No records
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600 |
Kusuma F., Matondang S.B., Nuranna L., Purwoto G., Khonsa O., Hyaswicaksono P. |
57192911548;57192085914;55301184300;14720170400;57268401500;57221907604; |
Postradiotherapy outcome on cervical cancer stage IIIB patients with and without paraaortic lymph nodes enlargement [Hasil Pascaradioterapi pada Pasien Kanker Serviks Stadium IIIB dengan dan tanpa Pembesaran Nodus Paraaorta] |
2021 |
Indonesian Journal of Obstetrics and Gynecology |
9 |
1 |
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55 |
58 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115385362&doi=10.32771%2finajog.v9i1.1438&partnerID=40&md5=4fe5c698192ed33c7d6916029327fcbf |
Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Kusuma, F., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Matondang, S.B., Department of Radiology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Nuranna, L., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Purwoto, G., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Khonsa, O., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hyaswicaksono, P., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Objective: To determine whether there are differences in clinical response after radiotherapy and 1 year survival in patients with advanced cervical cancer with and without enlargement of PALN. Methods: An observational analytic study using a retrospective cohort method was done using consecutive sampling. The subjects of this study were all women with a primary diagnosis of stages IIB to IVB cervical cancer who came to the gynecological oncology clinic of Dr. Cipto Mangunkusumo National General Hospital and underwent MRI examination before undergoing treatment in January 2016 to May 2017. Results: Among 76 subjects studied, there were 4 (5.1%) subjects who had enlarged PALN. There were no significant differences between the enlargement status of PALN and age (p = 0.829), age of first sexual intercourse (p = 0.33), parity (p = 0.642), mass diameter (p = 0.777). Patients with PALN enlargement have 2.13 times risk of having negative radiotherapy outcome (p = 0.02, OR 2.13, CI95% 1.12 - 4.07). There was no difference in 1-year survival between patients with and without enlargement of PALN (median 201 vs. 293, p = 0.072). Conclusions: Patients with PALN enlargement have increased risk of having negative radiotherapy outcome (p < 0.05). There were no differences in 1 year survival between patients with advanced cervical cancer with enlargement PALN. © Indonesian Journal of Obstetrics and Gynecology 2021. |
Cervical cancer; Lymph node enlargement; Paraaortic; Radiotherapy |
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Indonesian Society of Obstetrics and Gynecology |
23386401 |
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Article |
#N/A |
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618 |
Djusad S., Meutia A.P., Suastika A., Hidayah G.N., Surya I.U., Priangga M., Fadhly R., Harzif A.K. |
57192276788;57203368133;57226722016;57222671850;57226288663;56320839200;57226710149;57191493435; |
Maternal death caused by severe-critical covid-19 in jakarta: Case series |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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103 |
108 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112449077&doi=10.3889%2foamjms.2021.6250&partnerID=40&md5=e9b76ca77220d8ad24d7f5514bcc5d0d |
Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia |
Djusad, S., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Meutia, A.P., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Suastika, A., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Hidayah, G.N., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Surya, I.U., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Priangga, M., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Fadhly, R., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Harzif, A.K., Department of Obstetric and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia |
BACKGROUND: As of January 2021, Indonesia had the 21st highest number of total COVID-19 cases and the 17th highest total deaths among all countries. COVID-19 infection in pregnant women seems to negatively affect both maternal and neonatal outcomes. CASE REPORT: We describe four cases of pregnant women confirmed with severe and critical COVID-19 that resulted in maternal death from November until December 2020. The first case was complicated with thrombocytopenia, her condition quickly deteriorated post-delivery. Pulmonary embolism was suspected as the cause of death. Second and third cases were complicated with preeclampsia, obesity, and advanced maternal age. Second case came in sepsis condition. Her SARS CoV-2 RTPCR swab test came out after her death. Third patient did not have COVID-19 symptoms at admission. She starts having symptoms on second day and was confirmed positive a day after. She falls in septic shock. Fourth patient has history of fever, cough, and dyspnea. She was confirmed positive on first day and her condition worsened, diagnosed with bacterial co-infection sepsis on day eight. All patients underwent cesarean section. CONCLUSION: Limited information and studies for COVID-19 management in pregnant women are challenging for obstetricians. Management should be individualized weighing the benefit and risks in presence of comorbidities or accompanying disease. © Suskhan Djusad, Alfa Putri Meutia, Arresta Suastika, Gita Nurul Hidayah, Ilham Utama Surya, Muhammad Priangga, Raden Fadhly, Achmad Kemal Harzif. |
Case Series; COVID-19; Indonesia; Maternal Death |
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Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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625 |
Lukito W. |
6701622348; |
Current Evidence in Water and Hydration Science |
2021 |
Annals of nutrition & metabolism |
77 |
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1 |
6 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125594947&doi=10.1159%2f000521769&partnerID=40&md5=dc03696320911a4943e24730854d46e4 |
Postgraduate Program in Physician Specialist-I in Clinical Nutrition/Department of Nutrition, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Lukito, W., Postgraduate Program in Physician Specialist-I in Clinical Nutrition/Department of Nutrition, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
[No abstract available] |
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NLM (Medline) |
14219697 |
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35226915 |
Editorial |
#N/A |
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626 |
Rachman A., Shatri H., Salamat R. |
15056701600;28767986500;57475263300; |
Correlation Between Higher Cumulative Dose of Cisplatin for Concurrent Chemoradiation and Acute Kidney Disease Incidence Among Nasopharyngeal Carcinoma Patients: A Comparative Study |
2021 |
International Journal of General Medicine |
14 |
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10527 |
10539 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125417489&doi=10.2147%2fIJGM.S343644&partnerID=40&md5=5d12476bf92d703d5d6a77517d01d345 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Psychosomatic and Palliative Care, Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Rachman, A., Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Shatri, H., Division of Psychosomatic and Palliative Care, Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Salamat, R., Department of Internal Medicine, Faculty of Medicine, University of Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Introduction: Nasopharyngeal carcinoma (NPC) is the most malignant cancer in the head and neck area. According to the stage, the management of NPC includes radiation, chemotherapy, or a combination of both. The standard agent for radiosensitizing chemotherapy is cisplatin. Among the several effects of cisplatin administration, nephrotoxicity raises the most concern, especially in high doses. Acute kidney disease (AKD) is a condition in which an acute kidney injury occurs at >7 days but <90 days. This study aimed to assess whether there is a significant difference in the incidence of AKD between NPC patients who received a cumulative dose of cisplatin up to (≤) 200 mg/m2 and patients who received more than (>) 200 mg/m2. Methods: This is a cohort retrospective study conducted in the radiotherapy unit of Cipto Mangunkusumo General Hospital. Medical records of 540 patients from January 2014 to December 2018 were collected and sorted. After sorting, 120 of the records were analyzed. Results: The analysis showed that 38.4% of patients who received >200 mg/m2 cumulative dose of cisplatin experienced AKD, whereas 38.3% of the patients who received ≤200 mg/m2 cumulative dose of cisplatin experienced AKD. Conclusion: This study found that in patients with locally advanced NPC who received cisplatin chemoradiation, there was no significant difference in the incidence of AKD, recovery of renal function, or progression of chronic kidney disease between patients receiving a cumulative dose of cisplatin ≤200 mg/m2 and those receiving >200 mg/m2 . © 2021 Rachman et al. |
Acute kidney disease; Chemoradiation; Cisplatin; Nasopharyngeal cancer |
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Dove Medical Press Ltd |
11787074 |
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Article |
Q2 |
722 |
6874 |
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629 |
Kartika R.W., Alwi I., Reksodiputro M.H., Yunir E., Waspadji S., Immanuel S., Silalahi T., Sungkar S., Rachmat J., Bardosono S., Suyatna F.D. |
57223447932;15055173800;35090488800;36520254800;8678136400;57272979000;56275255400;57016857300;6507225348;21933841000;56039633100; |
Combination of Hyaluronic Acid with Advance-Platelet Rich Fibrin to Reduce Chronic Inflammation: a study in IL-6 and Granulation Index |
2021 |
Jordan Journal of Biological Sciences |
14 |
5 |
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983 |
989 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123993135&doi=10.54319%2fJJBS%2f140516&partnerID=40&md5=b5a893eb952c904c665bb27f1cef51cb |
Department of Surgery, Faculty of Medical and Health Science, Krida Wacana Christian University, Jakarta, Indonesia; Doctoral Program in Medical, Science Faculty of Medicine Universitas, Indonesia; Department of Internal Medicine, Faculty of Medicine Universitas Indonesia — Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Department of Clinical Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Kartika, R.W., Department of Surgery, Faculty of Medical and Health Science, Krida Wacana Christian University, Jakarta, Indonesia, Doctoral Program in Medical, Science Faculty of Medicine Universitas, Indonesia; Alwi, I., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia — Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Reksodiputro, M.H., Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia — Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Waspadji, S., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia — Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Silalahi, T., Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Sungkar, S., Department of Clinical Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rachmat, J., Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Suyatna, F.D., Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Type-2 Diabetes mellitus patients have risk of diabetic foot ulcers (DFUs) ranging from 15% to 25% with morbidity of 5% in the first 12 months, and the mortality rate at 5 years is around 42%. AIM: This research was conducted to study the novelty of a combining Hyaluronic Acid (HA) with Advanced Platelet Rich Fibrin (A-PRF) to reduce inflammation in DFUs healing through raising granulation index. METHODS: The study used a randomized control trial design, done from July 2019-March 2020 at Gatot Soebroto Army Hospital and Koja District Hospital, Jakarta. Subjects were DFU wound area < 40 cm2. At the start of the study all subjects received the same treatment, debridement and standard wound care. Twenty subjects were recruited according to the rule of thumb and were randomly divided into two groups namely topical A-PRF + HA (n = 10) and NaCl 0.9% (control) groups (n = 10). A part of the sample was processed into lysate and stored in -80oC. The rest is applied as a topical therapy in DFU base on intervention (A-PRF+HA or NaCl as a control). We analyzed the inflammation use swab sampling in DFU and analyze use ELISA on day- 3 and day-7. We also measured the wound area by a digital photograph and analyzed using ImageJ at the same time. RESULT: From this research, it was obtained 20 DFU subjects with Wagner 2 classification. We also performed analysis of IL-6 from swab topical DFU. A-PRF+HA group was significantly lower than NaCl (control) from swab DFU on day -3 (p = 0,,049) and day-7 (p = 0.041). In A-PRF+HA group affected on increase epithelialization process/ decrease wound area on day-3 (p = 0.016), day-7 (p = 0.048), and day-14 (p= 0.03 CONSLUSION: With the homogeneous gel formation of A-PRF + HA, it will accelerate the formation of granulation tissue compared to conventional NaCl therapy through reduce inflammation by decrease IL-6 levels. In addition, the combination A-PRF + HA has the effect of accelerating the formation of epithelialization shown by decreasing wound area in intervention group. © 2021 Jordan Journal of Biological Sciences. All Rights Reserved. |
Diabetic Foot Ulcer- Advanced Platetelet Rich Fibrin- Hyaluronic Acid-Granulation |
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Hashemite University |
19956673 |
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Article |
Q3 |
216 |
18398 |
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630 |
Indrasari M., Kusdhany L.S., Maharani D.A., Ismail R.I. |
57193349086;55301180900;32867911000;55996895500; |
Development of the Indonesian version of the Oral Health Impact Profile in Edentulous Prosthodontic Patients |
2021 |
Journal of International Dental and Medical Research |
14 |
4 |
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1531 |
1536 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123868913&partnerID=40&md5=29207b68d1256bd93f9c88f61071a0dd |
Prosthodontics Department of, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Preventive and Public Health Dentistry Department, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Psychiatrics Department, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Indrasari, M., Prosthodontics Department of, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Kusdhany, L.S., Prosthodontics Department of, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Maharani, D.A., Preventive and Public Health Dentistry Department, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Ismail, R.I., Psychiatrics Department, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Oral Health Impact Profile in Edentulous (OHIP-EDENT) is an instrument that measures several aspects of oral health-related quality of life as it relates to edentulous patients. Numerous studies have shown that edentulous has an impact on an individual's quality of life. This instrument aids in detecting the impact of oral health on the quality of life of patients who wear prostheses. The purpose of this study was to develop the OHIP-EDENT in Indonesian version for edentulous patients. The questionnaire was translated into Indonesian, back-translated, pre-tested, and crossculturally adapted. The qualitative interviews were carried out of 12 subjects, 46-77 years old, with diverse levels of formal education. All subjects were undergoing complete or single complete denture treatments at Dental Hospital Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia. Since an expert committee agreed upon the original version, the questionnaire was translated, back-translated, and the outcomes of the qualitative interviews were used to finalize the revised instrument. After the pretesting, the adapted Indonesian OHIP-EDENT can be used as an instrument that is easy to use by edentulous patients undergoing complete or single denture treatments. Further analyses of the questionnaire's psychometric properties are needed to confirm its validity and reliability in target settings. © 2021,Journal of International Dental and Medical Research.All Rights Reserved |
Complete denture; Cross-cultural adaptation; Edentulous; Oral health; Quality oflife |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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631 |
Siahaan P.E.A., Kusumawardhani A.A.A.A., Ismail R.I., Malik K. |
57435237600;14633768700;55996895500;57204114533; |
Effectiveness of the "Emotion Recognition" Music Therapy Module in Schizophrenia Patients: A Quasi Experimental Study |
2021 |
Journal of International Dental and Medical Research |
14 |
4 |
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1722 |
1726 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123861310&partnerID=40&md5=d39caa1cc0263ce0e3e32f24151e3bb2 |
Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia |
Siahaan, P.E.A., Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia; Kusumawardhani, A.A.A.A., Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia; Ismail, R.I., Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia; Malik, K., Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia |
One of the deficit domains of social cognition in schizophrenia patients is emotion recognition. Negative emotion recognition deficits, such as emotional deficits of fear, anger, and sadness already exist in the first episode of schizophrenia. Music as therapy is known to be beneficial for emotional improvement, as well as the emotional experience of patients with schizophrenia. This study was aimed to assess the validity and effectiveness of a music therapy module “emotion recognition” in improving recognition of basic emotions in patients with schizophrenia. This quasi experimental study was conducted at the adult outpatient clinic at Cipto Mangunkusumo Hospital. The research was conducted in 2 steps. The first step to assess the validity of the module by calculate the I-CVI, S-CVI, and CVR of validity test and the second step to implement the music therapy module to the patient. This study assessed 15 subjects of schizophrenic remission patients who attended music therapy for 10 sessions conducted from March 2020 to July 2020. Subjects were assessed pre and post music therapy test results to see the effectivity of the module as seen by improvements in recognition of 5 basic emotions (happy, sad, anger, fear, tender) using the Mcnemar statistical test. The results of the validity test of the module showed the I-CVI of 0.98, S-CVI of 0.95, and CVR of 0.97. There was a significant improvement in the emotional deficits of fear and anger, with an increase in the pre and post music therapy test scores with a p-value 0.016 in the anger emotion and 0.008 in fear emotion, but not significant in the happy, sad, and tender emotions (p-value> 0.05). The emotion recognition music therapy module has good content validity, and effectiveness in emotion recognition of some of the basic emotions of remission schizophrenia patients, especially the emotion recognition of fear and anger. © 2021, Journal of International Dental and Medical Research. All Rights Reserved. |
Effectivity; Emotion recognition; Music therapy; Schizophrenia |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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632 |
Arozal W., Barinda A.J., Monayo E.R., Aulia R. |
32067462200;57196373933;56955565900;56955797500; |
Mangiferin Attenuates Doxorubicin-Induced Nephrotoxicity in Rats Through Reduction of Oxidative Stress |
2021 |
Journal of International Dental and Medical Research |
14 |
4 |
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1667 |
1674 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123841744&partnerID=40&md5=1da2ad818beb007235cddc77a1b487fe |
Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Magister Program Biomedical Science, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia |
Arozal, W., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Barinda, A.J., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Monayo, E.R., Magister Program Biomedical Science, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Aulia, R., Magister Program Biomedical Science, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia |
Doxorubicin (DOX) has been widely used in the clinical setting for malignancy treatment.However, it also induces toxicity in a vital organ such as the kidney. Several studies suggest theformation of an iron anthracycline complex which produces free radicals plays an important role innephrotoxicity.Mangiferin (MGF), a xanthone derivate, exhibits as an iron chelator and antioxidant activitythrough a free radical scavenger activity. We analyzed the effect of MGF to prevent DOX inducednephrotoxicity. Male Sprague-Dawley rats were administered MGF orally every day for five weeks,with 50 and 100 mg/kg BW together with DOX. Renal failure and dyslipidemia were detected in theDOX groups in association with increased malondialdehyde (MDA) levels in plasma and kidney anddecreased superoxide dismutase (SOD) and glutathione (GSH) levels in kidney. Of note, cotreatmentwith MGF improved renal dysfunction caused by doxorubicin as shown by theamelioration plasma albumin, urea and creatinine levels, and proteinuria. MGF also diminishedover-production of MDA levels, thus enhanced antioxidant activity such as SOD and GSH in thekidney.Our study opens the perspective to clinical studies for consideration of MGF as a potentialchemoprotectant nutraceutical in the combination chemotherapy with DOX to limit its nephrotoxicity © 2021, Journal of International Dental and Medical Research. All Rights Reserved. |
Doxorubicin; Kidney; Mangiferin; Toxicity |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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633 |
Nadia Y.F., Syahrani R.A., Arumsari S., Sadikin M., Wanandi S.I. |
57428347800;57204103147;57193202336;36981411100;36099320700; |
Effect of Cell Culture Medium on the Proliferation and Stemness of CD24-/CD44+ Human Breast Cancer Stem Cells |
2021 |
Indonesian Biomedical Journal |
13 |
4 |
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355 |
363 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123550895&doi=10.18585%2fINABJ.V13I4.1674&partnerID=40&md5=f0c363bff3a069d364bc71970a109469 |
Master’s Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Molecular Biology and Proteomics Core Facilities, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia |
Nadia, Y.F., Master’s Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Syahrani, R.A., Molecular Biology and Proteomics Core Facilities, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Arumsari, S., Molecular Biology and Proteomics Core Facilities, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Sadikin, M., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Wanandi, S.I., Molecular Biology and Proteomics Core Facilities, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia, Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia, Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia |
BACKGROUND: Cancer stem cells (CSCs) is defined as tumor initiating cells within tumor that maintain stemness properties and tumorigenicity. Extracellular pH of CSCs in in vitro condition is important for supporting cell proliferation which may also regulate the expression of stemness markers such as OCT4. This work aimed to examine the effect of cell culture media on the proliferation and stemness of human breast cancer stem cells (BCSCs). RESULTS: Our results showed a higher viable cell number and proliferation of BCSCs in DMEM/F-12 HEPES (-) compared to HEPES (+) medium until 4 day incubation. OCT4 mRNA and protein level, as well as MFU of BCSCs were significantly higher in HEPES (-) compared to HEPES (+) medium on day 2. CONCLUSION: DMEM/F-12 medium without HEPES facilitates CD24-/CD44+ BCSCs to have higher proliferation and stemness on day 2 incubation compared to those with HEPES. © 2021. All Rights Reserved. |
breast cancer; cancer stem cell; OCT4; proliferation; stemness |
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Prodia Education and Research Institute |
20853297 |
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Article |
Q4 |
160 |
22228 |
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634 |
Fachrucha F., Andarini S., Elhidsi M., Irawan R.Y., Beginta R., Sutoyo D.K. |
57224454767;8716259500;57203157152;57224450720;57428288200;6506079672; |
Pulmonary alveolar proteinosis with secondary Aspergillus infection: A case report |
2021 |
Journal of Health Sciences |
11 |
3 |
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191 |
195 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123527299&doi=10.17532%2fJHSCI.2021.1366&partnerID=40&md5=7d23bb20bec93b3f95d06cf257dca574 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Department of Anatomic Pathology, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Fachrucha, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Andarini, S., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Elhidsi, M., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Irawan, R.Y., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Beginta, R., Department of Anatomic Pathology, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Sutoyo, D.K., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Pulmonary alveolar proteinosis (PAP) is a rare disease with mostly due to autoimmune toward granulocyte-macropahge colony-stimulating factor. In some conditions, PAP followed with secondary infection. A 34-year-old woman came with progressive shortness of breath, chronic dry cough, and mild fever. The chest High-Resolution Computed Tomography showed ground-glass opacity with septal reticulation or known as the crazy-paving pattern, and a cavity on the upper lobe of the left lung. The patient underwent bronchoscopy for diagnostic and therapeutic measures and found milky appearance bronchoalveolar lavage fluid (BALF). The serum galactomannan came out positive. Fungal infection detected from the BALF culture, Aspergillus fumigatus, hence fulfilling the diagnosis of PAP with probable invasive pulmonary aspergillosis. The patient showed clinical improvement after undergoing whole lung lavage and given anti-fungal medications © 2022 Fachrucha, et al.; licensee University of Sarajevo - Faculty of Health Studies |
Fungal infection; Milky appearance bronchoalveolar lavage fluid; Pulmonary alveolar proteinosis; Whole lung lavage |
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University of Sarajevo - Faculty of Health Studies |
22327576 |
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Q4 |
112 |
28273 |
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