of Pediatric Nephrology, Clementine Kinderhospital, Frankfurt am Main, Germany; Jahnukainen, T., Department of Pediatric Nephrology and Transplantation, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland; Kallash, M., Department of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, OH, United States; Kamperis, K., Department of Pediatric Nephrology, Aarhus University Hospital, Aarhus, Denmark; Mason, S., Department of Pediatric Nephrology, Connecticut Children's Medical Center, Hartford, CT, United States; Mastrangelo, A., Department of Pediatric Nephrology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Mencarelli, F., Department of Pediatric Nephrology, Azienda Ospedaliero-Universitaria di Bologna, Ospedale S. Orsola-Malpighi, Bologna, Italy; Niwinska-Faryna, B., Department of Pediatric Nephrology, Karolinska University Hospital, Stockholm, Sweden; Riordan, M., Department of Pediatric Nephrology, Temple Street Children's University Hospital, Dublin, Ireland; Rus, R.R., Department of Pediatric Nephrology, University Children's Hospital, Ljubljana, Slovenia; Saygili, S., Department of Pediatric Nephrology, Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey; Serdaroglu, E., Department of Pediatric Nephrology, Dr Behcet Uz Children Hospital, Izmir, Turkey; Taner, S., Department of Pediatric Nephrology, Faculty of Medicine, Ege University, Izmir, Turkey; Topaloglu, R., Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey; Vidal, E., Department of Pediatric Nephrology, University Hospital of Padova, Padova, Italy; Woroniecki, R., Department of Pediatric Nephrology, Stony Brook Children's Hospital, Stony Brook, NY, United States; Yel, S., Department of Pediatric Nephrology, Faculty of Medicine, Erciyes University, Kayseri, Turkey; Zieg, J., Department of Pediatric Nephrology, 2nf Faculty of Medicine, University Hospital Motol, Charles University, Praha, Czech Republic; Pape, L., Department of Pediatrics II, University Hospital Essen, Essen, Germany; Boyer, O., Hôpital Necker-Enfants malades, MARHEA, Institut Imagine, Université de Paris, Paris, France; Buder, K., Pediatric Department, University Hospital Carl Gustav Carus, Technical University, Dresden, Germany; Bulut, Ä°.K., Ege University Faculty of Medicine, Izmir, Turkey; Cornelissen, E.A.M., Radboud University Medical Center, Nijmegen, Netherlands; del Mar Espino Hernández, M., Hospital Universitario 12 de Octubre, Madrid, Spain; Hooman, N., Ali-Asghar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran; Kemper, M., Asklepios Medical School, Hamburg, Germany; Maquet, J., CHC Liège, Belgium; Santos, F., Pediatric Nephrology, Hospital Universitario Central de Asturias, University of Oviedo, Spain; Walden, U., Universitätsklinikum Kinderklinik Augsburg, Germany; The international TIN study group |
Background Acute tubulointerstitial nephritis (TIN) is a significant cause of acute renal failure in paediatric and adult patients. There are no large paediatric series focusing on the aetiology, treatment and courses of acute TIN. Patients, design and setting We collected retrospective clinical data from paediatric patients with acute biopsy-proven TIN by means of an online survey. Members of four professional societies were invited to participate. Results Thirty-nine physicians from 18 countries responded. 171 patients with acute TIN were included (54% female, median age 12 years). The most frequent causes were tubulointerstitial nephritis and uveitis syndrome in 31% and drug-induced TIN in 30% (the majority of these caused by non-steroidal anti-inflammatory drugs). In 28% of patients, no initiating noxae were identified (idiopathic TIN). Median estimated glomerular filtration rate (eGFR) rose significantly from 31 at time of renal biopsy to 86 mL/ min/1.73 m2 3-6 months later (p<0.001). After 3-6 months, eGFR normalised in 41% of patients (eGFR ≥90 mL/ min/1.73 m2), with only 3% having severe or end-stage impairment of renal function (<30 mL/min/1.73 m2). 80% of patients received corticosteroid therapy. Median eGFR after 3-6 months did not differ between steroid-treated and steroid-untreated patients. Other immunosuppressants were used in 18% (n=31) of patients, 21 of whom received mycophenolate mofetil. Conclusions Despite different aetiologies, acute paediatric TIN had a favourable outcome overall with 88% of patients showing no or mild impairment of eGFR after 3-6 months. Prospective randomised controlled trials are needed to evaluate the efficacy of glucocorticoid treatment in paediatric patients with acute TIN. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
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aciclovir; amoxicillin plus clavulanic acid; antiinfective agent; bee venom; chlorpheniramine maleate; corticosteroid; cotrimoxazole; flurbiprofen; herbaceous agent; hydrochlorothiazide; ibuprofen; immunosuppressive agent; ketoprofen; levetiracetam; mesalazine; methylprednisolone; midecamycin; morniflumate; mycophenolate mofetil; nonsteroid antiinflammatory agent; oxcarbazepine; paracetamol; penicillin G potassium; prednisolone; prednisone; toxic substance; anuria; arthralgia; Article; child; clinical feature; cohort analysis; controlled study; corticosteroid therapy; cross-sectional study; disease course; end stage renal disease; enuresis; estimated glomerular filtration rate; eye disease; fatigue; female; fever; flank pain; glucosuria; headache; health care survey; hematuria; human; huma |
BMJ Publishing Group |
20446055 |
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34049919 |
Article |
Q1 |
1132 |
3624 |
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394 |
Abdullah M., Sudrajat D.G., Muzellina V.N., Kurniawan J., Rizka A., Utari A.P., Pribadi R.R., Idrus M.F., Yusra Y., Meilany S., Surandy A., Shatri H., Rinaldi I., Pitoyo C.W., Renaldi K. |
7103393434;54893136100;57223968527;57193251655;57203243658;57113585900;57194732282;57223976376;57220998367;57193709281;57223964417;28767986500;23475122400;26022606900;57190963547; |
The value of anal swab RT-PCR for COVID-19 diagnosis in adult Indonesian patients |
2021 |
BMJ Open Gastroenterology |
8 |
1 |
e000590 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106611204&doi=10.1136%2fbmjgast-2020-000590&partnerID=40&md5=cc17ce689ac73f1e46021151c9319871 |
Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Indonesia Medical Education and Research Institute - Human Cancer Research Center, University of Indonesia Faculty of Medicine, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Hepatobilliary Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Geriatric Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Department of Clinical Pathology, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region Jakarta, Indonesia; Research Center for Virology and Cancer Pathobiology, University of Indonesia Faculty of Medicine, Jakarta, Special Capital Region of Jakarta, Indonesia; Psychosomatic and Palliative Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Special Capital Region of Jakarta, Central Jakarta, Indonesia; Hematology and Medical Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Respirology and Critical Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia |
Abdullah, M., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia, Indonesia Medical Education and Research Institute - Human Cancer Research Center, University of Indonesia Faculty of Medicine, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Sudrajat, D.G., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Muzellina, V.N., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Kurniawan, J., Hepatobilliary Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Rizka, A., Geriatric Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Utari, A.P., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Pribadi, R.R., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Idrus, M.F., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Yusra, Y., Department of Clinical Pathology, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region Jakarta, Indonesia; Meilany, S., Research Center for Virology and Cancer Pathobiology, University of Indonesia Faculty of Medicine, Jakarta, Special Capital Region of Jakarta, Indonesia; Surandy, A., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Shatri, H., Psychosomatic and Palliative Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Special Capital Region of Jakarta, Central Jakarta, Indonesia; Rinaldi, I., Hematology and Medical Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Pitoyo, C.W., Respirology and Critical Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Renaldi, K., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia |
Objective This study will test the performance of the anal swab PCR test when compared with the nasopharyngeal swab PCR test as a diagnostic tool for COVID-19. Design An observational descriptive study which included hospitalised suspected, or probable cases of hopitalised COVID-19 patients, conducted in Dr. Cipto Mangunkusumo National Hospital, Ciputra Hospital, Mitra Keluarga Depok Hospital and Mitra Keluarga Kelapa Gading Hospital, Indonesia. Epidemiological, clinical, laboratory and radiology data were obtained. Nasopharyngeal and anal swabs specimens were collected for SARS-CoV-2 RNA detection. Results We analysed 136 subjects as part of this study. The clinical spectrum of COVID-19 manifesation in this study was typical of hospitalised patients, with 25% classified as mild cases, 14.7% in severe condition and 12.5% of subjects classified as having acute respiratory distress syndrome. When compared with nasopharyngeal swab as the standard specimen for reverse transcription polymerase chain reaction (RT-PCR) detection of SARS-CoV-2 antigen, the sensitivity and specificity of the anal swab was 36.7% and 93.8%, respectively. The positive and negative predictive value were 97.8% and 16.5 %, respectively. The performance of the anal swab remained similar when only the subgroup of patients with gastrointestinal symptoms (n=92, 67.6%) was analysed (sensitivity 40% and specificity 91.7%). Out of all the subjects included in analysis, 67.6% had gastrointestinal symptoms. Similarly, 73.3% of patients in the anal swab-positive group had gastrointestinal symptoms. The two most common gastrointestinal symptoms in the subjects' population were nausea and anorexia. Conclusion Anal swab specimen has low sensitivity (36.7%) but high specificity (93.8%) for detecting SARS-CoV-2 antigen by RT-PCR. Only one additional positive result was found by anal swab among the nasopharyngeal swab-negative group. Anal swab may not be needed as an additional test at the beginning of a patient's diagnostic investigation and nasopharyngeal swab RT-PCR remains as the standard diagnostic test for COVID-19. © 2020 American Society of Mechanical Engineers (ASME). All rights reserved. |
anal; COVID-19; diagnostic virology |
abdominal pain; adult; adult respiratory distress syndrome; anal swab; anorexia; Article; body mass; clinical laboratory; controlled study; coronavirus disease 2019; coughing; COVID-19 testing; current smoker; diagnostic test accuracy study; diarrhea; ex-smoker; female; fever; gastrointestinal symptom; headache; heart disease; hospital patient; human; hypertension; Indonesian; lung disease; major clinical study; malaise; male; mortality rate; nasopharyngeal swab; nausea; non insulin dependent diabetes mellitus; practice guideline; predictive value; priority journal; respiratory tract infection; reverse transcription polymerase chain reaction; sensitivity and specificity; sore throat |
BMJ Publishing Group |
20544774 |
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Article |
Q1 |
1240 |
3126 |
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396 |
Raharjo S.B., Chandranegara A.F., Hanafy D.A., Yamin M., Rasyid H.E., Haryadi, Rizal A., Ardhianto P., Hermanto D.Y., Yuniadi Y., OneAF Investigators |
57017880700;57224571328;55431326800;23475706300;57224560676;57224559936;57218771291;57208782791;57223816091;57155066100; |
Indonesian registry on atrial fibrillation (OneAF) |
2021 |
Medicine |
100 |
19 |
|
e25725 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107981983&doi=10.1097%2fMD.0000000000025725&partnerID=40&md5=c16e93c69fd23a59227c9462d518a9c8 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita; Pasar Rebo General Hospital; Department of Internal Medicine Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Department of Cardiology, Faculty of Medicine, alas University, Djamil General Hospital, Padang, West Sumatra, Indonesia; Eka Hospital, Pekanbaru, Riau, Indonesia; Department of Cardiology, Faculty of Medicine, Brawijaya University, Syaiful Anwar General Hospital, Malang, Indonesia; Department of Cardiology, Faculty of Medicine, Diponegoro University, Kariadi General Hospital, Semarang, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan KitaJakarta, Indonesia |
Raharjo, S.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita; Chandranegara, A.F., Pasar Rebo General Hospital; Hanafy, D.A., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita; Yamin, M., Department of Internal Medicine Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Rasyid, H.E., Department of Cardiology, Faculty of Medicine, alas University, Djamil General Hospital, Padang, West Sumatra, Indonesia; Haryadi, Eka Hospital, Pekanbaru, Riau, Indonesia; Rizal, A., Department of Cardiology, Faculty of Medicine, Brawijaya University, Syaiful Anwar General Hospital, Malang, Indonesia; Ardhianto, P., Department of Cardiology, Faculty of Medicine, Diponegoro University, Kariadi General Hospital, Semarang, Indonesia; Hermanto, D.Y., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan KitaJakarta, Indonesia; Yuniadi, Y., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan KitaJakarta, Indonesia; OneAF Investigators |
BACKGROUND: Data on the optimal therapeutic international normalized ratio (INR) for non-valvular and valvular atrial fibrillation (AF) in Indonesia is currently unavailable. Therefore, we designed the Indonesian Registry on Atrial Fibrillation (OneAF) registry in order to seek a safe and beneficial range of INR in Indonesian patients with non-valvular and valvular AF. METHODS/DESIGN: The OneAF registry is a nationwide collaboration of the Indonesian Heart Rhythm Society (InaHRS) enrolling all hospitals with cardiac electrophysiologists in Indonesia. It is a prospective, multicentre, nationwide, observational study aiming to recruit non-valvular and valvular AF patients in Indonesia. The registry was started in January 2020 with a planned 2 years of recruitment. There are 2 respondents for this registry: non-cohort and cohort respondents. Non-cohort registry respondents are AF patients at hospitals who fulfill inclusion and exclusion criteria but did not consent for a 24 month follow up. Whereas patients who consented for a 24 month follow up were included as cohort registry respondents. Key data collected includes basic sociodemographic information, symptoms and signs, medical history, results of physical examination and laboratory test, details of diagnostics and treatment measures and events. RESULTS: Currently, a total of 1568 respondents have been enrolled in the non-cohort registry, including 1065 respondents with non-valvular AF (67.8%) and 503 respondents with valvular AF (32.2%). We believe that the OneAF registry will provide insight into the regional variability of anticoagulant treatment for AF, the implementation of rhythm/rate control approaches, and the clinical outcomes concerning cardiocerebrovascular events. TRIAL REGISTRATION: Registered at clinicaltrials.gov (NCT04222868). Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. |
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adolescent; adult; aged; atrial fibrillation; clinical trial; female; human; Indonesia; male; middle aged; multicenter study; prospective study; register; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Atrial Fibrillation; Female; Humans; Indonesia; Male; Middle Aged; Prospective Studies; Registries; Young Adult |
NLM (Medline) |
15365964 |
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34106597 |
Article |
Q4 |
204 |
19087 |
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397 |
Siste K., Hanafi E., Sen L.T., Murtani B.J., Christian H., Limawan A.P., Siswidiani L.P., Adrian |
55644113100;56737010600;57219034101;57216652176;57209266195;57202712511;57219029296;57216932703; |
Implications of COVID-19 and Lockdown on Internet Addiction Among Adolescents: Data From a Developing Country |
2021 |
Frontiers in Psychiatry |
12 |
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665675 |
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6 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107077623&doi=10.3389%2ffpsyt.2021.665675&partnerID=40&md5=19567c64b9f1c1b25ae702d165f6737d |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Siste, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hanafi, E., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sen, L.T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Murtani, B.J., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Christian, H., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Limawan, A.P., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Siswidiani, L.P., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Adrian, Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Introduction: Physical distancing policy during coronavirus disease 2019 (COVID-19) pandemic requires adolescents to spend most of their time at home, thus increasing Internet use duration. Limited social interaction with their peers may lead to loneliness and an increased risk of mental health among adolescents. This study aimed to assess the prevalence of Internet addiction (IA) among adolescents and analyze the influence of psychosocial factors toward the heightened risk of IA during the COVID-19 pandemic. Methods: An online survey comprising sociodemographic questionnaire, Internet Addiction Diagnostic Questionnaire (KDAI), Strengths and Difficulties Questionnaire (SDQ), and Pittsburgh Sleep Quality Index (PSQI) was distributed. Overall, a total of 2,932 adolescents (mean age, 17.38 ± 2.24 years old; female, 78.7%), originating from 33 of 34 provinces in Indonesia, completed the survey. Results: The point prevalence of IA among Indonesian adolescents during the COVID-19 outbreak was 19.3%. Increased Internet use duration, internalization, externalization, low prosocial behavior, and sleep disturbances were found as risk factors of IA, either directly or as mediating variables. Physical distancing, large-scale social restriction (PSBB), and health status were not correlated to IA. Discussion: Physical distancing was not established as a risk of IA. This could be due to other psychological factors such as internalization, externalization, prosocial, and sleep problems that had correlations to IA occurrence among adolescents in the COVID-19 pandemic. Sleep impairment might have resulted from the emotional and behavioral issues and directly contributed to IA development. Conclusion: The present study found the prevalence of IA among Indonesian adolescents to be higher than the adult during the COVID-19 pandemic. Several psychological measures were indicated to increase the risk of IA, while physical distancing did not elevate the risk. Thus, remote schooling is preferable in Indonesia along with proper parental supervision to minimize Internet use for entertainment purposes. © Copyright © 2021 Siste, Hanafi, Sen, Murtani, Christian, Limawan, Siswidiani and Adrian. |
adolescents; coronavirus disease 2019; Indonesia; internet addiction; lockdown; physical distancing; psychopathology; sleep quality |
adolescent; adolescent disease; age distribution; Article; behavior disorder; controlled study; coronavirus disease 2019; demography; developing country; emotional disorder; externalization (behavior); female; health status; health survey; human; Indonesia; Indonesian; internalization (behavior); internet addiction; Internet Addiction Diagnostic Questionnaire; major clinical study; male; national lockdown; pandemic; Pittsburgh Sleep Quality Index; prevalence; prosocial behavior; psychological aspect; questionnaire; risk assessment; sex ratio; sleep disorder; social aspect; social distancing; social psychology; strengths and difficulties questionnaire |
Frontiers Media S.A. |
16640640 |
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Article |
Q1 |
1363 |
2668 |
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398 |
Setiabudiawan B., Sitaresmi M.N., Sapartini G., Sumadiono S., Citraresmi E., Sekartini R., Putra A.M., Jo J. |
57189310070;16040647800;57203168733;55581650500;57224512641;50162572300;57224522586;55345586200; |
Growth Patterns of Indonesian Infants with Cow's Milk Allergy and Fed with Soy-Based Infant Formula |
2021 |
Pediatric Gastroenterology, Hepatology and Nutrition |
24 |
3 |
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316 |
324 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107767665&doi=10.5223%2fPGHN.2021.24.3.316&partnerID=40&md5=426ce2a647c7efc4e412e462e9a020a5 |
Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Child Health, Harapan Kita Child and Mother Hospital, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Danone Nutricia Research, Singapore |
Setiabudiawan, B., Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Sitaresmi, M.N., Department of Child Health, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Sapartini, G., Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Sumadiono, S., Department of Child Health, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Citraresmi, E., Department of Child Health, Harapan Kita Child and Mother Hospital, Jakarta, Indonesia; Sekartini, R., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Putra, A.M., Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Jo, J., Danone Nutricia Research, Singapore |
Purpose: The use of soy-based infant formula has increased widely in infants with cow's milk allergy (CMA). This study aimed to provide evidence on the growth pattern of CMA infants fed with soy-based infant formula in an Indonesian setting. Methods: A multi-site, intervention study was conducted among full-term and normal birth weight CMA infants. Within six months, the subjects were provided with a soy-based infant formula. Weight, height, and head circumference were measured at baseline, weeks 4, 8, 12, 16, 20, and 24. Adverse events were recorded by scoring atopic dermatitis and symptom-based clinical scores. Results: Based on the World Health Organization growth chart, we found that most of subjects had normal nutritional status for weight-for-age, length-for-age, weight-for-length, and head-circumference-for-age. There were statistically significant differences between baseline and end-line for weight-for-age, length-for-age, weight-for-length, and head circumference-for-age nutritional status. No allergic symptoms or intolerance toward soy formula were observed at the end of the intervention period. Conclusion: These results show that infants fed with soy-based infant formula have a normal pattern of growth. Copyright © 2021 by The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Body height; Body weight; Milk hypersensitivity; Soy milk |
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Korean Society of Pediartic Gastroenterology, Hepatology and Nutrition |
22348646 |
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Article |
Q3 |
440 |
11229 |
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400 |
Han W.M., Jiamsakul A., Salleh N.A.M., Choi J.Y., Huy B.V., Yunihastuti E., Do C.D., Merati T.P., Gani Y.M., Kiertiburanakul S., Zhang F., Chan Y.-J., Lee M.-P., Chaiwarith R., Ng O.T., Khusuwan S., Ditangco R., Kumarasamy N., Sangle S., Ross J., Avihingsanon A., Ly P.S., Khol V., Zhang F.J., Zhao H.X., Han N., Lee M.P., Li P.C.K., Lam W., Chan Y.T., Kumarasamy N., Ezhilarasi C., Pujari S., Joshi K., Gaikwad S., Chitalikar A., Sangle S., Mave V., Marbaniang I., Nimkar S., Merati T.P., Wirawan D.N., Yuliana F., Yunihastuti E., Widhani A., Maria S., Karjadi T.H., Tanuma J., Oka S., Nishijima T., Choi J.Y., Na S., Kim J.M., Gani Y.M., Rudi N.B., Azwa I., Kamarulzaman A., Syed Omar S.F., Ponnampalavanar S., Ditangco R., Pasayan M.K., Mationg M.L., Chan Y.J., Ku W.W., Wu P.C., Ke E., Ng O.T., Lim P.L., Lee L.S., Liang D., Avihingsanon A., Gatechompol S., Phanuphak P., Phadungphon C., Phuphuakrat A., Chumla L., Sanmeema N., Chaiwarith R., Sirisanthana T., Praparattanapan J., Nuket K., Khusuwan S., Kantipong P., Kambua P., Nguyen K.V., Bui H.V., Nguyen D.T.H., Nguyen D.T., Do C.D., Ngo A.V., Nguyen L.T., Sohn A.H., Ross J.L., Petersen B., Law M.G., Jiamsakul A., Bijker R., Rupasinghe D., TREAT Asia HIV Observational Database (TAHOD) of the International Epidemiology Databases to Evaluate AIDS (IeDEA) Asia-Pacific Group |
57201984684;55285745500;57209499322;48761023600;55757403300;57221273925;55035577700;8935806500;57188842533;6506539792;23007277900;57258255400;57309539000;13806165200;57215769524;56166613100;55406840800;7003549856;6602877716;57193109926;57196347321;57204852770;57188842644;55503803800;35796801900;57206253688;56143671100;57203375227;57188836039;57188839065;55412491000;55413091200;57205894660;35227451500;55273903300;57188839029;57257928100;24778446900;57189801547;56820043000;57203678680;6601921496;57202976978;8850357600;57202561455;57213345044;57219422563;57208428839;57202558648;57226409961;57294788000;14037572300;7601387767;57188842533;57257789600;55553159100;6603019663;55295731300;36768852500;57258598000;57207954173;36936083900;33667461800;55856943500;56514424400;57257813200;57203665233;10041498300;55992506400;57258040600;57200282477;57193906863;7004982661;56015716600;8277552900;56515326900;55992497800;57203665049;7004277229;35185428900;57192871045;56166613100;6603580797;55285745100;56370854300;56498653200;56970337500;57190300831;56658396600;57208054163;41961438300;7006405275;57217343074;56406054800;55556254800;55285745500;57188697907;57205313395; |
HIV treatment outcomes among people who acquired HIV via injecting drug use in the Asia-Pacific region: a longitudinal cohort study |
2021 |
Journal of the International AIDS Society |
24 |
5 |
e25736 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106697623&doi=10.1002%2fjia2.25736&partnerID=40&md5=5b62ec1b7839280e4b8e69702122c64a |
Kirby Institute, UNSW, Sydney, Australia; HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Centre of Excellence for Research in AIDS (CERiA), University of Malaya, Kuala Lumpur, Malaysia; Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; National Hospital for Tropical Diseases, Hanoi, Viet Nam; Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Bach Mai Hospital, Hanoi, Viet Nam; Faculty of Medicine, Udayana University & Sanglah Hospital, Bali, Indonesia; Hospital Sungai Buloh, Sungai Buloh, Malaysia; Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Beijing Ditan Hospital, Capital Medical University, Beijing, China; Taipei Veterans General Hospital, Taipei, Taiwan; Queen Elizabeth Hospital, Hong Kong; Research Institute for Health Sciences, Chiang Mai, Thailand; Tan Tock Seng Hospital, Tan Tock Seng, Singapore; Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHSChennai, India; BJ Government Medical College and Sassoon General Hospital, Pune, India; TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; Tuberculosis Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; National Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia; Beijing Ditan Hospital, Capital Medical University, Beijing, China; Queen Elizabeth Hospital, Hong Kong; Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHS, Chennai, India; Institute of Infectious Diseases, Pune, India; BJ Government Medical College and Sassoon General Hospital, Pune, India; Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; National Center for Global Health and Medicine, Tokyo, Japan; Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Hospital Sungai Buloh, Sungai Buloh, Malaysia; University Malaya Medical Centre, Kuala Lumpur, Malaysia; Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Taipei Veterans General Hospital, Taipei, Taiwan; Tan Tock Seng Hospital, Singapore; HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Research Institute for Health Sciences, Chiang Mai, Thailand; Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; National Hospital for Tropical Diseases, Hanoi, Viet Nam; Bach Mai Hospital, Hanoi, Viet Nam; TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; The Kirby Institute, UNSW SydneyNSW, Australia |
Han, W.M., Kirby Institute, UNSW, Sydney, Australia, HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Jiamsakul, A., Kirby Institute, UNSW, Sydney, Australia, The Kirby Institute, UNSW SydneyNSW, Australia; Salleh, N.A.M., Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia, Centre of Excellence for Research in AIDS (CERiA), University of Malaya, Kuala Lumpur, Malaysia; Choi, J.Y., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Huy, B.V., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Yunihastuti, E., Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Do, C.D., Bach Mai Hospital, Hanoi, Viet Nam; Merati, T.P., Faculty of Medicine, Udayana University & Sanglah Hospital, Bali, Indonesia; Gani, Y.M., Hospital Sungai Buloh, Sungai Buloh, Malaysia, Hospital Sungai Buloh, Sungai Buloh, Malaysia; Kiertiburanakul, S., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Zhang, F., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Chan, Y.-J., Taipei Veterans General Hospital, Taipei, Taiwan; Lee, M.-P., Queen Elizabeth Hospital, Hong Kong; Chaiwarith, R., Research Institute for Health Sciences, Chiang Mai, Thailand; Ng, O.T., Tan Tock Seng Hospital, Tan Tock Seng, Singapore; Khusuwan, S., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Ditangco, R., Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Kumarasamy, N., Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHSChennai, India; Sangle, S., BJ Government Medical College and Sassoon General Hospital, Pune, India; Ross, J., TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; Avihingsanon, A., HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand, Tuberculosis Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Ly, P.S., National Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia; Khol, V., National Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia; Zhang, F.J., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Zhao, H.X., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Han, N., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Lee, M.P., Queen Elizabeth Hospital, Hong Kong; Li, P.C.K., Queen Elizabeth Hospital, Hong Kong; Lam, W., Queen Elizabeth Hospital, Hong Kong; Chan, Y.T., Queen Elizabeth Hospital, Hong Kong; Kumarasamy, N., Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHS, Chennai, India; Ezhilarasi, C., Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHS, Chennai, India; Pujari, S., Institute of Infectious Diseases, Pune, India; Joshi, K., Institute of Infectious Diseases, Pune, India; Gaikwad, S., Institute of Infectious Diseases, Pune, India; Chitalikar, A., Institute of Infectious Diseases, Pune, India; Sangle, S., BJ Government Medical College and Sassoon General Hospital, Pune, India; Mave, V., BJ Government Medical College and Sassoon General Hospital, Pune, India; Marbaniang, I., BJ Government Medical College and Sassoon General Hospital, Pune, India; Nimkar, S., BJ Government Medical College and Sassoon General Hospital, Pune, India; Merati, T.P., Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; Wirawan, D.N., Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; Yuliana, F., Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; Yunihastuti, E., Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Widhani, A., Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Maria, S., Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Karjadi, T.H., Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Tanuma, J., National Center for Global Health and Medicine, Tokyo, Japan; Oka, S., National Center for Global Health and Medicine, Tokyo, Japan; Nishijima, T., National Center for Global Health and Medicine, Tokyo, Japan; Choi, J.Y., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Na, S., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Kim, J.M., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Gani, Y.M., Hospital Sungai Buloh, Sungai Buloh, Malaysia, Hospital Sungai Buloh, Sungai Buloh, Malaysia; Rudi, N.B., Hospital Sungai Buloh, Sungai Buloh, Malaysia; Azwa, I., University Malaya Medical Centre, Kuala Lumpur, Malaysia; Kamarulzaman, A., University Malaya Medical Centre, Kuala Lumpur, Malaysia; Syed Omar, S.F., University Malaya Medical Centre, Kuala Lumpur, Malaysia; Ponnampalavanar, S., University Malaya Medical Centre, Kuala Lumpur, Malaysia; Ditangco, R., Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Pasayan, M.K., Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Mationg, M.L., Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Chan, Y.J., Taipei Veterans General Hospital, Taipei, Taiwan; Ku, W.W., Taipei Veterans General Hospital, Taipei, Taiwan; Wu, P.C., Taipei Veterans General Hospital, Taipei, Taiwan; Ke, E., Taipei Veterans General Hospital, Taipei, Taiwan; Ng, O.T., Tan Tock Seng Hospital, Singapore; Lim, P.L., Tan Tock Seng Hospital, Singapore; Lee, L.S., Tan Tock Seng Hospital, Singapore; Liang, D., Tan Tock Seng Hospital, Singapore; Avihingsanon, A., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Gatechompol, S., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Phanuphak, P., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Phadungphon, C., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Phuphuakrat, A., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Chumla, L., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Sanmeema, N., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Chaiwarith, R., Research Institute for Health Sciences, Chiang Mai, Thailand; Sirisanthana, T., Research Institute for Health Sciences, Chiang Mai, Thailand; Praparattanapan, J., Research Institute for Health Sciences, Chiang Mai, Thailand; Nuket, K., Research Institute for Health Sciences, Chiang Mai, Thailand; Khusuwan, S., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Kantipong, P., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Kambua, P., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Nguyen, K.V., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Bui, H.V., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Nguyen, D.T.H., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Nguyen, D.T., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Do, C.D., Bach Mai Hospital, Hanoi, Viet Nam; Ngo, A.V., Bach Mai Hospital, Hanoi, Viet Nam; Nguyen, L.T., Bach Mai Hospital, Hanoi, Viet Nam; Sohn, A.H., TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; Ross, J.L., TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; Petersen, B., TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; Law, M.G., The Kirby Institute, UNSW SydneyNSW, Australia; Jiamsakul, A., Kirby Institute, UNSW, Sydney, Australia, The Kirby Institute, UNSW SydneyNSW, Australia; Bijker, R., The Kirby Institute, UNSW SydneyNSW, Australia; Rupasinghe, D., The Kirby Institute, UNSW SydneyNSW, Australia; TREAT Asia HIV Observational Database (TAHOD) of the International Epidemiology Databases to Evaluate AIDS (IeDEA) Asia-Pacific Group |
INTRODUCTION: Data on HIV treatment outcomes in people who inject drugs (PWID) in the Asia-Pacific are sparse despite the high burden of drug use. We assessed immunological and virological responses, AIDS-defining events and mortality among PWID receiving antiretroviral therapy (ART). METHODS: We investigated HIV treatment outcomes among people who acquired HIV via injecting drug use in the TREAT Asia HIV Observational Database (TAHOD) between January 2003 and March 2019. Trends in CD4 count and viral suppression (VS, HIV viral load <1000 copies/mL) were assessed. Factors associated with mean CD4 changes were analysed using repeated measures linear regression, and combined AIDS event and mortality were analysed using survival analysis. RESULTS: Of 622 PWID from 12 countries in the Asia-Pacific, 93% were male and the median age at ART initiation was 31 years (IQR, 28 to 34). The median pre-ART CD4 count was 71 cells/µL. CD4 counts increased over time, with a mean difference of 401 (95% CI, 372 to 457) cells/µL at year-10 (n = 78). Higher follow-up HIV viral load and pre-ART CD4 counts were associated with smaller increases in CD4 counts. Among 361 PWID with ≥1 viral load after six months on ART, proportions with VS were 82%, 88% and 93% at 2-, 5- and 10-years following ART initiation. There were 52 new AIDS-defining events and 50 deaths during 3347 person-years of follow-up (PYS) (incidence 3.05/100 PYS, 95% CI, 2.51 to 3.70). Previous AIDS or TB diagnosis, lower current CD4 count and adherence <95% were associated with combined new AIDS-defining event and death. CONCLUSIONS: Despite improved outcomes over time, our findings highlight the need for rapid ART initiation and adherence support among PWID within Asian settings. © 2021 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society. |
Asia-Pacific; CD4 recovery; HIV/AIDS; people who inject drugs; treatment outcomes; tuberculosis; viral suppression |
nonnucleoside reverse transcriptase inhibitor; proteinase inhibitor; anti human immunodeficiency virus agent; drug; acquired immune deficiency syndrome; adult; all cause mortality; antiretroviral therapy; Article; Asia; CD4 lymphocyte count; cohort analysis; coinfection; female; follow up; hepatitis B; hepatitis C; human; Human immunodeficiency virus; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; incidence; injection drug user; longitudinal study; major clinical study; male; survival analysis; treatment outcome; tuberculosis; virus load; Human immunodeficiency virus infection; treatment outcome; Anti-HIV Agents; Asia; CD4 Lymphocyte Count; Cohort Studies; HIV Infections; Humans; Longitudinal Studies; Male; Pharmaceutical Preparations; Treatment Outc |
John Wiley and Sons Inc |
17582652 |
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34021711 |
Article |
Q1 |
2724 |
762 |
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401 |
Safari D., Gultom S.M., Tafroji W., Azzahidah A., Soesanti F., Khoeri M.M., Prayitno A., Pimenta F.C., da Gloria Carvalho M., Uiterwaal C.S.P.M., Putri N.D. |
23493586700;57223995277;57118271600;57223997121;37068080600;55994827400;57193342301;6603696480;55189494500;7006033434;57200573842; |
Prevalence, serotype and antibiotic susceptibility of Group B Streptococcus isolated from pregnant women in Jakarta, Indonesia |
2021 |
PLoS ONE |
16 |
5 May |
e0252328 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106668508&doi=10.1371%2fjournal.pone.0252328&partnerID=40&md5=d5ae48dcce9738619d131a8193789686 |
Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Faculty of Medicine, Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Aix-Marseille University, Marseille, France; Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Julius Center for Health Sciences and Primary Care, Julius Global Health, University Medical Center, Utrecht, Netherlands |
Safari, D., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Gultom, S.M., Faculty of Medicine, Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Tafroji, W., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Azzahidah, A., Aix-Marseille University, Marseille, France; Soesanti, F., Faculty of Medicine, Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Khoeri, M.M., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Prayitno, A., Faculty of Medicine, Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pimenta, F.C., Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; da Gloria Carvalho, M., Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Uiterwaal, C.S.P.M., Julius Center for Health Sciences and Primary Care, Julius Global Health, University Medical Center, Utrecht, Netherlands; Putri, N.D., Faculty of Medicine, Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Group B Streptococcus (GBS) is a bacterial pathogen which is a leading cause of neonatal infection. Currently, there are limited GBS data available from the Indonesian population. In this study, GBS colonization, serotype distribution and antimicrobial susceptibility profile of isolates were investigated among pregnant women in Jakarta, Indonesia. Demographics data, clinical characteristics and vaginal swabs were collected from 177 pregnant women (mean aged: 28.7 years old) at 29–40 weeks of gestation. Bacterial culture identification tests and latex agglutination were performed for GBS. Serotyping was done by conventional multiplex PCR and antibiotic susceptibility testing by broth microdilution. GBS colonization was found in 53 (30%) pregnant women. Serotype II was the most common serotype (30%) followed by serotype III (23%), Ia and IV (13% each), VI (8%), Ib and V (6% each), and one non-typeable strain. All isolates were susceptible to vancomycin, penicillin, ampicillin, cefotaxime, daptomycin and linezolid. The majority of GBS were resistant to tetracycline (89%) followed by clindamycin (21%), erythromycin (19%), and levofloxacin (6%). The serotype III was more resistant to erythromycin, clindamycin, and levofloxacin and these isolates were more likely to be multidrug resistant (6 out of 10) compared to other serotypes. This report provides demographics of GBS colonization and isolate characterization in pregnant women in Indonesia. The results may facilitate preventive strategies to reduce neonatal GBS infection and improve its treatment. Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. |
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ampicillin; cefotaxime; cefoxitin; ceftizoxime; ciprofloxacin; clindamycin; daptomycin; erythromycin; levofloxacin; linezolid; penicillin derivative; tetracycline; vancomycin; adolescent; adult; antibiotic resistance; antibiotic sensitivity; Article; bacterial colonization; bacterium culture; bacterium identification; bacterium isolate; broth dilution; controlled study; female; gestation period; group B streptococcal infection; human; Indonesia; latex agglutination test; major clinical study; multidrug resistance; multiplex polymerase chain reaction; nonhuman; pregnancy; prevalence; serotype; Streptococcus agalactiae; vagina smear; antibiotic resistance; isolation and purification; pregnancy; pregnancy complication; Streptococcus agalactiae; Streptococcus infection; young adult; Adolescent |
Public Library of Science |
19326203 |
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34043711 |
Article |
Q1 |
990 |
4434 |
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