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700 |
Rinaldi I., Prasetyawaty F., Fazlines S., Winston K., Samudera Nurrobi Y.A., Leoni J., Restu Tulus Maha I.H., Wicaksono S., Wicaksono A.Y., Aslani A.O., Ikhsani R. |
23475122400;57285017300;57284131900;57224165400;57283687900;57285017400;57285017500;57204717310;57283688000;57283914100;57283688100; |
Diagnosis and Management of Acquired Hemophilia A: Case Reports and a Literature Review |
2021 |
Case Reports in Medicine |
2021 |
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5554664 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116367653&doi=10.1155%2f2021%2f5554664&partnerID=40&md5=dd3f8e177d1b2f8c901c2f67e106f921 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rinaldi, I., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prasetyawaty, F., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fazlines, S., Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Winston, K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Samudera Nurrobi, Y.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Leoni, J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Restu Tulus Maha, I.H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wicaksono, S., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wicaksono, A.Y., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Aslani, A.O., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ikhsani, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background. Acquired hemophilia A (AHA) is a potentially life-threatening autoimmune hemostatic disorder where autoantibodies that disrupt the functions of factor VIII (FVIII) are present in the circulation. The early diagnosis of AHA is difficult since the symptoms of AHA differ from those of congenital hemophilia A. Furthermore, the management of AHA is also more complex due to the presence of autoantibodies against FVIII (FVIII inhibitors). Here, we present three case reports and conduct a literature review of AHA with the aim to increase awareness and knowledge regarding the diagnosis and treatment of AHA. Case Presentations. We present three patients diagnosed with AHA in these case reports. The first patient was a young female, while the second and third patients were middle-aged and elderly males, respectively. All patients presented with a chief complaint of bruises without hemarthrosis and a history of bleeding. Laboratory examinations of the patients revealed isolated prolonged aPTT, normal PT, and the presence of autoantibodies against factor VIII, which are characteristics of AHA. Patients were then treated with corticosteroids to reduce the titer level of autoantibodies and received factor VIII transfusion to stop bleeding. Conclusion. AHA can be suspected in patients presenting with symptoms of bruises without hemarthrosis and without the history of bleeding. Isolated aPTT elevation with normal PT should raise high suspicion of AHA. The presence of FVIII inhibitors can help to confirm the diagnosis of AHA. Treatment consists of factor VIII transfusion and corticosteroid therapy. Bypassing agents are recommended as an alternative to FVIII transfusion. © 2021 Ikhwan Rinaldi et al. |
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autoantibody; blood clotting factor 8; blood clotting factor 8 antibody; blood clotting factor 8 inhibitor; cyclophosphamide; fresh frozen plasma; methylprednisolone; mycophenolate mofetil; prednisone; prothrombin; recombinant blood clotting factor 8; tranexamic acid; acquired hemophilia A; activated partial thromboplastin time; adult; aged; antibody titer; bleeding; blood cell count; case report; chronic kidney failure; clinical article; contusion; corticosteroid therapy; drug dose reduction; erythrocyte concentrate; erythrocyte transfusion; female; follow up; hand swelling; hemarthrosis; hemophilia A; human; laboratory test; male; medical history; middle aged; ovariectomy; ovary cyst; physical examination; prothrombin time; Review; surgical wound; treatment duration; very elderly; young |
Hindawi Limited |
16879627 |
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Review |
Q4 |
200 |
19317 |
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701 |
Lubis A.C., Iqbal M., Munawar D.A., Hartono B., Munawar M. |
57208338816;57194421966;56470745000;46961152700;16747447600; |
A simple percutaneous retrieval technique for an embolized watchman left atrial appendage closure device in the thoracic aorta using a homemade snare: A case report |
2021 |
International Heart Journal |
62 |
5 |
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1153 |
1155 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116311986&doi=10.1536%2fihj.20-790&partnerID=40&md5=3c507ce9f3cde3738a34ea66de607821 |
Binawaluya Cardiac Center, Jakarta, Indonesia; Faculty of Medicine, Universitas Sumatera Utara, Sumatera Utara, Indonesia; Department of Cardiology and Vascular Medicine, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia |
Lubis, A.C., Binawaluya Cardiac Center, Jakarta, Indonesia, Faculty of Medicine, Universitas Sumatera Utara, Sumatera Utara, Indonesia; Iqbal, M., Binawaluya Cardiac Center, Jakarta, Indonesia; Munawar, D.A., Binawaluya Cardiac Center, Jakarta, Indonesia, Department of Cardiology and Vascular Medicine, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia; Hartono, B., Binawaluya Cardiac Center, Jakarta, Indonesia; Munawar, M., Binawaluya Cardiac Center, Jakarta, Indonesia, Department of Cardiology and Vascular Medicine, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia |
A 60-year old male with paroxysmal atrial fibrillation underwent a combined procedure of left atrial appendage occlusion and pulmonary vein isolation. However, an acute intraprocedural 24-mm Watchman device dislodgement occurred, and thus a decision for urgent surgery was made. However, it was noted during the surgery that the device had migrated further to the descending aorta, just distal to the left subclavian artery. Since a right sternotomy access for retrieval was not feasible, a percutaneous approach was justified. A homemade snare was created using a combination of a long sheath, J-wire, and a regular snare, and the device was successfully retrieved without significant difficulty. © 2021, International Heart Journal Association, All rights reserved. |
Atrial fibrillation; Complication; Left atrial appendage occlusion |
anticoagulant agent; adult; anticoagulation; Article; case report; clinical article; descending aorta; device embolization; drug withdrawal; fluoroscopy; general anesthesia; human; left subclavian artery; male; middle aged; occlusion; paroxysmal atrial fibrillation; percutaneous drainage; percutaneous retrieval technique; pulmonary vein; pulmonary vein isolation; sternotomy; surgical technique; thoracic aorta; transesophageal echocardiography; vascular access; adverse device effect; atrial fibrillation; device removal; devices; heart atrium appendage; heart catheterization; heart surgery; multimodality cancer therapy; procedures; septal occluder; subclavian artery; thoracic aorta; treatment outcome; Aorta, Thoracic; Atrial Appendage; Atrial Fibrillation; Cardiac Catheterization; Cardiac Su |
International Heart Journal Association |
13492365 |
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34544965 |
Article |
Q2 |
555 |
9100 |
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702 |
Deviandri R., van der Veen H.C., Lubis A.M.T., Postma M.J., van den Akker-Scheek I. |
57222171014;57265936900;15122639800;7006296502;55936129400; |
Translation, Cross-Cultural Adaptation, Validity, and Reliability of the Indonesian Version of the IKDC Subjective Knee Form |
2021 |
Orthopaedic Journal of Sports Medicine |
9 |
9 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116266022&doi=10.1177%2f23259671211038372&partnerID=40&md5=ce2114ff8fec736ec8dc0057566bccd5 |
Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; Department of Physiology--Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia; Division of Orthopaedics--Sports Injury, Arifin Achmad Hospital, Pekanbaru, Indonesia; Department of Orthopaedics--Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Health Sciences, University of Groningen, University Medical Center Groningen, Netherlands; Department of Economics, Econometrics and Finance, University of Groningen, Faculty of Economics Business, Groningen, Netherlands; Department of Pharmacology and Therapy, Universitas Airlangga, Surabaya, Indonesia; Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, Indonesia |
Deviandri, R., Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, Department of Physiology--Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia, Division of Orthopaedics--Sports Injury, Arifin Achmad Hospital, Pekanbaru, Indonesia; van der Veen, H.C., Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; Lubis, A.M.T., Department of Orthopaedics--Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Postma, M.J., Department of Health Sciences, University of Groningen, University Medical Center Groningen, Netherlands, Department of Economics, Econometrics and Finance, University of Groningen, Faculty of Economics Business, Groningen, Netherlands, Department of Pharmacology and Therapy, Universitas Airlangga, Surabaya, Indonesia, Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, Indonesia; van den Akker-Scheek, I., Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands |
Background: No questionnaire is currently available for use in patients with anterior cruciate ligament (ACL) injuries in an Indonesian population. The most-used questionnaire in clinical research for these patients is the International Knee Documentation Committee (IKDC) Subjective Knee Form, as its psychometric properties are considered to be excellent. Purpose: To translate the IKDC into Indonesian and assess its validity for use in Indonesian-speaking patients with ACL injuries. Study Design: Cohort study (diagnosis); Level of evidence, 2. Methods: After a forward-and-backward translation procedure and cross-cultural adaptation, the validity and reliability of the questionnaire were investigated. The responses of ACL injury patients on 3 questionnaires, the Indonesian-IKDC (I-IKDC), 36-Item Short Form Health Survey, and Kujala Anterior Knee Pain Scale, were compared. Following consensus-based standards for the selection of health measurement instruments guidelines, construct validity, test-retest reliability, internal consistency, floor and ceiling effects, and measurement error were determined. The Bland-Altman method was used to explore absolute agreement. Results: Of 253 ACL injury patients, 106 (42%) responded to the invitation. Construct validity was considered good, as all predefined hypotheses on correlations between the I-IKDC and other scores were confirmed. Reliability proved excellent, with a high test-retest correlation (intraclass correlation coefficient = 0.99). Bland-Altman analyses showed no systematic bias between test and retest. Internal consistency was good (Cronbach α =.90). There were no floor or ceiling effects. Standard error of measurement was 2.1, and the minimal detectable change was 5.8 at the individual level and 0.7 at the group level. Conclusion: The I-IKDC, as developed, appeared to be a good evaluation instrument for Indonesian patients with ACL injuries. © The Author(s) 2021. |
anterior cruciate ligament; IKDC; Indonesian version; reliability; validity |
adult; Article; controlled study; female; human; human experiment; human tissue; major clinical study; male; retrospective study |
SAGE Publications Ltd |
23259671 |
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Article |
Q1 |
1329 |
2772 |
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703 |
Massenburg B.B., Hopper R.A., Crowe C.S., Morrison S.D., Alonso N., Calis M., Donkor P., Kreshanti P., Yuan J. |
55859007400;57277146200;55976347800;45661573100;7004026436;53263345100;15063876600;36192866200;57278294200; |
Global Burden of Orofacial Clefts and the World Surgical Workforce |
2021 |
Plastic and Reconstructive Surgery |
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568E |
580E |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115936193&doi=10.1097%2fPRS.0000000000008334&partnerID=40&md5=b6aab0e1c64506de878c4f09a9d86d70 |
Division of Plastic and Reconstructive Surgery, University of Washington, Seattle, WA, United States; Division of Craniofacial and Plastic Surgery, Seattle Children's Hospital, Division of Plastic Surgery, Department of Surgery, University of São Paulo, São Paulo, Brazil; Department of Plastic, Reconstructive, and Aesthetic Surgery, Hacettepe University, Ankara, Turkey; Department of Surgery, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cleft and Craniofacial Center Dr. Cipto Mangunkusumo Hospital; and School of Medicine, Shanghai Jiao Tong University, Shanghai, China |
Massenburg, B.B., Division of Plastic and Reconstructive Surgery, University of Washington, Seattle, WA, United States; Hopper, R.A., Division of Plastic and Reconstructive Surgery, University of Washington, Seattle, WA, United States; Crowe, C.S., Division of Craniofacial and Plastic Surgery, Seattle Children's Hospital, Division of Plastic Surgery, Department of Surgery, University of São Paulo, São Paulo, Brazil; Morrison, S.D., Department of Plastic, Reconstructive, and Aesthetic Surgery, Hacettepe University, Ankara, Turkey; Alonso, N., Department of Plastic, Reconstructive, and Aesthetic Surgery, Hacettepe University, Ankara, Turkey; Calis, M., Department of Surgery, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Donkor, P., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kreshanti, P., Cleft and Craniofacial Center Dr. Cipto Mangunkusumo Hospital; and School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Yuan, J., Division of Plastic and Reconstructive Surgery, University of Washington, Seattle, WA, United States |
Background: Orofacial clefts are one of the most common congenital anomalies, but this disease burden is unevenly distributed worldwide. The authors hypothesize that this burden falls disproportionately on the countries with the smallest surgical workforce or lowest Socio-Demographic Index, rather than those with the highest prevalence of disease. Methods: The authors estimated the prevalence and disease burden of orofacial clefting from 1990 to 2017 in 195 countries using the Global Burden of Disease methodology. Prevalence and disability-adjusted life-years were compared geographically, temporally, and against the size of the national surgical workforce, Socio-Demographic Index, and income status. Linear and logarithmic regressions were performed. Results: In 2017, the prevalence of orofacial clefting was estimated to be 10.8 million people, representing a disease burden of 652,084 disability-adjusted life-years, with most of this disease burden experienced by low- and middle-income countries (94.1%). From 1990 to 2017, there was a decrease in disease burden (-70.2%) and prevalence (-4.9%). There was negative logarithmic association between surgical workforce size and disease burden, with a surgical workforce of greater than six providers per 100,000 population (3.6 disability-adjusted life-years versus 22.4 disability-adjusted life-years per 100,000 population; p < 0.0001). Conclusions: Burden of orofacial clefting has a strong negative association with the size of the surgical workforce, suggesting that strengthening the surgical workforce will help alleviate this burden. Epidemiologic data on countries and regions with inadequate surgical workforces and high disease burden should guide future research efforts and allocation of resources, and guide the treatment and educational goals of international charitable organizations. © 2021 Lippincott Williams and Wilkins. All rights reserved. |
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cleft lip; cleft palate; global disease burden; global health; health service; human; organization and management; prevalence; reconstructive surgery; Cleft Lip; Cleft Palate; Global Burden of Disease; Global Health; Health Services Needs and Demand; Health Workforce; Humans; Prevalence; Reconstructive Surgical Procedures |
Lippincott Williams and Wilkins |
00321052 |
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34550940 |
Article |
Q1 |
1841 |
1560 |
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704 |
Setiani R.U., Batubara E.A.D., Adiarto S., Siddiq T., Indriani S., Siahaan I.H. |
57277340700;57220786003;8603606800;57206239827;57213831064;57278163100; |
Successful Ovarian Vein Embolization of a Multiparous Woman with Pelvic Congestion Syndrome |
2021 |
International Journal of Angiology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115934784&doi=10.1055%2fs-0041-1731272&partnerID=40&md5=3d3e2b558ea0c0ec2f0afad82a5a9503 |
Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, 11420, Indonesia; Department of Cardiology and Vascular Medicine, Persahabatan Public Hospital, Jakarta, Indonesia |
Setiani, R.U., Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, 11420, Indonesia; Batubara, E.A.D., Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, 11420, Indonesia; Adiarto, S., Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, 11420, Indonesia; Siddiq, T., Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, 11420, Indonesia; Indriani, S., Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, 11420, Indonesia; Siahaan, I.H., Department of Cardiology and Vascular Medicine, Persahabatan Public Hospital, Jakarta, Indonesia |
Pelvic congestion syndrome (PCS) is a clinical syndrome supported by specific findings, such as ovarian vein's dilatation, that cause pelvic vein congestion. Although many theories are explaining the pathophysiologies of this condition, the underlying cause remains unknown. The clinical manifestations of PCS are various including chronic pelvic pain (CPP), voiding disturbances, or ureteral obstruction. Imaging modality, such as ultrasonography, computed tomography (CT scan), magnetic resonance imaging (MRI), and venography, are needed to confirm and exclude the differential diagnosis. Currently, American venous forum guidelines recommended endovascular therapy which is percutaneous embolization as the first option therapy of PCS. Here, we reported a 35-year-old woman with PCS who underwent successful percutaneous embolization therapy. © 2021. International College of Angiology. All rights reserved. |
chronic pelvic pain; multiparous woman; pelvic congestion syndrome; percutaneous embolization; venography |
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Thieme Medical Publishers, Inc. |
10611711 |
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Article |
Q3 |
293 |
15070 |
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705 |
Muharam R., Sumapraja K., Pratama G., Azyati M., Prabowo K.A. |
57191492732;55819683500;57195959221;57274785700;57224859187; |
Impact of ivf on the timing and symptoms of menopause |
2021 |
International Journal of Women's Health |
13 |
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889 |
893 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115838581&doi=10.2147%2fIJWH.S322718&partnerID=40&md5=6d1216144e47b8cdba986eef18fc94e5 |
Department of Obstetrics & Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
Muharam, R., Department of Obstetrics & Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Sumapraja, K., Department of Obstetrics & Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Pratama, G., Department of Obstetrics & Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Azyati, M., Department of Obstetrics & Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Prabowo, K.A., Department of Obstetrics & Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
Background: Age-related loss of female fertility is characterized by a decline in both the quantity and quality of ovarian follicles. Symptoms of ovarian stimulation, which is part of the process of in vitro fertilization (IVF), vary among women. This study was conducted to analyze the differences in menopausal timing and symptoms in women who had undergone IVF compared to those who had natural pregnancies. Methodology: In this cross-sectional study, menopausal women were categorized into two groups: those who had undergone IVF (n = 50) and those who had not (n = 50). Clinical data were obtained from the participants’ medical records, and patient interviews were conducted using the menopause rating scale (MRS) questionnaires. Results: The IVF had no significant impact on psychological or somatic symptoms in either group (p>0.05). However, it affected urogenital symptoms (p<0.05). Additionally, there was a significant difference in the age of onset of menopause between the groups (p<0.05). Conclusion: There is a significant correlation between IVF treatment, urogenital symptoms in menopause, and the age of onset of menopause. © 2021 Muharam et al. This work is published and licensed by Dove Medical Press Limited. |
In vitro fertilization; Infertility; Menopause; Psychological symptoms; Urogenital |
adult; anxiety; arthralgia; Article; bladder dysfunction; clinical article; cross-sectional study; depression; exhaustion; female; hot flush; human; in vitro fertilization; irritability; menopause; menopause rating scale; middle aged; myalgia; onset age; rating scale; risk factor; sexual dysfunction; sleep disorder; vaginal dryness |
Dove Medical Press Ltd |
11791411 |
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Article |
Q1 |
1136 |
3603 |
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706 |
Wardhani B.W.K., Louisa M., Watanabe Y., Setiabudy R., Kato M. |
57194342020;41461551400;56040433300;6602316235;57222489115; |
Tgf-β-induced tmepai promotes epithelial– mesenchymal transition in doxorubicin-treated triple-negative breast cancer cells via smad3 and pi3k/akt pathway alteration |
2021 |
Breast Cancer: Targets and Therapy |
13 |
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529 |
538 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115827526&doi=10.2147%2fBCTT.S325429&partnerID=40&md5=0fe888a00b703b194e1cca6235180684 |
Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology, Faculty of Military Pharmacy, Indonesia Defense University, West Java, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Experimental Pathology, Graduate School of Comprehensive Human Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan |
Wardhani, B.W.K., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Pharmacology, Faculty of Military Pharmacy, Indonesia Defense University, West Java, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Watanabe, Y., Department of Experimental Pathology, Graduate School of Comprehensive Human Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; Setiabudy, R., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kato, M., Department of Experimental Pathology, Graduate School of Comprehensive Human Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan |
Introduction: Epithelial–mesenchymal transition (EMT) and overexpression of drug efflux transporters have been reported to cause doxorubicin resistance. Our previous study indicated that TMEPAI (transmembrane prostate androgen-induced protein) attenuated doxorubicin sensitivity in triple-negative breast cancer cells. However, how TMEPAI contributes to doxorubicin resistance in TNBC remains unclear. Thus, the present study aimed to elucidate the mechanism of TMEPAI in doxorubicin resistance in triple-negative breast cancer cells. Methods: We used BT549, triple-negative cells wild type (WT), and BT549 TMEPAI knock-out. Both cells were treated with TGF-β 2 ng/mL for 24 hours, followed by TGF-β 2 ng/mL and doxorubicin 12.9 nM for another 24 hours. Afterward, the cells were harvested and counted. Cells were further lysed and used for RT-PCR and Western blot analysis. We determined the expression levels of proliferation, apoptosis, EMT markers, and drug efflux transporters. Additionally, we investigated the expressions of PI3K as well as SMAD3 and AKT phosphorylation. Results: TNBC cells were shown to be less sensitive to doxorubicin in the presence of TMEPAI. TMEPAI was shown to alleviate the mRNA expressions of apoptosis markers: Bax, Bcl2, Caspase-3, and Caspase-9. Our results indicated that the presence of TMEPAI greatly amplifies EMT and increases drug efflux transporter expressions after doxorubicin treatment. Furthermore, our findings demonstrated that TMEPAI reduced the action of doxorubicin in inhibiting SMAD3 phosphorylation. TMEPAI was also shown to modify the effect of doxorubicin by reducing PI3K expressions and Akt phosphorylation in triple-negative breast cancer cells. Conclusion: Our findings indicate that TMEPAI promotes EMT and drug efflux transporters at least in part by shifting doxorubicin action from SMAD3 phosphorylation reduction to PI3K/AKT inhibition in triple-negative breast cancer cells. © 2021 Wardhani et al. |
Drug efflux transporters; E-cadherin; PMEPAI; SMAD3; TGF-β; Vimentin |
ABC transporter subfamily B; caspase 3; caspase 9; complementary DNA; doxorubicin; Ki 67 antigen; membrane protein; protein Bax; Smad3 protein; transforming growth factor beta; transmembrane prostate androgen induced protein; unclassified drug; uvomorulin; vimentin; apoptosis; Article; breast cancer cell line; cell proliferation; cell viability; chemoluminescence; controlled study; CRISPR-CAS9 system; down regulation; epithelial mesenchymal transition; gene expression; gene overexpression; human; human cell; mRNA expression level; Pi3K/Akt signaling; protein expression; protein phosphorylation; real time polymerase chain reaction; RNA extraction; signal transduction; upregulation; Western blotting |
Dove Medical Press Ltd |
11791314 |
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Article |
Q2 |
1190 |
3344 |
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707 |
Aulia I., Mustika R., Menaldi S.L. |
57204495153;57220273147;57192918198; |
Impact of Women's Domination in Plastic Surgery Residency Program in Indonesia |
2021 |
Plastic and Reconstructive Surgery - Global Open |
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e3757 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115629156&doi=10.1097%2fGOX.0000000000003757&partnerID=40&md5=de23c6b8c2c9f64536023cb3cf54a1f3 |
Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, RSCM Gedung A, Jalan Diponegoro No. 71, DKI Jakarta, Jakarta Pusat, 10430, Indonesia; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cluster of Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Dermatovenereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Aulia, I., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, RSCM Gedung A, Jalan Diponegoro No. 71, DKI Jakarta, Jakarta Pusat, 10430, Indonesia, Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mustika, R., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cluster of Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Menaldi, S.L., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Dermatovenereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: A shift in gender dominance from man to woman in the medical field has occurred from time to time globally, including in Indonesia's plastic surgery community. This shift may alter the education and clinical settings of plastic surgery. This study aimed to explore the effect of the phenomenon of women's dominance in plastic surgery residency programs in Indonesia. Methods: This qualitative study was conducted using a phenomenological approach on three plastic surgery residency programs in Indonesia. Academic report review, focus group discussions, and in-depth interviews of residents, lecturers, residency program managers, and alumni user groups were selected using the maximum variation sampling method. Data obtained were analyzed and processed thematically. Results: Three themes emerged based on the educational process timeline: pre-education, intra-education, and post-education. Each timeline had several themes that mutually influenced the educational process. In the pre-educational process, residents' personal characters were affected by societies' positive and negative perceptions. The working environment, impact of women's dominance, and cultural dimension affected the intra-educational process. When entering the career life, residents expected an ideal working environment and had particular workplace preferences to achieve their well-being. Conclusions: The impact of women's dominance during the educational program affected residents' daily dynamics. However, this dominance did not affect the quality of education and workloads. © 2021 Lippincott Williams and Wilkins. All rights reserved. |
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Lippincott Williams and Wilkins |
21697574 |
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Article |
Q2 |
759 |
6437 |
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708 |
Fajar Marta K., Moegni F. |
57270493200;55450456100; |
Level of agreement and acceptance of the 20-Minute versus 60-Minute sanitary pad test as a method for measuring the severity of stress urinary incontinence: randomised crossover trial |
2021 |
Journal of Obstetrics and Gynaecology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115614159&doi=10.1080%2f01443615.2021.1951689&partnerID=40&md5=937e03ea21fd672e116e87581915560c |
Department of Obstetrics and Gynecology, Faculty of Medicine Udayana University/Sanglah Hospital, Denpasar, Indonesia; Reconstructive Urogynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Fajar Marta, K., Department of Obstetrics and Gynecology, Faculty of Medicine Udayana University/Sanglah Hospital, Denpasar, Indonesia; Moegni, F., Reconstructive Urogynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
We aimed to measure the level of agreement and acceptance ratio of the 20-minute versus 60-minute sanitary pad test in female patients with stress urinary incontinence (SUI). This is one-sample cross-experimental design. SUI patients at the Urogynecology Outpatient Clinic at Cipto Mangunkusumo Hospital in Jakarta, Indonesia were consecutively enrolled as participants. We first administered the 20-minute test, followed by the 60-minute test, or vice versa, within 1 week. The participants did not know the type of test performed or asked during the interview. Random Number Generator software by stattrek.com was used to determine which test was performed first for each participant. Participants were interviewed using a questionnaire at the end of each test. The 20-minute sanitary pad test exhibited a good level of agreement with the 60-minute sanitary pad test (kappa R = 0.84). Forty-two respondents (84.0%) reported that they were “satisfied” with the 20-minute sanitary pad test and eight respondents (16.0%) reported that they were “very satisfied”. There was a good agreement between the 20-minute and 60-minute sanitary pad test for assessing the severity of SUI. The 20-minute sanitary pad test achieved a relatively higher level of participant satisfaction.Impact statementWhat is already known on this subject? Patients at the Urogynecology Outpatient Clinic at Cipto Mangunkusumo Hospital have a positive acceptance in the 20-minute and 60-minute sanitary pad test for assessing the severity of SUI. What do the results of this study add? From this result, the authors considered that this method can help in assessing the severity of SUI, especially in Indonesia. What are the implications of these findings for clinical practice and/or further research? As these findings, the authors think that they might be useful as a standard of assessed the severity of SUI. This method does not harmful and easy to apply for every patient with SUI. © 2021 Informa UK Limited, trading as Taylor & Francis Group. |
agreement; Pad test; satisfaction; stress urinary incontinence |
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Taylor and Francis Ltd. |
01443615 |
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Article |
Q3 |
390 |
12371 |
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709 |
Ayu Asri Prima Dewi A.A., Antarianto R.D., Pawitan J.A. |
57268721600;57190862806;6508348067; |
Characterization of indonesia decellularized liver cubes scaffold using scanning electron microscopy |
2021 |
Journal of Biomimetics, Biomaterials and Biomedical Engineering |
52 |
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38 |
46 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115446740&doi=10.4028%2fwww.scientific.net%2fJBBBE.52.38&partnerID=40&md5=c7fc1ea62d3680df39cd8c77bf963ba1 |
Master Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia; Department of Histology, Faculty of Medicine, Warmadewa University, Jl. Terompong 24 Tanjung Bungkak, Denpasar, Bali, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia; Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia; Integrated Stem Cell Technology Service Unit, Cipto Mangunkusumo National General Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia |
Ayu Asri Prima Dewi, A.A., Master Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia, Department of Histology, Faculty of Medicine, Warmadewa University, Jl. Terompong 24 Tanjung Bungkak, Denpasar, Bali, Indonesia; Antarianto, R.D., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia, Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia; Pawitan, J.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia, Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia, Integrated Stem Cell Technology Service Unit, Cipto Mangunkusumo National General Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia |
Liver biological scaffold was developed in order to resemble native liver tissue environment. It can be achieved by decellularizing native liver tissue that will remove cells and preserve extracellular matrix (ECM). Furthermore, ECM fibers are arranged in a special pattern, which affect liver cell polarity and topography that are important for cells’ implantation, proliferation and differentiation. Therefore, the aim of this study was to evaluate liver cube scaffold topography that was decellularized with fixed multiple sites syringe injection (Indonesia patent number: S00201907930). Rat liver cubes (n=3) underwent decellularization with Ethylene Glycol Tetraacetic Acid (EGTA) immersion and increased Sodium Dodecyl Sulfate (SDS) concentrations using previous multiple sites syringe injection protocol study. Deoxyribonucleic Acid (DNA) concentrations were measured to confirm less DNA materials remaining in scaffolds. Scanning Electron Microscope (SEM) analysis of scaffolds were conducted for topographic characterization compared to undecellularized liver control. Molecular analysis of DNA concentration showed complete removal of DNA material. SEM analysis gave appearance of intact liver cube scaffold microarchitecture. Liver cubes decellularization using multiple sites syringe injection showed good topographic liver scaffold characterization. © 2021 Trans Tech Publications Ltd, Switzerland. |
Liver biological scaffold; Liver cube tissue; Liver decellularization; Multiple site syringe injection; Scanning electron microscope |
Cytology; DNA; Ethylene; Ethylene glycol; Geometry; Scaffolds (biology); Sodium dodecyl sulfate; Sulfur compounds; Syringes; Tissue; Acid concentrations; Biological scaffolds; Decellularization; Extracellular matrices; Indonesia; Liver biological scaffold; Liver cube tissue; Liver decellularization; Liver tissue; Multiple site syringe injection; Scanning electron microscopy |
Trans Tech Publications Ltd |
22969837 |
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Article |
Q4 |
183 |
20493 |
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