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630 |
Indrasari M., Kusdhany L.S., Maharani D.A., Ismail R.I. |
57193349086;55301180900;32867911000;55996895500; |
Development of the Indonesian version of the Oral Health Impact Profile in Edentulous Prosthodontic Patients |
2021 |
Journal of International Dental and Medical Research |
14 |
4 |
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1531 |
1536 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123868913&partnerID=40&md5=29207b68d1256bd93f9c88f61071a0dd |
Prosthodontics Department of, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Preventive and Public Health Dentistry Department, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Psychiatrics Department, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Indrasari, M., Prosthodontics Department of, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Kusdhany, L.S., Prosthodontics Department of, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Maharani, D.A., Preventive and Public Health Dentistry Department, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Ismail, R.I., Psychiatrics Department, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Oral Health Impact Profile in Edentulous (OHIP-EDENT) is an instrument that measures several aspects of oral health-related quality of life as it relates to edentulous patients. Numerous studies have shown that edentulous has an impact on an individual's quality of life. This instrument aids in detecting the impact of oral health on the quality of life of patients who wear prostheses. The purpose of this study was to develop the OHIP-EDENT in Indonesian version for edentulous patients. The questionnaire was translated into Indonesian, back-translated, pre-tested, and crossculturally adapted. The qualitative interviews were carried out of 12 subjects, 46-77 years old, with diverse levels of formal education. All subjects were undergoing complete or single complete denture treatments at Dental Hospital Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia. Since an expert committee agreed upon the original version, the questionnaire was translated, back-translated, and the outcomes of the qualitative interviews were used to finalize the revised instrument. After the pretesting, the adapted Indonesian OHIP-EDENT can be used as an instrument that is easy to use by edentulous patients undergoing complete or single denture treatments. Further analyses of the questionnaire's psychometric properties are needed to confirm its validity and reliability in target settings. © 2021,Journal of International Dental and Medical Research.All Rights Reserved |
Complete denture; Cross-cultural adaptation; Edentulous; Oral health; Quality oflife |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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631 |
Siahaan P.E.A., Kusumawardhani A.A.A.A., Ismail R.I., Malik K. |
57435237600;14633768700;55996895500;57204114533; |
Effectiveness of the "Emotion Recognition" Music Therapy Module in Schizophrenia Patients: A Quasi Experimental Study |
2021 |
Journal of International Dental and Medical Research |
14 |
4 |
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1722 |
1726 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123861310&partnerID=40&md5=d39caa1cc0263ce0e3e32f24151e3bb2 |
Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia |
Siahaan, P.E.A., Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia; Kusumawardhani, A.A.A.A., Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia; Ismail, R.I., Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia; Malik, K., Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia |
One of the deficit domains of social cognition in schizophrenia patients is emotion recognition. Negative emotion recognition deficits, such as emotional deficits of fear, anger, and sadness already exist in the first episode of schizophrenia. Music as therapy is known to be beneficial for emotional improvement, as well as the emotional experience of patients with schizophrenia. This study was aimed to assess the validity and effectiveness of a music therapy module “emotion recognition” in improving recognition of basic emotions in patients with schizophrenia. This quasi experimental study was conducted at the adult outpatient clinic at Cipto Mangunkusumo Hospital. The research was conducted in 2 steps. The first step to assess the validity of the module by calculate the I-CVI, S-CVI, and CVR of validity test and the second step to implement the music therapy module to the patient. This study assessed 15 subjects of schizophrenic remission patients who attended music therapy for 10 sessions conducted from March 2020 to July 2020. Subjects were assessed pre and post music therapy test results to see the effectivity of the module as seen by improvements in recognition of 5 basic emotions (happy, sad, anger, fear, tender) using the Mcnemar statistical test. The results of the validity test of the module showed the I-CVI of 0.98, S-CVI of 0.95, and CVR of 0.97. There was a significant improvement in the emotional deficits of fear and anger, with an increase in the pre and post music therapy test scores with a p-value 0.016 in the anger emotion and 0.008 in fear emotion, but not significant in the happy, sad, and tender emotions (p-value> 0.05). The emotion recognition music therapy module has good content validity, and effectiveness in emotion recognition of some of the basic emotions of remission schizophrenia patients, especially the emotion recognition of fear and anger. © 2021, Journal of International Dental and Medical Research. All Rights Reserved. |
Effectivity; Emotion recognition; Music therapy; Schizophrenia |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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632 |
Arozal W., Barinda A.J., Monayo E.R., Aulia R. |
32067462200;57196373933;56955565900;56955797500; |
Mangiferin Attenuates Doxorubicin-Induced Nephrotoxicity in Rats Through Reduction of Oxidative Stress |
2021 |
Journal of International Dental and Medical Research |
14 |
4 |
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1667 |
1674 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123841744&partnerID=40&md5=1da2ad818beb007235cddc77a1b487fe |
Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Magister Program Biomedical Science, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia |
Arozal, W., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Barinda, A.J., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Monayo, E.R., Magister Program Biomedical Science, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Aulia, R., Magister Program Biomedical Science, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia |
Doxorubicin (DOX) has been widely used in the clinical setting for malignancy treatment.However, it also induces toxicity in a vital organ such as the kidney. Several studies suggest theformation of an iron anthracycline complex which produces free radicals plays an important role innephrotoxicity.Mangiferin (MGF), a xanthone derivate, exhibits as an iron chelator and antioxidant activitythrough a free radical scavenger activity. We analyzed the effect of MGF to prevent DOX inducednephrotoxicity. Male Sprague-Dawley rats were administered MGF orally every day for five weeks,with 50 and 100 mg/kg BW together with DOX. Renal failure and dyslipidemia were detected in theDOX groups in association with increased malondialdehyde (MDA) levels in plasma and kidney anddecreased superoxide dismutase (SOD) and glutathione (GSH) levels in kidney. Of note, cotreatmentwith MGF improved renal dysfunction caused by doxorubicin as shown by theamelioration plasma albumin, urea and creatinine levels, and proteinuria. MGF also diminishedover-production of MDA levels, thus enhanced antioxidant activity such as SOD and GSH in thekidney.Our study opens the perspective to clinical studies for consideration of MGF as a potentialchemoprotectant nutraceutical in the combination chemotherapy with DOX to limit its nephrotoxicity © 2021, Journal of International Dental and Medical Research. All Rights Reserved. |
Doxorubicin; Kidney; Mangiferin; Toxicity |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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633 |
Nadia Y.F., Syahrani R.A., Arumsari S., Sadikin M., Wanandi S.I. |
57428347800;57204103147;57193202336;36981411100;36099320700; |
Effect of Cell Culture Medium on the Proliferation and Stemness of CD24-/CD44+ Human Breast Cancer Stem Cells |
2021 |
Indonesian Biomedical Journal |
13 |
4 |
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355 |
363 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123550895&doi=10.18585%2fINABJ.V13I4.1674&partnerID=40&md5=f0c363bff3a069d364bc71970a109469 |
Master’s Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Molecular Biology and Proteomics Core Facilities, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia |
Nadia, Y.F., Master’s Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Syahrani, R.A., Molecular Biology and Proteomics Core Facilities, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Arumsari, S., Molecular Biology and Proteomics Core Facilities, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Sadikin, M., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Wanandi, S.I., Molecular Biology and Proteomics Core Facilities, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia, Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia, Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia |
BACKGROUND: Cancer stem cells (CSCs) is defined as tumor initiating cells within tumor that maintain stemness properties and tumorigenicity. Extracellular pH of CSCs in in vitro condition is important for supporting cell proliferation which may also regulate the expression of stemness markers such as OCT4. This work aimed to examine the effect of cell culture media on the proliferation and stemness of human breast cancer stem cells (BCSCs). RESULTS: Our results showed a higher viable cell number and proliferation of BCSCs in DMEM/F-12 HEPES (-) compared to HEPES (+) medium until 4 day incubation. OCT4 mRNA and protein level, as well as MFU of BCSCs were significantly higher in HEPES (-) compared to HEPES (+) medium on day 2. CONCLUSION: DMEM/F-12 medium without HEPES facilitates CD24-/CD44+ BCSCs to have higher proliferation and stemness on day 2 incubation compared to those with HEPES. © 2021. All Rights Reserved. |
breast cancer; cancer stem cell; OCT4; proliferation; stemness |
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Prodia Education and Research Institute |
20853297 |
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Article |
Q4 |
160 |
22228 |
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634 |
Fachrucha F., Andarini S., Elhidsi M., Irawan R.Y., Beginta R., Sutoyo D.K. |
57224454767;8716259500;57203157152;57224450720;57428288200;6506079672; |
Pulmonary alveolar proteinosis with secondary Aspergillus infection: A case report |
2021 |
Journal of Health Sciences |
11 |
3 |
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191 |
195 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123527299&doi=10.17532%2fJHSCI.2021.1366&partnerID=40&md5=7d23bb20bec93b3f95d06cf257dca574 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Department of Anatomic Pathology, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Fachrucha, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Andarini, S., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Elhidsi, M., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Irawan, R.Y., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Beginta, R., Department of Anatomic Pathology, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Sutoyo, D.K., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Pulmonary alveolar proteinosis (PAP) is a rare disease with mostly due to autoimmune toward granulocyte-macropahge colony-stimulating factor. In some conditions, PAP followed with secondary infection. A 34-year-old woman came with progressive shortness of breath, chronic dry cough, and mild fever. The chest High-Resolution Computed Tomography showed ground-glass opacity with septal reticulation or known as the crazy-paving pattern, and a cavity on the upper lobe of the left lung. The patient underwent bronchoscopy for diagnostic and therapeutic measures and found milky appearance bronchoalveolar lavage fluid (BALF). The serum galactomannan came out positive. Fungal infection detected from the BALF culture, Aspergillus fumigatus, hence fulfilling the diagnosis of PAP with probable invasive pulmonary aspergillosis. The patient showed clinical improvement after undergoing whole lung lavage and given anti-fungal medications © 2022 Fachrucha, et al.; licensee University of Sarajevo - Faculty of Health Studies |
Fungal infection; Milky appearance bronchoalveolar lavage fluid; Pulmonary alveolar proteinosis; Whole lung lavage |
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University of Sarajevo - Faculty of Health Studies |
22327576 |
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Article |
Q4 |
112 |
28273 |
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635 |
Rahayu G.R., Findyartini A., Riskiyana R., Thadeus M.S., Meidianawaty V., Sari S.M., Puspadewi N., Bekti R.S., Hermasari B.K., Sudarso S., Utami A.E., Kusumawati W. |
56357905400;56543777300;57201674808;57226238484;57205473406;57428214600;57215214003;57195687179;57211539313;57195505857;57427895500;57160948400; |
Stakeholders’ Views and Confidence Towards Indonesian Medical Doctor National Competency Examination: A Qualitative Study |
2021 |
Journal of Multidisciplinary Healthcare |
14 |
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3411 |
3420 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123507676&doi=10.2147%2fJMDH.S336965&partnerID=40&md5=95b31f286039f9e750174fa41df7c1f1 |
Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia; Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia; Faculty of Medicine, Universitas Jenderal Achmad Yani, Cimahi, Indonesia; School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia; Faculty of Medicine, Universitas Mulawarman, Samarinda, Indonesia; Ministry of Research, Technology, and Higher Education, Jakarta, Indonesia; Faculty of Medicine and Health Science, Universitas Muhammadiyah Yogyakarta, Yogyakarta, Indonesia |
Rahayu, G.R., Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Findyartini, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Riskiyana, R., Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Thadeus, M.S., Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia; Meidianawaty, V., Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia; Sari, S.M., Faculty of Medicine, Universitas Jenderal Achmad Yani, Cimahi, Indonesia; Puspadewi, N., School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Bekti, R.S., Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Hermasari, B.K., Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia; Sudarso, S., Faculty of Medicine, Universitas Mulawarman, Samarinda, Indonesia; Utami, A.E., Ministry of Research, Technology, and Higher Education, Jakarta, Indonesia; Kusumawati, W., Faculty of Medicine and Health Science, Universitas Muhammadiyah Yogyakarta, Yogyakarta, Indonesia |
Introduction: Indonesia is a huge country consisting of 33 provinces with different characteristics. There are 83 medical schools across Indonesia with different accreditation statuses. The Indonesia Medical Doctor National Competency Examination (IMDNCE) has been established to control the quality of medical school graduates. The implementation of IMDNCE needed to be evaluated to determine its impact. To date, there has not been any research in Indonesia that explores the stakeholders’ perceptions toward IMDNCE. This study aimed to explore how the stakeholders in Indonesia perceived the impact of IMDNCE towards performances of medical school graduates in clinical practice. Methods and Study Participants: A qualitative study with phenomenological approach was conducted to investigate perceptions of stakeholders including representatives from consumer organizations, the National Health Coverage, the Ministry of Health, the Indonesian Medical Association, employers (hospital and health center directors), clinical supervisors as well as patients across Indonesia. Data were obtained through focus group discussions (FGDs) and interviews. The study used thematic analysis methods to obtain the results. Results: A total of 90 study participants participated in the study including 10 representatives of consumer watchdog organizations, the National Health Coverage, the Ministry of Health, the Indonesian Medical Association, 31 employers, 32 professionals, and 17 patients. The study found three general themes which represent the perceptions of the stakeholders towards performances of medical school graduates in clinical practice: IMDNCE as an effort to standardize doctor graduates in Indonesia, the results of IMDNCE as a mean to reflect the quality of medical education in Indonesia, and IMDNCE as an effort to improve health services in Indonesia through the quality of graduates. Conclusion: In general, the stakeholders perceived that the IMDNCE was able to standardize medical school graduates from various medical schools across Indonesia. However, the IMDNCE needs to be further developed to maximize its potential in improving the competences of Indonesian medical students. © 2021 Rahayu et al. |
Medical education; Medical school graduates; National competency examination; Stakeholder view |
adult; article; clinical practice; consumer organization; employer; female; guard dog; health center; human; Indonesia; interview; major clinical study; male; medical education; medical school; medical society; medical student; nonhuman; perception; physician; public health; qualitative research; thematic analysis |
Dove Medical Press Ltd |
11782390 |
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Article |
Q1 |
650 |
7731 |
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636 |
Wardhani S.O., Fajar J.K., Soegiarto G., Wulandari L., Maliga H.A., Ilmawan M., Merysa R., Simamora A.B., Aini Q., Noviantari K., Lestari A.W., Harnila M.Y., Syafi'i I., Djianzonie J.A.C., Siagian N., Nining S., Hanim R.Z., Wahyuni W., Aulia F., Juliansyah J., Mahmud R., Tamara F., Mahendra A.I., Wowor A.C., Baladraf F., Hadinata P.H., Ikkeputri A., Nadya H., Kartini D.A., Husnah M., Nainu F., Harapan H. |
57193196381;56156139600;57193717004;52464692000;57222334227;57217182580;57412905100;57413600800;57413736700;57412771300;57413600900;57413601000;57412905200;57221505199;57343359200;57413601100;57413182200;57436727400;57413458400;57412905300;57413049000;57192950403;57202301766;57413182300;57412771400;57412905400;57412771500;57413601200;57223337784;57194724156;57120069200;55844857500; |
The association between therapeutic plasma exchange and the risk of mortality among patients critically ill with COVID-19: A meta-analysis. |
2021 |
F1000Research |
10 |
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1280 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122857082&doi=10.12688%2ff1000research.74972.1&partnerID=40&md5=538e74eb0948ed728ed9150f0537f262 |
Division of Hematology and Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Faculty of Nursing, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Faculty of Pharmacy, Universitas Indonesia, Jakarta, s10430, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Faculty of Public Health, Universitas Indonesia, Jakarta, 10430, Indonesia; Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar, 90245, Indonesia; Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia |
Wardhani, S.O., Division of Hematology and Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Fajar, J.K., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Soegiarto, G., Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Wulandari, L., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Maliga, H.A., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Ilmawan, M., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Merysa, R., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Simamora, A.B., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Aini, Q., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Noviantari, K., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Lestari, A.W., Faculty of Nursing, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Harnila, M.Y., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Syafi'i, I., Faculty of Pharmacy, Universitas Indonesia, Jakarta, s10430, Indonesia; Djianzonie, J.A.C., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Siagian, N., Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60286, Indonesia; Nining, S., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Hanim, R.Z., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Wahyuni, W., Faculty of Public Health, Universitas Indonesia, Jakarta, 10430, Indonesia; Aulia, F., Faculty of Public Health, Universitas Indonesia, Jakarta, 10430, Indonesia; Juliansyah, J., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Mahmud, R., Faculty of Nursing, Universitas Indonesia, Jakarta, 10430, Indonesia; Tamara, F., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Mahendra, A.I., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Wowor, A.C., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Baladraf, F., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Hadinata, P.H., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Ikkeputri, A., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Nadya, H., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Kartini, D.A., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Husnah, M., Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Nainu, F., Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar, 90245, Indonesia; Harapan, H., Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia |
Background: Cytokine storm has been widely known to contribute to the development of the critical condition in patients with coronavirus disease 2019 (COVID-19), and studies had been conducted to assess the potential aspect of cytokine storm elimination by performing therapeutic plasma exchange (TPE). However, contradictory findings were observed. The objective of this study was to assess the association between TPE and the reduction of mortality of critically ill COVID-19 patients. Methods: A meta-analysis was conducted by collecting data from PubMed, Scopus, and Web of Science. Data on the mortality rate of critically ill COVID-19 patients treated with TPE plus standard of care and that of patients treated with standard of care alone were analyzed using a Z test. Results: We included a total of four papers assessing the association between TPE and the risk of mortality among critically ill COVID-19 patients. Our findings suggested that critically ill COVID-19 patients treated with TPE had lower risk of mortality compared to those without TPE treatment. Conclusion: Our study has identified the potential benefits of TPE in reducing the risk of mortality among critically ill COVID-19 patients. © 2021 Wardhani SO et al. |
COVID-19therapeutic plasma exchangecytokine stormtreatment |
coronavirus disease 2019; critically ill patient; cytokine storm; human; meta analysis; mortality rate; plasma exchange; Review; systematic review; critical illness; cytokine release syndrome; plasma exchange; COVID-19; Critical Illness; Cytokine Release Syndrome; Humans; Plasma Exchange; SARS-CoV-2 |
F1000 Research Ltd |
20461402 |
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35083038 |
Review |
Q1 |
1099 |
3793 |
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637 |
Tjoa K., Kusmardi K., Midoen Y.H. |
57222366705;56966625300;57197805109; |
Effects of Industrial Waste Fish Oil Administration on Interleukin-6 (Il-6) Expression at Mice Colon being Induced by Azoxymethane (AOM) and Dextran Sodium Sulphate (DSS) |
2021 |
Biomedical and Pharmacology Journal |
14 |
4 |
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2227 |
2233 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122824976&doi=10.13005%2fbpj%2f2321&partnerID=40&md5=bc79b4fdfe0aaabc3c89256150a440fb |
Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Departement of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Departement of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Tjoa, K., Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Kusmardi, K., Departement of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia, Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Midoen, Y.H., Departement of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Colorectal cancer (CRC) is the world's third most cancer and the second highest mortality rate. The searching for new anti-inflammation substances with less adverse effects than aspirin for chemoprevention and adjuvant chemotherapy of CRC is running. The most notable one is fish oil containing omega 3. Kusmardi, et al. studied that industrial waste fish oil omega-3 level comes close enough to conventional fish oil industry. Study aims to reducing the level IL-6 on mice colon tissue being induced CRC using AOM/DSS by fish oil administration. Thirty male Swiss Webster mice are grouped into six treatments: Positive control (aspirin), negative control (physiological saline), normal, high dose (fish oil 6mg/kgBW), medium dose (fish oil 3mg/kgBW), dan solvent control (corn oil). Colon tissue was stained using anti IL-6 antibody. Ten photos per slide were taken by microscope (400x), analyzed for the IL-6 expression by ImageJ®, and quantified for H-score. Data was analyzed using SPSS 24.0 (CI 95%) and p-value <0.05 is consider significant. Data are not normally distributed with median of 161.64 (119.4-260.67). Kruskal-Wallis test is significant in addition with Mann-Whitney test shows only high dose group has significant difference to negative control (p=0.008), medium dose (p=0.016) dan and solvent control (p=0.008). No significant difference reported between high dose and positive control group (p=0.69). High dose industrial waste fish oil can lower IL-6 expression in mice colon tissue induced CRC using AOM/DSS. © 2021 Oriental Scientific Publishing Company. |
Colitis Associated Cancer; Colorectal cancer; Interleukin-6; Omega-3 Fish Oil |
acetylsalicylic acid; CD34 antigen; cytochrome P450 2E1; fish oil; interleukin 6; microRNA; nonsteroid antiinflammatory agent; octamer transcription factor 4; probiotic agent; adjuvant chemotherapy; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; azoxymethane-induced colon carcinogenesis; carcinogenesis; cardiovascular disease; cell proliferation; chemoprophylaxis; colon cancer; colon tissue; colorectal cancer; controlled study; dextran sulfate sodium-induced colitis; DNA methylation; drug megadose; fat intake; genomic instability; histone modification; immunohistochemistry; industrial waste; male; mortality rate; mouse; nonhuman; obesity; peritoneum adhesion; protein expression; quantitative analysis; rheumatoid arthritis; ulcerative colitis |
Oriental Scientific Publishing Company |
09746242 |
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Article |
Q4 |
191 |
19920 |
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638 |
Wiyono L., Rocha I.C.N., Cedeño T.D.D., Miranda A.V., Lucero-Prisno Iii D.E. |
57207889054;57406221700;57224097138;57222664687;56051373800; |
Dengue and COVID-19 infections in the ASEAN region: a concurrent outbreak of viral diseases |
2021 |
Epidemiology and health |
43 |
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e2021070 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122549130&doi=10.4178%2fepih.e2021070&partnerID=40&md5=0876d7707a72acb2031f56c5f9268d61 |
Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; School of Medicine, Centro Escolar University, Manila, Philippines; Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom; Faculty of Management and Development Studies, University of the Philippines Open University, Los Baños, Philippines |
Wiyono, L., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Rocha, I.C.N., School of Medicine, Centro Escolar University, Manila, Philippines; Cedeño, T.D.D., School of Medicine, Centro Escolar University, Manila, Philippines; Miranda, A.V., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Lucero-Prisno Iii, D.E., Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom, Faculty of Management and Development Studies, University of the Philippines Open University, Los Baños, Philippines |
Member countries of the Association of Southeast Asian Nations (ASEAN) have faced dengue outbreaks for decades, and the region has one of the highest rates of dengue globally. Outbreaks continue to occur concurrently with the coronavirus disease 2019 (COVID-19) pandemic in the 10 ASEAN countries. Both infectious diseases pose a tremendous burden in these countries related to both infection control and the economy. Increases in the number of dengue cases occurred in part due to disruptions in the pathogen-host-vector relationship caused by changes in human behaviour in response to the COVID-19 pandemic. The spread of dengue was further aggravated by the implementation of lockdowns and social distancing policies. These measures limited the coverage of dengue preventive programs and delayed the medical management of both diseases due to co-infection and misdiagnosis. It is of the utmost importance for the population to remain aware of both diseases, and dengue vector control strategies must be devised to properly address outbreaks using digitalization and remote surveillance. Similarly, critical triage algorithms and further research are also needed to combat co-infection and misdiagnosis. Controlling the spread of COVID-19 though vaccination should also be undertaken to reduce the impact of the pandemic. |
Asia; COVID-19; Dengue; Infection control |
communicable disease control; dengue; epidemic; human; pandemic; Communicable Disease Control; COVID-19; Dengue; Disease Outbreaks; Humans; Pandemics; SARS-CoV-2 |
NLM (Medline) |
20927193 |
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34607402 |
Article |
Q1 |
1109 |
3739 |
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639 |
Rajabto W., Angkasa Y.K., Harahap A.S., Ham M.F., Brahma B. |
36519576100;57404644300;57218511857;57257336600;55675752700; |
Primary breast lymphoma – a case report [Primární lymfom prsu – kazuistika] |
2021 |
Klinicka Onkologie |
34 |
6 |
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477 |
480 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122541181&doi=10.48095%2fccko2021477&partnerID=40&md5=d7901c39e0619899ff18efe6ce8ac36f |
Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomical Pathology, Dr. Cipto Mangunkusumo General Hospital/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgical Oncology, Dharmais National Cancer Hospital, Jakarta, Indonesia |
Rajabto, W., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Angkasa, Y.K., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harahap, A.S., Department of Anatomical Pathology, Dr. Cipto Mangunkusumo General Hospital/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ham, M.F., Department of Anatomical Pathology, Dr. Cipto Mangunkusumo General Hospital/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Brahma, B., Department of Surgical Oncology, Dharmais National Cancer Hospital, Jakarta, Indonesia |
Background: Primary breast lymphoma is a rare disease and accounts for 0.4–0.5% of malignant breast neoplasms and 1.7–2.2% of extra-nodal lymphomas, with diffuse large B-cell lymphoma (DLBCL) as the most common histologic subtype. Case: A 47-year-old female with beta thalassemia presented with a lump of the left breast, redness, pain, and swelling of her left breast. Physical examination showed tender, red, swollen left breast. Laboratory findings show mild anemia and normal level of lactate dehydrogenase 329 U/L (normal range: 240–480 U/L). PET scan showed hypermetabolic mass with irregular margins covering the whole left breast quadrants with the size of 11.25 × 5.17 cm with left pectoralis major, left parasternal, and left axillary hypermetabolic nodules. Histopathology and immunohistochemistry staining showed a non-germinal center B-cell-like subtype of DLBCL CD20+. We administered the R-CHOP regi-men (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednison) every 3 weeks for 6 cycles. The response was complete remission. The patient tolerated the chemotherapy well and achieved long term complete remission. Conclusion: Primary breast lymphoma is a rare disease with the most common subtype is diffuse large B-cell lymphoma. Systemic chemotherapy R-CHOP is the treatment option for primary breast diffuse large B-cell lymphoma. © 2021, Czech Medical Association J.E. Purkyne. All rights reserved. |
Diffuse large B-cell lymphoma; Primary breast lymphoma; R-CHOP chemotherapy |
CD20 antigen; cyclophosphamide plus doxorubicin plus prednisolone plus rituximab plus vincristine; protein bcl 2; protein bcl 6; antineoplastic agent; cyclophosphamide; doxorubicin; prednisone; R-CHOP protocol; rituximab; vincristine; adult; alopecia; anemia; Article; axillary lymph node; axillary mass; beta thalassemia; breast biopsy; breast cancer; breast tenderness; cancer combination chemotherapy; cancer regression; case report; clinical article; color Doppler flowmetry; diffuse large B cell lymphoma; echomammography; female; histopathology; human; human tissue; immunohistochemistry; laboratory test; middle aged; multiple cycle treatment; nausea and vomiting; neutropenia; pectoralis major muscle; peripheral neuropathy; physical examination; positron emission tomography; primary tumor; |
Czech Medical Association J.E. Purkyne |
0862495X |
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34911334 |
Article |
Q4 |
204 |
19085 |
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